253 research outputs found
Observation of two-wave structure in strongly nonlinear dissipative granular chains
In a strongly nonlinear viscous granular chain under conditions of loading
that exclude stationary waves (e.g., impact by a single grain) we observe a
pulse that consists of two interconnected but distinct parts. One is a leading
narrow "primary pulse" with properties similar to a solitary wave in a "sonic
vacuum." It arises from strong nonlinearity and discreteness in the absence of
dissipation, but now decays due to viscosity. The other is a broad, much more
persistent shock-like "secondary pulse" trailing the primary pulse and caused
by viscous dissipation. The medium behind the primary pulse is transformed from
a "sonic vacuum" to a medium with finite sound speed. When the rapidly decaying
primary pulse dies, the secondary pulse continues to propagate in the "sonic
vacuum," with an oscillatory front if the viscosity is relatively small, until
its eventual (but very slow) disintegration. Beyond a critical viscosity there
is no separation of the two pulses, and the dissipation and nonlinearity
dominate the shock-like attenuating pulse which now exhibits a nonoscillatory
front
Anomalous wave reflection from the interface of two strongly nonlinear granular media
Granular materials exhibit a strongly nonlinear behaviour affecting the
propagation of information in the medium. Dynamically self-organized strongly
nonlinear solitary waves are the main information carriers in granular chains.
Here we report the first experimental observation of the dramatic change of
reflectivity from the interface of two granular media triggered by a noncontact
magnetically induced initial precompression. It may be appropriate to name this
phenomenon the "acoustic diode" effect. Based on numerical simulations, we
explain this effect by the high gradient of particle velocity near the
interface.Comment: 14 pages, 3 figure
Single cell analyses reveal contrasting life strategies of the two main nitrifiers in the ocean
Nitrification, the oxidation of ammonia via nitrite to nitrate, is a key process in marine nitrogen (N) cycling. Although oceanic ammonia and nitrite oxidation are balanced, ammonia-oxidizing archaea (AOA) vastly outnumber the main nitrite oxidizers, the bacterial Nitrospinae. The ecophysiological reasons for this discrepancy in abundance are unclear. Here, we compare substrate utilization and growth of Nitrospinae to AOA in the Gulf of Mexico. Based on our results, more than half of the Nitrospinae cellular N-demand is met by the organic-N compounds urea and cyanate, while AOA mainly assimilate ammonium. Nitrospinae have, under in situ conditions, around four-times higher biomass yield and five-times higher growth rates than AOA, despite their ten-fold lower abundance. Our combined results indicate that differences in mortality between Nitrospinae and AOA, rather than thermodynamics, biomass yield and cell size, determine the abundances of these main marine nitrifiers. Furthermore, there is no need to invoke yet undiscovered, abundant nitrite oxidizers to explain nitrification rates in the ocean
Discovery of a new genus of anaerobic ammonium oxidizing bacteria with a mechanism for oxygen tolerance
In the past 20 years, there has been a major stride in understanding the core mechanism of anaerobic ammonium-oxidizing (anammox) bacteria, but there are still several discussion points on their survival strategies. Here, we discovered a new genus of anammox bacteria in a full-scale wastewater-treating biofilm system, tentatively named “Candidatus Loosdrechtia aerotolerans”. Next to genes of all core anammox metabolisms, it encoded and transcribed genes involved in the dissimilatory nitrate reduction to ammonium (DNRA), which coupled to oxidation of small organic acids, could be used to replenish ammonium and sustain their metabolism. Surprisingly, it uniquely harbored a new ferredoxin-dependent nitrate reductase, which has not yet been found in any other anammox genome and might confer a selective advantage to it in nitrate assimilation. Similar to many other microorganisms, superoxide dismutase and catalase related to oxidative stress resistance were encoded and transcribed by “Ca. Loosdrechtia aerotolerans”. Interestingly, bilirubin oxidase (BOD), likely involved in oxygen resistance of anammox bacteria under fluctuating oxygen concentrations, was identified in “Ca. Loosdrechtia aerotolerans” and four Ca. Brocadia genomes, and its activity was demonstrated using purified heterologously expressed proteins. A following survey of oxygen-active proteins in anammox bacteria revealed the presence of other previously undetected oxygen defense systems. The novel cbb3-type cytochrome c oxidase and bifunctional catalase-peroxidase may confer a selective advantage to Ca. Kuenenia and Ca. Scalindua that face frequent changes in oxygen concentrations. The discovery of this new genus significantly broadens our understanding of the ecophysiology of anammox bacteria. Furthermore, the diverse oxygen tolerance strategies employed by distinct anammox bacteria advance our understanding of their niche adaptability and provide valuable insight for the operation of anammox-based wastewater treatment systems
Wind environment evaluation on major town of Malaysia
This study focus on wind flow or wind environment of residential areas in Peninsular Malaysia, Sabah and Sarawak. Natural wind flow is one of the most effective methods to help achieve the energy saving in large cities especially under the tropical climate like Malaysia. The weather in Malaysia is characterized by four monsoon regimes, namely, the southwest monsoon, northeast monsoon and two shorter periods of inter-monsoon seasons. For this study, the data of wind velocity in twentytwo (22) weather station in Malaysia obtained from Meteorological Department and considered in wind environment evaluations. Then that data of wind velocities will
convert to 1.5
in height at all measuring points were calculated by using the
law. The result compared by Table 2.2 in previous researches (Kubota and Miura et al.,
2002). From the study, it was found out, in Malaysia there are only two type of wind. First type is weak wind means that area are discomfort thermal and the second type is comfort range to strong wind means that area are comfort thermal. The minimum value
of mean wind speed from 2005 to 2009 is O.mis in mean temperature is over 2C at Sitiawan. For the maximum value of mean wind speed is I .7m/s in average value of
mean temperature is 276C
at Mersing. Base on results, it can be concluded that when considering wind flow at a residential area, terrace housing is not a suitable option for towns located on the south of the Peninsular. It was prefer for high-rise building because it was considered this location of towns was weak wind condition. On the other hand, the major towns exclude the south of the Peninsular including Sabah and Sarawak, they was under the comfort thermal. So, terrace housing or high-rise building is suitable
option
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Expansion of Thaumarchaeota habitat range is correlated with horizontal transfer of ATPase operons.
Thaumarchaeota are responsible for a significant fraction of ammonia oxidation in the oceans and in soils that range from alkaline to acidic. However, the adaptive mechanisms underpinning their habitat expansion remain poorly understood. Here we show that expansion into acidic soils and the high pressures of the hadopelagic zone of the oceans is tightly linked to the acquisition of a variant of the energy-yielding ATPases via horizontal transfer. Whereas the ATPase genealogy of neutrophilic Thaumarchaeota is congruent with their organismal genealogy inferred from concatenated conserved proteins, a common clade of V-type ATPases unites phylogenetically distinct clades of acidophilic/acid-tolerant and piezophilic/piezotolerant species. A presumptive function of pumping cytoplasmic protons at low pH is consistent with the experimentally observed increased expression of the V-ATPase in an acid-tolerant thaumarchaeote at low pH. Consistently, heterologous expression of the thaumarchaeotal V-ATPase significantly increased the growth rate of E. coli at low pH. Its adaptive significance to growth in ocean trenches may relate to pressure-related changes in membrane structure in which this complex molecular machine must function. Together, our findings reveal that the habitat expansion of Thaumarchaeota is tightly correlated with extensive horizontal transfer of atp operons
Short Pulse Dynamics in Strongly Nonlinear Dissipative Granular Chains
We study the energy decay properties of a pulse propagating in a strongly
nonlinear granular chain with damping proportional to the relative velocity of
the grains. We observe a wave disturbance that at low viscosities consists of
two parts exhibiting two entirely different time scales of dissipation. One
part is an attenuating solitary wave, is dominated by discreteness and
nonlinearity effects as in a dissipationless chain, and has the shorter
lifetime. The other is a purely dissipative shocklike structure with a much
longer lifetime and exists only in the presence of dissipation. The range of
viscosities and initial configurations that lead to this complex wave
disturbance are explored
A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci
The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1. Here, we show that lysosomal membrane permeabilization (LMP) and cytosolic translocation of activated cathepsin D occur prior to activation of a mitochondrial pathway of macrophage apoptosis. Pharmacological inhibition or knockout of cathepsin D during pneumococcal infection blocked macrophage apoptosis. As a result of cathepsin D activation, Mcl-1 interacted with its ubiquitin ligase Mule and expression declined. Inhibition of cathepsin D had no effect on early bacterial killing but inhibited the late phase of apoptosis-associated killing of pneumococci in vitro. Mice bearing a cathepsin D-/- hematopoietic system demonstrated reduced macrophage apoptosis in vivo, with decreased clearance of pneumococci and enhanced recruitment of neutrophils to control pulmonary infection. These findings establish an unexpected role for a cathepsin D-mediated lysosomal pathway of apoptosis in pulmonary host defense and underscore the importance of apoptosis-associated microbial killing to macrophage function
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