882 research outputs found
Low-Lying States of the Six-Dimensional Fractional Superstring
The fractional superstring Fock space is constructed in terms of
\bZ_4 parafermions and free bosons. The bosonization of the \bZ_4
parafermion theory and the generalized commutation relations satisfied by the
modes of various parafermion fields are reviewed. In this preliminary analysis,
we describe a Fock space which is simply a tensor product of \bZ_4
parafermion and free boson Fock spaces. It is larger than the Lorentz-covariant
Fock space indicated by the fractional superstring partition function. We
derive the form of the fractional superconformal algebra that may be used as
the constraint algebra for the physical states of the FSS. Issues concerning
the associativity, modings and braiding properties of the fractional
superconformal algebra are also discussed. The use of the constraint algebra to
obtain physical state conditions on the spectrum is illustrated by an
application to the massless fermions and bosons of the fractional
superstring. However, we fail to generalize these considerations to the massive
states. This means that the appropriate constraint algebra on the fractional
superstring Fock space remains to be found. Some possible ways of doing this
are discussed.Comment: 69 pages, LaTeX, CLNS 91/112
Tree scattering amplitudes of the spin-4/3 fractional superstring I: the untwisted sectors
Scattering amplitudes of the spin-4/3 fractional superstring are shown to
satisfy spurious state decoupling and cyclic symmetry (duality) at tree-level
in the string perturbation expansion. This fractional superstring is
characterized by the spin-4/3 fractional superconformal algebra---a
parafermionic algebra studied by Zamolodchikov and Fateev involving chiral
spin-4/3 currents on the world-sheet in addition to the stress-energy tensor.
Examples of tree scattering amplitudes are calculated in an explicit c=5
representation of this fractional superconformal algebra realized in terms of
free bosons on the string world-sheet. The target space of this model is
three-dimensional flat Minkowski space-time with a level-2 Kac-Moody so(2,1)
internal symmetry, and has bosons and fermions in its spectrum. Its closed
string version contains a graviton in its spectrum. Tree-level unitarity (i.e.,
the no-ghost theorem for space-time bosonic physical states) can be shown for
this model. Since the critical central charge of the spin-4/3 fractional
superstring theory is 10, this c=5 representation cannot be consistent at the
string loop level. The existence of a critical fractional superstring
containing a four-dimensional space-time remains an open question.Comment: 42 pages, 4 figures, latex, IASSNS-HEP-93/57, CLNS-92/117
Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC). The aim of this study was to evaluate the impact of SREs on patients' pain, analgesic use, and pain interference with daily functioning.
METHODS: Data were combined from patients with solid tumors and bone metastases who received denosumab or zoledronic acid across three identically designed phase 3 trials (N = 5543). Pain severity (worst pain) and pain interference were assessed using the Brief Pain Inventory at baseline and each monthly visit. Analgesic use was quantified using the Analgesic Quantification Algorithm.
RESULTS: The proportion of patients with moderate/severe pain and strong opioid use generally increased in the 6 months preceding an SRE and remained elevated, while they remained relatively consistent over time in patients without an SRE. Regression analysis indicated that all SRE types were significantly associated with an increased risk of progression to moderate/severe pain and strong opioid use. PF, RB, and SCC were associated with significantly greater risk of pain interference overall. Results were similar for pain interference with emotional well-being. All SRE types were associated with significantly greater risk of pain interference with physical function.
CONCLUSIONS: SREs are associated with increased pain and analgesic use in patients with bone metastases. Treatments that prevent SREs may decrease pain and the need for opioid analgesics and reduce the impact of pain on daily functioning
Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC). The aim of this study was to evaluate the impact of SREs on patients' pain, analgesic use, and pain interference with daily functioning.
METHODS: Data were combined from patients with solid tumors and bone metastases who received denosumab or zoledronic acid across three identically designed phase 3 trials (N = 5543). Pain severity (worst pain) and pain interference were assessed using the Brief Pain Inventory at baseline and each monthly visit. Analgesic use was quantified using the Analgesic Quantification Algorithm.
RESULTS: The proportion of patients with moderate/severe pain and strong opioid use generally increased in the 6 months preceding an SRE and remained elevated, while they remained relatively consistent over time in patients without an SRE. Regression analysis indicated that all SRE types were significantly associated with an increased risk of progression to moderate/severe pain and strong opioid use. PF, RB, and SCC were associated with significantly greater risk of pain interference overall. Results were similar for pain interference with emotional well-being. All SRE types were associated with significantly greater risk of pain interference with physical function.
CONCLUSIONS: SREs are associated with increased pain and analgesic use in patients with bone metastases. Treatments that prevent SREs may decrease pain and the need for opioid analgesics and reduce the impact of pain on daily functioning
Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro
Although peroxisome proliferator-activated receptor gamma (PPARγ) agonist have been shown to inhibit hepatocellular carcinoma (HCC) development, the role of PPARγ in hepatocarcinogenesis remains unclear. We investigated the therapeutic efficacy of PPAR
Pain outcomes in patients with bone metastases from advanced cancer: assessment and management with bone-targeting agents
Bone metastases in advanced cancer frequently cause painful complications that impair patient physical activity and negatively affect quality of life. Pain is often underreported and poorly managed in these patients. The most commonly used pain assessment instruments are visual analogue scales, a single-item measure, and the Brief Pain Inventory Questionnaire-Short Form. The World Health Organization analgesic ladder and the Analgesic Quantification Algorithm are used to evaluate analgesic use. Bone-targeting agents, such as denosumab or bisphosphonates, prevent skeletal complications (i.e., radiation to bone, pathologic fractures, surgery to bone, and spinal cord compression) and can also improve pain outcomes in patients with metastatic bone disease. We have reviewed pain outcomes and analgesic use and reported pain data from an integrated analysis of randomized controlled studies of denosumab versus the bisphosphonate zoledronic acid (ZA) in patients with bone metastases from advanced solid tumors. Intravenous bisphosphonates improved pain outcomes in patients with bone metastases from solid tumors. Compared with ZA, denosumab further prevented pain worsening and delayed the need for treatment with strong opioids. In patients with no or mild pain at baseline, denosumab reduced the risk of increasing pain severity and delayed pain worsening along with the time to increased pain interference compared with ZA, suggesting that use of denosumab (with appropriate calcium and vitamin D supplementation) before patients develop bone pain may improve outcomes. These data also support the use of validated pain assessments to optimize treatment and reduce the burden of pain associated with metastatic bone disease
Duality Cascade in Brane Inflation
We show that brane inflation is very sensitive to tiny sharp features in
extra dimensions, including those in the potential and in the warp factor. This
can show up as observational signatures in the power spectrum and/or
non-Gaussianities of the cosmic microwave background radiation (CMBR). One
general example of such sharp features is a succession of small steps in a
warped throat, caused by Seiberg duality cascade using gauge/gravity duality.
We study the cosmological observational consequences of these steps in brane
inflation. Since the steps come in a series, the prediction of other steps and
their properties can be tested by future data and analysis. It is also possible
that the steps are too close to be resolved in the power spectrum, in which
case they may show up only in the non-Gaussianity of the CMB temperature
fluctuations and/or EE polarization. We study two cases. In the slow-roll
scenario where steps appear in the inflaton potential, the sensitivity of brane
inflation to the height and width of the steps is increased by several orders
of magnitude comparing to that in previously studied large field models. In the
IR DBI scenario where steps appear in the warp factor, we find that the
glitches in the power spectrum caused by these sharp features are generally
small or even unobservable, but associated distinctive non-Gaussianity can be
large. Together with its large negative running of the power spectrum index,
this scenario clearly illustrates how rich and different a brane inflationary
scenario can be when compared to generic slow-roll inflation. Such distinctive
stringy features may provide a powerful probe of superstring theory.Comment: Corrections in Eq.(5.47), Eq (5.48), Eq(5.49) and Fig
Enhanced strange baryon production in Au+Au collisions compared to p+p at sqrts = 200 GeV
We report on the observed differences in production rates of strange and
multi-strange baryons in Au+Au collisions at sqrts = 200 GeV compared to pp
interactions at the same energy. The strange baryon yields in Au+Au collisions,
then scaled down by the number of participating nucleons, are enhanced relative
to those measured in pp reactions. The enhancement observed increases with the
strangeness content of the baryon, and increases for all strange baryons with
collision centrality. The enhancement is qualitatively similar to that observed
at lower collision energy sqrts =17.3 GeV. The previous observations are for
the bulk production, while at intermediate pT, 1 < pT< 4 GeV/c, the strange
baryons even exceed binary scaling from pp yields.Comment: 7 pages, 4 figures. Printed in PR
Rare missense functional variants at COL4A1 and COL4A2 in sporadic intracerebral Hhmorrhage
Objective:
To test the genetic contribution of rare missense variants in COL4A1 and COL4A2 in which common variants are genetically associated with sporadic intracerebral hemorrhage (ICH), we performed rare variant analysis in multiple sequencing data for the risk for sporadic ICH.
Methods:
We performed sequencing across 559Kbp at 13q34 including COL4A1 and COL4A2 among 2,133 individuals (1,055 ICH cases; 1,078 controls) in US-based and 1,492 individuals (192 ICH cases; 1,189 controls) from Scotland-based cohorts, followed by sequence annotation, functional impact prediction, genetic association testing, and in silico thermodynamic modeling.
Results:
We identified 107 rare nonsynonymous variants in sporadic ICH, of which two missense variants, rs138269346 (COL4A1I110T) and rs201716258 (COL4A2H203L), were predicted to be highly functional and occurred in multiple ICH cases but not in controls from the US-based cohort. The minor allele of rs201716258 was also present in Scottish ICH patients, and rs138269346 was observed in two ICH-free controls with a history of hypertension and myocardial infarction. Rs138269346 was nominally associated with non-lobar ICH risk (P=0.05), but not with lobar ICH (P=0.08), while associations between rs201716258 and ICH subtypes were non-significant (P>0.12). Both variants were considered pathogenic based on minor allele frequency (<0.00035 in EUR), predicted functional impact (deleterious or probably damaging), and in silico modeling studies (substantially altered physical length and thermal stability of collagen).
Conclusions:
We identified rare missense variants in COL4A1/A2 in association with sporadic ICH. Our annotation and simulation studies suggest that these variants are highly functional and may represent targets for translational follow-up
Longitudinal double-spin asymmetry for inclusive jet production in p+p collisions at sqrt(s)=200 GeV
We report a new STAR measurement of the longitudinal double-spin asymmetry
A_LL for inclusive jet production at mid-rapidity in polarized p+p collisions
at a center-of-mass energy of sqrt(s) = 200 GeV. The data, which cover jet
transverse momenta 5 < p_T < 30 GeV/c, are substantially more precise than
previous measurements. They provide significant new constraints on the gluon
spin contribution to the nucleon spin through the comparison to predictions
derived from one global fit of polarized deep-inelastic scattering
measurements.Comment: 7 pages, 4 figures + 1 tabl
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