(1R,3S)-N-Benzhydryl-2-benzyl-6,7-dimeth­oxy-1-phenyl-1,2,3,4-tetra­hydro­isoquinoline-3-carbothio­amide

The title compound, C38H36N2O2S, has a heterocyclic ring that assumes a half-chair conformation. The phenyl rings of neighbouring mol­ecules align forming alternating chains parallel to [100] within the crystal packing. The absolute stereochemistry of the crystal was confirmed to be R,S at the 1- and 3-positions, respectively, by proton NMR spectroscopy. A single intra­molecular N—H⋯N hydrogen bond is observed

(S)-Benzyl 3-phenyl­carbamoyl-1,2,3,4-tetra­hydro­isoquinoline-2-carboxyl­ate

There are two independent mol­ecules in the asymmetric unit of the title compound, C24H22N2O3. The heterocyclic ring assumes a twisted boat conformation and N—H⋯O inter­actions help to construct the three-dimensional network within the crystal packing

Social Network and Content Analysis of the North American Carbon Program as a Scientific Community of Practice

The North American Carbon Program (NACP) was formed to further the scientific understanding of sources, sinks, and stocks of carbon in Earth's environment. Carbon cycle science integrates multidisciplinary research, providing decision-support information for managing climate and carbon-related change across multiple sectors of society. This investigation uses the conceptual framework of com-munities of practice (CoP) to explore the role that the NACP has played in connecting researchers into a carbon cycle knowledge network, and in enabling them to conduct physical science that includes ideas from social science. A CoP describes the communities formed when people consistently engage in shared communication and activities toward a common passion or learning goal. We apply the CoP model by using keyword analysis of abstracts from scientific publications to analyze the research outputs of the NACP in terms of its knowledge domain. We also construct a co-authorship network from the publications of core NACP members, describe the structure and social pathways within the community. Results of the content analysis indicate that the NACP community of practice has substantially expanded its research on human and social impacts on the carbon cycle, contributing to a better understanding of how human and physical processes interact with one another. Results of the co-authorship social network analysis demonstrate that the NACP has formed a tightly connected community with many social pathways through which knowledge may flow, and that it has also expanded its network of institutions involved in carbon cycle research over the past seven years

(S)-Methyl 3-(3,4-dimeth­oxy­phen­yl)-2-[2-(diphenyl­phosphan­yl)benzamido]­propano­ate

Mol­ecules of the title compound, C31H30NO5P, show a sttagered conformation about the C—C bond joining the dimeth­oxy­benzene group to the chiral centre, with the dimeth­oxy­benzene ring gauche to the amide group and anti to the ester group. In the crystal, weak inter­molecular N—H⋯O and C—H⋯O hydrogen bonds form layers parallel to (110)

Effects of transportation, handling and environment on slaughter cattle. I, Weight loss and carcass yield

Includes bibliographical references (page 11)

(S)-Methyl 2-benzamido-3-(3,4-dimeth­oxy­phen­yl)propano­ate

The dimethoxypbenzene ring in the title compound, C19H21NO5, is gauche to the amide group and anti to the ester group. The chirality was confirmed to be S from two-dimensional NMR spectroscopy. In the crystal, N—H⋯O and C—H⋯O hydrogen bonds and several short-contact inter­actions (2.07–3.45 Å) create chains parallel to [110]. The phenyl ring is disordered over two orientations in a 0.54 (2):0.46 (2) ratio

Discovery of a New Pulsar Wind Nebula in the Large Magellanic Cloud

We present new high-resolution radio and X-ray observations of the supernova remnant (SNR) B0453-685 in the Large Magellanic Cloud, carried out with the Australia Telescope Compact Array and the Chandra X-ray Observatory respectively. Embedded in the SNR shell is a compact central nebula producing both flat-spectrum polarized radio emission and non-thermal X-rays; we identify this source as a pulsar wind nebula (PWN) powered by an unseen central neutron star. We present a new approach by which the properties of a SNR and PWN can be used to infer upper limits on the initial spin period and surface magnetic field of the unseen pulsar, and conclude that this star was an initial rapid rotator with current properties similar to those of the Vela pulsar. As is the case for other similarly-aged sources, there is currently an interaction taking place between the PWN and the SNR's reverse shock.Comment: 4 pages of text plus 2 embedded EPS figures. Minor changes following referee's report. ApJ Letters, in pres

Hsp70 in mitochondrial biogenesis

The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non-native conformations at distinct stages during their life in the cell. In this paper we review work pertaining to the functions of hsp70 proteins in chaperoning mitochondrial protein biogenesis. Hsp70 proteins function in protein synthesis, protein translocation across mitochondrial membranes, protein folding and finally the delivery of misfolded proteins to proteolytic enzymes in the mitochondrial matrix

The Bridgwater Infant Welfare Centre, 1922-1939: from an authoritarian concern with 'welfare mothers' to a more inclusive community health project?

The infant welfare movement in Britain has received considerable scholarly attention but continues to generate controversy and debate. Many of the services began with nineteenth-century voluntary initiative but were later developed by local authorities. Critics have drawn attention to the limitations of such provision; arguing that it was predicated on unattractive assumptions about class and gender roles. Under this interpretation working-class mothers were viewed with suspicion and targeted for advice aimed at inculcating middle-class standards of childcare and housekeeping. This paper accepts that there was an authoritarian character to much of the early welfare work but suggests that over time this gave way to more inclusive approaches that sought to provide clients with the services that met their real rather than assumed needs. This paper reviews the recent historiography, develops an overview of national trends, and then takes a detailed look at the Bridgwater Infant Welfare Centre. The case study benefi ts from unusually comprehensive records and, by drawing on evidence from a small Somerset town, adds to our understanding of infant welfare work that has previously been developed from research on major urban centres.Wellcome Trust Fellowshi

A new interpretation of total column BrO during Arctic spring

Emission of bromine from sea-salt aerosol, frost flowers, ice leads, and snow results in the nearly complete removal of surface ozone during Arctic spring. Regions of enhanced total column BrO observed by satellites have traditionally been associated with these emissions. However, airborne measurements of BrO and O3 within the convective boundary layer (CBL) during the ARCTAS and ARCPAC field campaigns at times bear little relation to enhanced column BrO. We show that the locations of numerous satellite BrO “hotspots” during Arctic spring are consistent with observations of total column ozone and tropopause height, suggesting a stratospheric origin to these regions of elevated BrO. Tropospheric enhancements of BrO large enough to affect the column abundance are also observed, with important contributions originating from above the CBL. Closure of the budget for total column BrO, albeit with significant uncertainty, is achieved by summing observed tropospheric partial columns with calculated stratospheric partial columns provided that natural, short-lived biogenic bromocarbons supply between 5 and 10 ppt of bromine to the Arctic lowermost stratosphere. Proper understanding of bromine and its effects on atmospheric composition requires accurate treatment of geographic variations in column BrO originating from both the stratosphere and troposphere