409 research outputs found

    Firm-Network Characteristics and Economic Robustness to Natural Disasters

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    This article proposes a theoretical framework to investigate economic robustness to exogenous shocks such as natural disasters. It is based on a dynamic model that represents a regional economy as a network of production units through the disaggregation of sectorscale Input-Output tables. Results suggest that disaster-related output losses depend on direct losses heterogeneity and on the economic network structure. Two aggregate indexes, concentration and clustering, appear as important drivers of economic robustness, offering opportunities for robustness-enhancing strategies. Modern industrial organization seems to reduce short-term robustness in a trade-off against higher efficiency in normal times.Natural disasters, Economic impacts, Economic Network.

    Aspergillosis in Chronic Granulomatous Disease

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    Acknowledgments: This work was supported by the Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377 to Jill King and Adilia Warris.Peer reviewedPublisher PD

    Can verbal suggestions strengthen the effects of a relaxation intervention?

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    Short stress management interventions such as relaxation therapy have demonstrated preliminary effectiveness in reducing stress-related problems. A promising tool to strengthen the effectiveness of relaxation-based interventions is the use of verbal suggestions, as previous research provided evidence that verbal suggestions can induce positive outcome expectancies, facilitate adaptive responses to stress and improve health outcomes. The present experimental proof-of-concept study aimed to investigate the effects of a brief relaxation intervention and specifically the role of verbal suggestions on stress-related outcomes assessed by self-report questionnaires and psychophysiological data. 120 participants (mean age = 22.1 years) were randomized to one of four intervention conditions: a brief relaxation intervention plus verbal suggestions condition, a brief relaxation intervention only condition, a verbal suggestions only condition, and a control condition. Afterwards, participants were subjected to a psychosocial stress challenge to assess reactivity to a stressful event. Immediately after both relaxation interventions (with and without verbal suggestions), lower self-reported state anxiety was found compared to the control condition, but no differences were observed in response to the stressor. The verbal suggestions only condition did not impact state anxiety. No significant effects were found for verbal suggestion interventions on cortisol, alpha amylase, heart rate and skin conductance. This is the first study investigating the role of verbal suggestions in the effectiveness of a brief relaxation intervention. Although this experimental proof-of-concept study provides support for the effectiveness of a brief relaxation intervention in lowering state anxiety directly after the intervention, the effects did not impact the response to a subsequent stressor and we did not observe any evidence for the add-on effectiveness of verbal suggestions. The effectiveness of brief relaxation interventions on stress responses should be investigated further in future research by incorporating interventions that are tailored to the specific stress challenge and various types of verbal suggestions

    COCARDE: new view on old mounds – an international network of carbonate mound research

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    EGU2012-12550 Carbonate mounds are important contributors of life in different settings, from warm-water to cold-water environments, and throughout geological history. Research on modern cold-water coral carbonate mounds over the last decades made a major contribution to our overall understanding of these particular sedimentary systems. By looking to the modern carbonate mound community with cold-water corals as main framework builders, some fundamental questions could be addressed, until now not yet explored in fossil mound settings. The international network COCARDE (http://www.cocarde.eu) is a platform for exploring new insights in carbonate mound research of recent and ancient mound systems. The aim of the COCARDE network is to bring together scientific communities, studying Recent carbonate mounds in midslope environments in the present ocean and investigating fossil mounds spanning the whole Phanerozoic time, respectively. Scientific challenges in modern and ancient carbonate mound research got well defined during the ESF Magellan Workshop COCARDE in Fribourg, Switzerland (21.–24.01.2009). The Special Volume Cold-water Carbonate Reservoir systems in Deep Environments – COCARDE (Marine Geology, Vol. 282) was the major outcome of this meeting and highlights the diversity of Recent arbonate mound studies. The following first jointWorkshop and Field Seminar held in Oviedo, Spain (16.–20.09.2009) highlighted ongoing research from both Recent and fossil academic groups integrating the message from the industry. The field seminar focused on mounds from the Carboniferous platform of Asturias and Cantabria, already intensively visited by industrial and academic researchers. However, by comparing ancient, mixed carbonate-siliciclastic mound systems of Cantabria with the Recent ones in the Porcupine Seabight, striking similarities in their genesis and processes in mound development asked for an integrated drilling campaign to understand better the 3D internal mound build-up. The Oviedo Workshop and Field Seminar led to the submission of a White Paper on Carbonate Mound Drilling and the initiation of the ESF European Research Network Programme Cold-Water Carbonate Mounds in Shallow and Deep Time – The European Research Network (COCARDE-ERN) launched in June 2011. The second COCARDE Workshop and Field Seminar was held in Rabat, Morocco (24.–30.10.2011) and thematically focussed on carbonate mounds of(f) Morocco. The compact workshop invited students from Moroccan Universities to experience ongoing carbonate mound research in Recent and Ancient environments of Morocco. Two Round Tables discussed innovative approaches in carbonate mound research in Morocco (Recent vs. Ancient - offshore vs. onshore) and reviewed together with oil industry opportunities of international collaboration. The outcome of this workshop will lead into joint research projects, drilling campaigns on- and offshore, and expansion of COCARDE onto the African continent

    European Collaboration in Ocean Cores Science: roots, highlights, off-springs and vision

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    July 4th, 1947, exactly 75 years after the legendary cruise of H.M.S. Challenger and at a time when ocean science seemed to definitively shift to the shores of Massachusetts and California, the Swedish 5-masted schooner and school-ship Albatross set sail from Göteborg for a 15-months ambitious voyage of circumnavigation of the world oceans. Staffed with cadets and scientists and headed by Hans Pettersson, the Albatross had on board a revolutionary tool: Kullenberg’s piston corer, a 30m-long device which had already allowed the recovery of a 20m-long sediment core. Previously, the Meteor had recovered cores of a maximal length of 0.90m (1925), while in the thirties C.S. Piggot of the Carnegie Institution had “shot” cores up to 3m length in the North-Atlantic with a gun-like device. Sedimentological, geochemical, mineralogical, micropalaeontological analyses and radio-active dating would be carried out not only in Swedish institutes, but also in Vienna, Göttingen, Hanover, Wageningen, Ghent, Paris, London and La Jolla, in the true spirit of the data exploitation scheme which had shaped the success of the cruise of the Challenger. The stage was set for palaeo-environmental research on long sediment cores, archives of past climate and oceans.In the mid-sixties, ocean cores science takes a giant leap with the Deep Sea Drilling Program (DSDP). 20 years after the Albatross, in the fall of 1968, the Glomar Challenger sails from Dakar for the South Atlantic to verify the hypothesis of seafloor spreading and plate tectonics. Europe would join the Ocean Drilling Program (ODP), which set sail in 1984, subsequent to the International Phase of Ocean Drilling (IPOD, 1975-1983). For the first time, the European Science Foundation moves in, providing to numerous smaller European partners a platform of participation in ODP through ECOD, the European Consortium for Ocean Drilling.Some 50 years after the Albatross, the ‘Calypso’ piston corer on board of R/V Marion Dufresne would set the record of piston coring length, with an unrivaled core of over 64m length. The IMAGES programme would boost palaeoclimate research worldwide.At the turn of the century, ECORD - an off-spring of ECOD which had left the parental house - took the lead of the Mission Specific Platform (MSP) scheme in the Integrated Ocean Drilling Program (IODP), pushing frontiers of ocean drilling to extreme environments such as the poles and coral reefs. While not directly involved in the operational aspects, ESF soon took a prominent place in the supporting science, not the least through the EUROCORES programme and research networks.At the onset of the 21st century, while IODP and the international ocean drilling and coring community define a new strategy for post-2013 ocean coring science, Europe moves in with a new revolutionary tool, the MeBo (Meeresboden BohrgerĂ€t), a remotely operated seabed drilling tool capable of drilling and coring from a variety of large vessels. EUROFLEETS provides new opportunities for coordinated naval operations for ocean science. And in parallel, Europe develops the plans for an ambitious drilling platform for the Arctic: Aurora Borealis.Any lucid vision on the future of Ocean Cores Science, which plays a key role in the unraveling of the dynamics of our planet, will build upon the lessons of the past, reflect upon the strengths and weaknesses of the present, and ride upon the excitement of Europe’s young generation, driver of the future

    Tertiary and quaternary geology of the Belgian Continental Shelf

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    A synthesis of the geology of the Belgian continental shelf is here presented. The main part of this document is dedicated to the review of the lithostratigraphy, geotechnical properties, geometry and distribution of the Tertiary and Quaternary deposits. The data compilation, review and assessment have been conducted from the numerous existing studies and large data sets, available offshore, but also onland when offshore data were scarce or lacking. Three main projects have enabled to collect the offshore data: (1) the project “Seismic stratigraphy, Southern Bight, North Sea” (RCMG, City of London Polytechnic/NERC, University of Caen/CNRS); (2) the project “Seismisch onderzoek op het Belgisch Continentaal Plat. Eerste faze. Ontginningszone 2” (MEZ/Administratie van het Mijnwezen, RCMG); (3) the project “Studie oppervlaktelaag van het Belgisch Continentaal Plat. Seismisch prospectie sector B” MEZ/Belgian Geological Survey-BGD, RCMG). Data consist mainly of seismic profiles (16,000 km), cores (79) and cone penetration tests (CPTs, 177). All the data have been digitised and integrated in appropriate georeferenced softwares. Synthetic integrated maps and tables have been produced, aimed to provide the end-users with clear and directly usable information.This synthesis has been conducted in the framework of the project “Optimal Offshore Wind Energy Developments in Belgium”, financed by the Belgian federal government (Federal Office for Scientific, Technical and Cultural Affairs). This project is in keeping with the part I project network “Production patterns and sustainable consumption” of the PADD II program. Objectives of this project consisted in providing recommendations for the selection of sites that are convenient with respect to the stability of offshore wind structures and the minimisation of geo-environmental impacts

    Non-Fickian Diffusion Affects the Relation between the Salinity and Hydrate Capacity Profiles in Marine Sediments

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    On-site measurements of water salinity (which can be directly evaluated from the electrical conductivity) in deep-sea sediments is technically the primary source of indirect information on the capacity of the marine deposits of methane hydrates. We show the relation between the salinity (chlorinity) profile and the hydrate volume in pores to be significantly affected by non-Fickian contributions to the diffusion flux---the thermal diffusion and the gravitational segregation---which have been previously ignored in the literature on the subject and the analysis of surveys data. We provide amended relations and utilize them for an analysis of field measurements for a real hydrate deposit.Comment: 7 pages, 2 figures, 1 table, submitted to Compte Rendus Mecaniqu

    Vif is a RNA chaperone that could temporally regulate RNA dimerization and the early steps of HIV-1 reverse transcription

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    HIV-1 Vif (viral infectivity factor) is associated with the assembly complexes and packaged at low level into the viral particles, and is essential for viral replication in non-permissive cells. Viral particles produced in the absence of Vif exhibit structural defects and are defective in the early steps of reverse transcription. Here, we show that Vif is able to anneal primer tRNALys3 to the viral RNA, to decrease pausing of reverse transcriptase during (–) strand strong-stop DNA synthesis, and to promote the first strand transfer. Vif also stimulates formation of loose HIV-1 genomic RNA dimers. These results indicate that Vif is a bona fide RNA chaperone. We next studied the effects of Vif in the presence of HIV-1 NCp, which is a well-established RNA chaperone. Vif inhibits NCp-mediated formation of tight RNA dimers and hybridization of tRNALys3, while it has little effects on NCp-mediated strand transfer and it collaborates with nucleocapsid (NC) to increase RT processivity. Thus, Vif might negatively regulate NC-assisted maturation of the RNA dimer and early steps of reverse transcription in the assembly complexes, but these inhibitory effects would be relieved after viral budding, thanks to the limited packaging of Vif in the virions

    COCARDE: A research platform for a new look to ancient mounds

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    Carbonate mounds are important contributors of life in different settings, from warm-water to cold-water environments, and throughout geological history. Research on modern carbonate mounds over the last years made a major contribution to our overall understanding of these particular sedimentary systems. By looking to the modern carbonate mound community, some fundamental questions could be addressed, until now not yet explored in fossil mound settings.The international network COCARDE (Cold-Water Carbonate Reservoir Systems in Deep Environment) is a platform for exploring new insights in cold- and warm-water carbonate mound research of recent and ancient mound systems (http://www.cocarde.eu). One aim of the COCARDE network is to bring scientific communities together, to study recent carbonate mounds in midslope environments in the present ocean, and to investigate fossil mounds spanning the whole Phanerozoic time.Scientific challenges on modern and ancient carbonate mound systems got already well defined during two dedicated workshops of the COCARDE network: 1) the ESF Magellan COCARDEWorkshop in Fribourg, Switzerland, January 21-24, 2009, and 2) the ESF MiCROSYSTEMS – FWO COCARDE Flanders – ESF CHECREEF Workshop and Field Seminar, Oviedo, Spain, September 16–20, 2009.The wide spectrum of disciplines in geosciences and biology are summarized in the following five topics for the carbonate mound research: i) Palaeoenvironment; ii) The Microbial Filter; iii) Petrophysical Characterization; iv) Connectivity and Compartmentalization – the Fluid System; v) Advancing our Insight in Phanerozoic Reef Systems– the Slope Niche. One of the most important outcomes of these meetings was the identification of the need for combined research efforts on fossil and modern carbonate settings to provide the baseline reference standard for a better understanding of these exceptional systems and their potential as hydrocarbon reservoirs
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