ANTIMICROBIAL POTENCY of Stevia rebaudiana Bertoni as HERBAL MOUTHWASHES AGAINST CARIOGENIC BACTERIAL Streptococcus mutans

Background: Dental caries is a disease that is produced by the dissolution of local chemical surfaces of the teeth caused by product of microbial fermentation from dietary carbohydrates in the biofilm that attached to the teeth. Streptococcus mutans as the primary microbial pathogen in the aetiology of caries. They have a characteristic ability to produce voluminous amounts of sticky, extracellular polysaccharides in the presence of dietary carbohydrates, thus, help tenacious binding of the organism to enamel. Caries can be prevented by regular tooth brushing and flossing as mechanical plaque removal for cleaning the tooth.However, for many individuals, it difficult to eliminate Streptococcus mutans from the surfaces of the tooth by mechanical means alone over prolonged periods. Consequently, for effective caries control, these methods should be combined with the antimicrobial agent such as mouthwash whould have a directinhibitory effect on the microorganism that can be bactericidal or bacteriostatic. However, they have several undesirable side effects reported from clinical studies. The use of medicinal plants is highly considered, because of side effects of chemical substances. Recently, Stevia rebaudiana Bertoni leaves extracts as herbal mouthwashes are being tried and have been scientifically proven from several studies to be safe and effective to protection against dental caries because of its inhibitory effect or antimicrobial property against Streptococcus mutans. Purposes: The main aim of this literature review article is to explain the potenciallyantimicrobial herbal mouthwashes from Stevia rebaudiana Bertoni leaves extracts towards cariogenic bacterial Streptococcus mutans. Conclusions: Stevia rebaudiana Bertoni leaves extracts as herbal mouthwashes can be strongly recommended as a caries preventing agent

The Antifungal Potential of Stevia rebaudiana Bertoni Leaf Extract Against Candida albicans

  Candida sp. are eukaryotic opportunistic pathogens that reside on the mucosa oral cavity, gastrointestinal tract, vagina and sometimes skin. An infection caused by Candida is termed candidiasis or candidosis. Oral candidiasis is a common opportunistic infection of the oral cavity caused by overgrowth of Candida species, the most common being Candida albicans. Risk factor for oral candidiasis are local factors, systemic factors and the physiological states. The most commonly used classes of antifungal drug treatment to Candida infections are the azole, polyenes and echinocandins. However, the management of Candida infections faces many problems, such as toxicity, resistance of Candida to antifungal drugs, relapse to Candida infection and the high cost of antifungal drugs. Many investigators are exploiting alternative therapeutic strategies to overcome problems treating candidiasis. Stevia leaves extracts has been known to have antifungal activity to treat candidiasis. The aim of this review article is to explain antifungal potency of Stevia rebaudiana Bertoni leaves extracts toward Candida albicans. Stevia rebaudiana Bertoni leaves extracts can use as cheap, natural and alternative agent to control candidiasis

UPAYA MEMBIMBING KELUARGA DAN MASYARAKAT MENUJU KELUARGA MANDIRI DI DESA SEI HALIM HASAK KECAMATAN SEI DADAP KABUPATEN ASAHAN

 Pengabdian kepada Masyarakat ini dilaksanakan di Desa Sei Alim Hasak, Kecamatan Sei Dadap, Kabupaten Asahan, Kabupaten Asahan, Sumatera Utara. Pengabdian yang mengangkat tema upaya membimbing keluarga dan masyarakat menuju keluarga mandiri ini bertujuan: (1) untuk memberikan bimbingan dan arahan menuju keluarga mandiri, (2) untuk membagi informasi kepada masyarakat secara luas tentang  upaya menuju keluarga mandiri, (3) untuk memberikan edukasi kepada masyarakat tentang upaya untuk membentuk keluarga mandiri. Pelaksanaan kegiatan ini dilaksanakan pada hari Selasa tanggal 6 Juni 2023. Metode yang dilakukan adalah metode Sosialisasi dengan rincian kegiatan yakni: penganalisaan situasi, penarikan data, melakukan diskusi internal, melakukan observasi, surat-menyurat, mempersiapkan agenda kegiatan, memberikan surat balasan ke desa tujuan. Kegiatan ini berlangsung selama satu hari dengan pemaparan materi dan diskusi yang dibawakan oleh tim pengabdian masyarakat, yaitu (1) Hanina, M.Psi., (2) Drs. Dailami, M.Pd., (3) Dra. Tuti Herawati, M.Pd., (4) Eva Margaretha Saragih, M.Pd., (5) Wan Nurul Atikah Nasution, M.Pd. Masyarakat menunjukkan kebutuhan yang besar atas informasi yang didapatkan dan berharap program-program lainnya berlanjut di desa ini. Pelatihan yang dilakukan oleh para tokoh masyarakat (Kepala Desa beserta jajarannya), pemuda, orang tua, peserta didik dan pendidik mampu menambah pengetahuan bagi kepala rumah tangga/ibu rumah tangga mengenai konsep keluarga mandiri. Kata kunci: Keluarga Mandiri, Masyarakat Mandiri, Pengabdian Masyaraka

Penerapan Pupuk Urea pada Tumpangsari Jagung “Double Row†dan Kacang Tanah Terhadap Pertumbuhan dan Hasil Jagung (Zea mays L.)

The study aims to determine: (1) response growth and result of corn and peanut on monoculture and intercropping; (2) an optimal urea doze on growth and result of corn and peanut. Research did from July to November 2014 in Laboratory of Integrated, Faculty of Agriculture, University of Lampung. The research used complete Random Group Design with Triple Multiply. Homogenity of variance was tested by Bartlett test. Separation of median is done by using the test Polynomial Orthogonal with real level 5 %. The result showed that picking of corn per hectar for monoculture higher than intercropping but the other variable wasn’t really different. Peanut monoculture higher than intercropping for number of pods, weight of 100 grains, and production of seed per hectar but for plant height and greening level, pattern levels of intercropping higher than monoculture, and there were not find an optimal urea doze for corn on intercropping of corn “double row†and peanut. Keywords : corn, intercropping, peanuts, ure

Effect of Hypobaric Hypoxia Induction on Cognitive Function and Glutamate Receptor in Sprague-Dawley Rats

Induction of sublethal hypoxia provides neuroprotective effect pathological processes such as myocardial infarc and stroke. This study aimed to know the effect of intermittent hypobaric hypoxia (IHH) induction on cognitive function and glutamate receptor in the rat brain. The study was conducted at dr. Saryanto Institute for Aviation and Aerospace Health (LAKESPRA) from 2015-2016. 25 sprague dawley rats, divided into 4 IHH treatment groups and 1 control group. Group 1 was induced with 1x IHH exposure, group 2 was induced with 2x IHH exposure, group 3 was induced with 3x IHH exposure and group 4 was induced with 4x IHH exposure (days 1, 8, 15 and 22). After induction, cognitive function tests are performed with Y Maze and immunohistochemistry is performed to evaluate the glutamate receptor N-methyl-D-aspartic acid (NMDA). There were no significant differences between the four treatment groups compared with the control group (p>0.05) on cognitif function, but significant difference in NMDA receptor. In conclution, HHI induction was not cause change cognitive fuction but increased the response of neuroplasticity of sprague-dawley rats brain tissue which assessed from increasing NMDA receptor.&nbsp

Expression of Hypoxia-Inducible Factor-1α and Myoglobin in Rat Heart as Adaptive Response to Intermittent Hypobaric Hypoxia Exposure

The aim of this study was to investigate the influence of intermittent hypobaric hypoxia on the expression hypoxia adaptation proteins, namely hypoxia inducibla factor-1a (HIF-1a) and myoglobin (Mb). Twenty five male Sprague-Dawley rats were exposed to intermittent hypobaric hypoxia in a hypobaric chamber in Indonesian Air Force Institute of Aviation Medicine, for 49.5 minutes at various low pressure, 1 week interval for 4 times (day 1, 8, 15 and 22). HIF-1α and Mb protein were measured with ELISA. mRNA expression of Mb was measured with one step real time RT-PCR. HIF-1α protein levels increased after induction of hypobaric hypoxia and continues to decrease after induction of intermittent hypobaric hypoxia 3 times (ANOVA, p = 0.0437). mRNA expression and protein of Mb increased after induction of hypobaric hypoxia and continues to decrease after induction of intermittent hypobaric hypoxia 3 times (ANOVA, p = 0.0283; 0.0170), and both are strongly correlated (Pearson, r = 0.6307). The heart of rats adapted to intermittent hypoxia conditions by upregulation the expression of HIF-1a and myoglobin and then both return to normal level

lmplementasi Kebijakan Kartu Tanda Penduduk Elektronik (KTP-el)di Kecamatan Putussibau Utara Kabupaten Kapuas Hulu

Pelaksanaan Kebijakan Kartu Tanda Penduduk Elektronik (KTP-el) di Kecamatan Putussibau Utara Kabupaten Kapuas Hulu sampai semester 2 tahun 2014, baru mencapai 79,32% dari jumlah penduduk wajib KTP-el. Sehingga Kecamatan Putussibau Utara masuk dalam kategori Kecamatan yang belum dapat melaksanakan kebijakan perekaman KTP-el secara maksimal. Penelitian ini bertujuan untuk mengetahui Organisasi pelaksana, Interpretasi dan Aplikasi implementasi Kebijakan KTP-el. Pendekatan penelitian ini menggunakan pendekatan deskriptif kualitatif dengan fokus penelitian yaitu mengungkap proses implementasi kebijakan KTP-el di Kecamatan Putussibau Utara Kabupaten Kapuas Hulu dengan mengadakan kajian secara mendalam terhadap Organisasi,Interpretasi dan Aplikasi. Infom1an penelitian terdiri dari pelaksana program (Pemerintah Daerah Kabupaten Kapuas Hulu dan operator pelaksana) serta masyarakat wajib KTP-el. Hasil penelitian menunjukkan bahwa penyebab kurang maksimalnya capaian implementasi perekaman KTP-el di Kecamatan Putussibau Utara adalah: Kantor Camat Putussibau Utara belum melaksanakan tugas pokok dan fungsinya dengan baik, adanya pergantian operator barn dan belum pemah mendapatkan bimbingan teknis, dan masalah transportasi. Berdasarkan hasil temuan penelitian maka: Perlu adanya bimbingan dan pelatihan kepada operator KTP-el secara rutin dan apabila penggantian operator KTP-el di Kecamatan harus dikoordinasikan ke Dinas Kependudukan Catatan Sipil Kabupaten Kapuas Hulu,Kecamatan diberikan wewenang untuk mencetak KTP-el agar penduduk yang berada dipedalaman hanya pergi ke Ibukota Kecamatan dengan begitu penduduk tidak harus mendatangi Dinas Kependudukan dan Pencatatan Sipil yang berada di Kabupaten untuk mengurangi biaya yang akan dikeluarkan oleh penduduk dan memberikan kemudahan bagi penduduk serta mengurangi beban kerja Dinas Kependudukan dan Pencatatan Sipil

Effect of Hypobaric Hypoxia Induction on Cognitive Function and Glutamate Receptor in Sprague-Dawley Rats

Induction of sublethal hypoxia provides neuroprotective effect pathological processes such as myocardial infarc and stroke. This study aimed to know the effect of intermittent hypobaric hypoxia (IHH) induction on cognitive function and glutamate receptor in the rat brain. The study was conducted at dr. Saryanto Institute for Aviation and Aerospace Health (LAKESPRA) from 2015-2016. 25 sprague dawley rats, divided into 4 IHH treatment groups and 1 control group. Group 1 was induced with 1x IHH exposure, group 2 was induced with 2x IHH exposure, group 3 was induced with 3x IHH exposure and group 4 was induced with 4x IHH exposure (days 1, 8, 15 and 22). After induction, cognitive function tests are performed with Y Maze and immunohistochemistry is performed to evaluate the glutamate receptor N-methyl-D-aspartic acid (NMDA). There were no significant differences between the four treatment groups compared with the control group (p>0.05) on cognitif function, but significant difference in NMDA receptor. In conclution, HHI induction was not cause change cognitive fuction but increased the response of neuroplasticity of sprague-dawley rats brain tissue which assessed from increasing NMDA receptor.&nbsp

Expression of Hypoxia-Inducible Factor-1α and Myoglobin in Rat Heart as Adaptive Response to Intermittent Hypobaric Hypoxia Exposure

The aim of this study was to investigate the influence of intermittent hypobaric hypoxia on the expression hypoxia adaptation proteins, namely hypoxia inducibla factor-1a (HIF-1a) and myoglobin (Mb). Twenty five male Sprague-Dawley rats were exposed to intermittent hypobaric hypoxia in a hypobaric chamber in Indonesian Air Force Institute of Aviation Medicine, for 49.5 minutes at various low pressure, 1 week interval for 4 times (day 1, 8, 15 and 22). HIF-1α and Mb protein were measured with ELISA. mRNA expression of Mb was measured with one step real time RT-PCR. HIF-1α protein levels increased after induction of hypobaric hypoxia and continues to decrease after induction of intermittent hypobaric hypoxia 3 times (ANOVA, p = 0.0437). mRNA expression and protein of Mb increased after induction of hypobaric hypoxia and continues to decrease after induction of intermittent hypobaric hypoxia 3 times (ANOVA, p = 0.0283; 0.0170), and both are strongly correlated (Pearson, r = 0.6307). The heart of rats adapted to intermittent hypoxia conditions by upregulation the expression of HIF-1a and myoglobin and then both return to normal level

Proceedings of the 3rd International Conference on Community Engagement and Education for Sustainable Development

This proceeding contains articles on the various ideas of the academic community presented at The 3rd International Conference on Community Engagement and Education for Sustainable Development (ICCEESD 2022) organized by the Universitas Gadjah Mada, Indonesia on 7th-8th December 2022.  ICCEESD is a biannual forum for sharing, benchmarking, and discussing HEI’s activities in developing Education for Sustainable Development towards community engagement. Education for Sustainability as a teaching strategy for resolving community challenges through formal, informal, or non-formal education is expected to benefit from various community service best practices by academics, researchers, and students. The 3rd ICCEESD has “Strengthening Education for Sustainability Towards Better Community Engagement” as its theme this year. It is expected that the 3rd ICCEESD will provide a forum for the presenters and participants to exchange best practices, policies, and conceptual implementation of Education for Sustainability towards better community engagement and explore ideas to address community needs.  Conference Title: 3rd International Conference on Community Engagement and Education for Sustainable DevelopmentConference Theme: Strengthening Education for Sustainability Towards Better Community EngagementConference Acronyms: ICCEESD 2022Conference Date: 7th-8th December 2022Conference Location: Grand Rohan Jogja Yogyakarta, IndonesiaConference Organizer: Universitas Gadjah Mada, Indonesi