Desarrollo de habilidades sociales en estudiantes de práctica profesional de la Corporación Universitaria del Caribe, Colombia

Las habilidades sociales son un elemento fundamental en el profesional del siglo XXI porque permiten establecer relaciones interpersonales positivas y desenvolverse en distintos contextos, especialmente en dinámicas laborales. El objetivo del artículo es determinar el nivel de desarrollo de las habilidades sociales de estudiantes en práctica profesional de la Corporación Universitaria del Caribe en Colombia. La metodología tuvo un enfoque cuantitativo, de tipo descriptivo, con diseño no experimental, transversal. La muestra estuvo conformada por 1.098 estudiantes en práctica profesional, usando como técnica la escala de actitudes y opiniones, y como instrumento las Escala de Habilidades Sociales. Los resultados evidencian que los estudiantes matriculados en la práctica profesional poseen un nivel de desarrollo medio de habilidades sociales, indicando que tienen la habilidad de responder frecuentemente de manera positiva en las interacciones con los demás, así también en situaciones donde tengan que expresar una disconformidad o hacer peticiones. En conclusión, los estudiantes en práctica profesional de esta institución universitaria poseen una base sólida de habilidades sociales, esenciales para su desarrollo profesional en el siglo XXI; sin embargo, también se identifica la necesidad de seguir fortaleciendo estas habilidades, especialmente en áreas como la gestión del tiempo, la resiliencia y el manejo del estrés

Primary lung cancer cell culture from transthoracic needle biopsy samples

Artículo de investigación1-14Lung cancer is the leading cause of cancer death in the world. The high mortality rate of this pathology is directly related to its late detection, since its symptoms can be masked by other diseases of lower risk. Although in recent years the number of research related to this subject has increased, molecular mechanisms that trigger this disease remains poorly understood. Experimental models are therefore vital for use in research. Immortalized cell lines have inherent limitations. Explanted tumoral cells obtained by transthoracic needle biopsy can be a potential source of primary culture of human lung tumor cells. Tumor specimens from 14 patients suspected of primary or metastatic lung cancer were obtained by CT-guided transthoracic lung biopsy. Solid tumors were mechanically disaggregated under a stereoscope. Cells were cultured in Base C growth media supplemented with 5% fetal bovine serum in 24-well cell culture plates. Primary lung cancer cell culture was successfully cultured from 12 out of 14 patients. Once a confluent monolayer was obtained, cells were enzymatically harvested and passaged to Petri culture dishes. These primary cell cultures were characterized by cytogenetic tests and gene expression analysis of diagnostic markers. These primary cell cultures revealed chromosome rearrangements and changes in their chromosome complement typical of tumoral cells. Additionally, Fluorescence in situ hybridization analysis demonstrated that three cultures exhibited EGFR amplification. Finally, expression profiles of CK7, NAPSIN A, TTF1, and P63 genes allowed in some cases to confirm sample tumor phenotype. These results demonstrate that primary lung cancer cell culture is possible from percutaneous puncture and provides an important biological source to asses and investigate the molecular mechanisms of lung cancer

Propiedades psicométricas y utilidad diagnóstica del Addenbrooke’s Cognitive Examination-Revised (ACE-R) en una muestra de ancianos chilenos

Artículo de publicación ISIBackground: The Addenbrooke’s Cognitive Examination - Revised (ACE-R) is a good alternative to the Mini Mental State Examination (MMSE) for assessing cognitive capacities in dementia. Aim: To estimate the psychometric properties and diagnostic utility of the Addenbrooke’s Cognitive Examination-Revised (ACE-R) in a Chilean elderly sample. Material and Methods: ACE-R was adapted for the Chilean population (ACE-R-Ch) and then administered to 60 dementia patients, 22 mild cognitive impairment (MCI) patients and 45 control subjects in addition to the MMSE for assessing global cognitive efficiency. Caregivers of dementia patients and collateral sources of MCI patients and elderly subjects without dementia were interviewed with measures of dementia severity, functional status in activities of daily living and cognitive changes. Convergent validity, internal consistency reliability, cutoff points, sensitivity and specificity for ACE-R-Ch were estimated. Results: Regarding convergent validity, the ACE-R-Ch showed significant correlations (p < 0,001) with another cognitive measure (r = 0,952 with MMSE), a rating for dementia severity (Spearman rho=-0,822 with CDR), functional capacity assessments (r = -0,70 with ADLQ-Ch; r = -0,725 with PFAQ-Ch; and r = 0,650 with IADL Scale) and a measure of cognitive changes (r = -0,633 with AD8-Ch). In terms of reliability, the test had a Cronbach alpha coefficient of 0.918. The best cut-off point to distinguish cases of dementia from control subjects was a score of 76, which reached a sensitivity of 0.92 and a specificity of 0.93. Conclusions: The ACE-R-Ch showed acceptable psychometric properties, becoming a valid and reliable instrument to assess global cognitive efficiency or cognitive impairment. Its diagnostic utility to detect dementia patients also worked very well in a Chilean elderly sample

Additional file 1: of A longitudinal analysis of diet quality scores and the risk of incident depression in the SUN Project

Micronutrient intake within the lowest quintile of adherence to different diet quality scores. Suboptimal intakes. (DOC 34 kb

Effect of Zinc Intake on Mental and Motor Development in Infants: A Meta-Analysis

A systematic review and meta-analysis of available randomized controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on mental and motor development in infants. Out of 5500 studies identified through electronic searches and reference lists, 5 RCTs were selected after applying the exclusion/inclusion criteria. The influence of Zn intake on mental and motor development was considered in the overall meta-analysis. Other variables were also taken into account as possible effect modifiers: doses of Zn intake, intervention duration, nutritional situation, and risk of bias. Indices of mental and motor development assessed were the Mental Development Index (MDI) and Psychomotor Development Index (PDI). Additionally we carried out a sensitivity analysis. The pooled β was -0.01 (95 %CI -0.02, 0) for MDI and 0 (95 %CI -0.03, 0.02) for PDI, with a substantial heterogeneity in both analyses. When we performed a meta-regression, the effect of Zn supplementation on MDI changed depending on the dose of supplementation. Regarding PDI, there was a differential effect of Zn intake depending on intervention duration, dose of supplementation, nutritional situation, and risk of bias. Zn supplementation showed a negative, weak and significant effect on PDI score in those studies with a length of 4 to 20 weeks (β= -0.05; CI 95 % -0.06 to -0.04). In conclusion, no association was found between Zn intake and mental and motor development in infants. Further standardized research is urgently needed to clarify the role of Zn supplementation upon infant mental and motor development, particularly in Europe

Avances de la investigación de la comunicación en Venezuela

Coordinadores del Libro-e: Carlos Arcila C. y Mabel Calderín C.1-491La Asociación de Investigadores Venezolanos de la Comunicació[email protected]