AT LEVE MED VOLD: Om seksualitet og vold blandt unge i Cape Town

The focus of the article is upon the relation between gender and violence as an aspect of everyday practice. It is suggested that strategies for living with violence inform gender perceptions. The article is based on research in Cape Town, South Africa and consentrates on how adolescents there speak about violence and strategies for safety. South Africa is renowned for high levels of violence such as rape or death by gunfire. Rather than focus on these violent acts from the perspective of either the victim or perpetrator, the focus lies in the implications for the witnesses, who live with the threat of violence in their daily lives. Narratives related to violence and strategies for safety show how violence manifests itself. The authors argue that women and men are discursively informed to respond to and perceive violence differently. Men are agents of violence as protectors and perpetrators, and women are pacified and potential victims. Furthermore the study emphasises that violence maintains patriarchal gender roles and thereby becomes a major barrier to rethinking gender perceptions and gender equality. &nbsp

Arctic Investment Protocol - Guidelines for Responsible Investment in the Arctic

The Arctic is a diverse, rapidly-changing and environmentally sensitive region that is home for its four million residents and also an emerging global investment opportunity. To balance these dimensions, the Investment Protocol of the World Economic Forum Global Agenda Council on the Arctic aspires to promote sustainable and equitable economic growth in the region that furthers community well-being and builds resilient societies in a fair, inclusive and environmentally sound manner

Arctic Investment Protocol

Guidelines for responsible investment in the arcti

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

Functionalized TiO2 nanoparticles by single-step hydrothermal synthesis: the role of the silane coupling agents

A simple, robust and versatile hydrothermal synthesis route to in situ functionalized TiO2 nanoparticles was developed using titanium(IV) isopropoxide as Ti-precursor and selected silane coupling agents (3-aminopropyltriethoxysilane (APTES), 3-(2-aminoethylamino)propyldimethoxymethylsilane (AEAPS), and n-decyltriethoxysilane (DTES)). Spherical nanoparticles (ca. 9 nm) with narrow size distribution were obtained by using DTES or by synthesis performed without silane coupling agents. Rod-like nanoparticles along with 9 nm spherical nanoparticles were formed using aminosilane coupling agents because of a combination of oriented attachment of nanoparticles and specific adsorption of the aminosilane on crystallographic faces of anatase nanoparticles. The nanoparticles were functionalized in situ and became hydrophobic as silanes reacted to form covalent bonds on the surface of TiO2. The versatility of the aqueous synthesis route was demonstrated, and by selecting the type of silane coupling agent the surface properties of the TiO2 nanoparticles could be tailored. This synthesis route has been further developed into a two-step synthesis to TiO2–SiO2 core–shell nanoparticles. Combustion of the silane coupling agents up to 700 °C leads to the formation of a nanometric amorphous SiO2 layer, preventing growth and phase transition of the in situ functionalized nanoparticles

Confinement and restrictive measures against young people in the Nordic countries : A comparative analysis of Denmark, Finland, Norway, and Sweden

This article reviews and compares the use of confinement and other restrictive measures against young people under 18 in child welfare and/or the criminal justice systems in Denmark, Sweden, Finland, and Norway. Young people are confined for a variety of reasons, including protection, care, treatment, and punishment. However, confinement of young people is a contested issue because it can beviewed as necessary but also potentially harmful. Comparison of legislation and practices reveals that while there are some similarities in the service provisions for young people, there are also significant disparities among the four countries regarding the organization, function, and frequency of the use of confinement and restrictive measures. While Denmark and Sweden use secure welfare institutions, Finland and Norway apply other restrictive measures. Despite the differences in approaches to confinement in the Nordic countries, the use of confinement is guided by the principle of the child’s best interest, and the child welfare system is the main frame for confinement and intervention. The article discusses these disparate practices from the perspective of children’s rights and identifies new avenues for research and practice