An experimental testbed for NEAT to demonstrate micro-pixel accuracy

NEAT is an astrometric mission proposed to ESA with the objectives of detecting Earth-like exoplanets in the habitable zone of nearby solar-type stars. In NEAT, one fundamental aspect is the capability to measure stellar centroids at the precision of 5e-6 pixel. Current state-of-the-art methods for centroid estimation have reached a precision of about 4e-5 pixel at Nyquist sampling. Simulations showed that a precision of 2 micro-pixels can be reached, if intra and inter pixel quantum efficiency variations are calibrated and corrected for by a metrology system. The European part of the NEAT consortium is designing and building a testbed in vacuum in order to achieve 5e-6 pixel precision for the centroid estimation. The goal is to provide a proof of concept for the precision requirement of the NEAT spacecraft. In this paper we give the basic relations and trade-offs that come into play for the design of a centroid testbed and its metrology system. We detail the different conditions necessary to reach the targeted precision, present the characteristics of our current design and describe the present status of the demonstration.Comment: SPIE proceeding

Using highly variable warfarin dosing to identify patients at risk for adverse events

<p>Abstract</p> <p>Background</p> <p>Patients who receive highly variable doses of warfarin may be at risk for poor anticoagulation control and adverse events. However, we lack a system to identify patients with the highest dose variability. Our objectives were to develop a scoring system to identify patients with high dose variability, and to validate this new measure by demonstrating that patients so identified have poor anticoagulation control and higher rates of adverse events (criterion validity).</p> <p>Methods</p> <p>We used a database of over 4, 000 patients who received oral anticoagulation in community practice between 2000-2002. We reviewed the charts of 168 patients with large warfarin dose variation and agreed on 18 risk factor definitions for high dose variability. We identified 109 patients with the highest dose variability (cases), as measured by coefficient of variation (CoV, SD/mean). We matched each case to two controls with low dose variability. Then, we examined all 327 charts, blinded to case/control status, to identify the presence or absence of the 18 risk factors for dose variability. We performed a multivariable analysis to identify independent predictors of high CoV. We also compared anticoagulation control, as measured by percent time in therapeutic range (TTR), and rates of adverse events between groups.</p> <p>Results</p> <p>CoV corresponded with other measures of anticoagulation control. TTR was 53% among cases and 79% among controls (p < 0.001). CoV also predicted adverse events. Six cases experienced a major hemorrhage versus 1 control (p < 0.001) and 3 cases had a thromboembolic event versus 0 control patients (p = 0.04). Independent predictors of high dose variability included hospitalization (OR = 21.3), decreased oral intake (OR = 12.2), use of systemic steroids (OR = 6.1), acetaminophen (OR = 4.0) and antibiotics (OR = 2.7; p < 0.05 for all).</p> <p>Conclusion</p> <p>CoV can be used to identify patients at risk for poor anticoagulation control and adverse events. This new measure has the potential to identify patients at high risk before they suffer adverse events.</p

Stellar populations -- the next ten years

The study of stellar populations is a discipline that is highly dependent on both imaging and spectroscopy. I discuss techniques in different regimes of resolving power: broadband imaging (R~4), intermediate band imaging (R~16, 64), narrowband spectral imaging (R~256, 1024, 4096). In recent years, we have seen major advances in broadband all-sky surveys that are set to continue across optical and IR bands, with the added benefit of the time domain, higher sensitivity, and improved photometric accuracy. Tunable filters and integral field spectrographs are poised to make further inroads into intermediate and narrowband imaging studies of stellar populations. Further advances will come from AO-assisted imaging and imaging spectroscopy, although photometric accuracy will be challenging. Integral field spectroscopy will continue to have a major impact on future stellar population studies, extending into the near infrared once the OH suppression problem is finally resolved. A sky rendered dark will allow a host of new ideas to be explored, and old ideas to be revisited.Comment: Invited review, IAUS 241, "Stellar Populations as Building Blocks of Galaxies," eds. Vazdekis, Peletier. 12 pages, 1 table. (The sideways table should print ok; there are 10 columns.

On the black hole content and initial mass function of 47 Tuc

The globular cluster (GC) 47 Tuc has recently been proposed to host an intermediate-mass black hole (IMBH) or a population of stellar-mass black holes (BHs). To shed light on its dark content, we present an application of self-consistent multimass models with a varying mass function and content of stellar remnants, which we fit to various observational constraints. Our best-fitting model successfully matches the observables and correctly predicts the radial distribution of millisecond pulsars and their gravitational accelerations inferred from long-term timing observations. The data favours a population of BHs with a total mass of $430^{+386}_{-301}$ $M_{\odot}$, but the most likely model has very few BHs. Since our models do not include a central IMBH and accurately reproduce the observations, we conclude that there is currently no need to invoke the presence of an IMBH in 47 Tuc. The global present-day mass function inferred is significantly depleted in low-mass stars (power-law slope $\alpha=-0.52^{+0.17}_{-0.16}$). Given the orbit and predicted mass-loss history of this massive GC, the dearth of low-mass stars is difficult to explain with a standard initial mass function (IMF) followed by long-term preferential escape of low-mass stars driven by two-body relaxation, and instead suggests that 47 Tuc may have formed with a bottom-light IMF. We discuss alternative evolutionary origins for the flat mass function and ways to reconcile this with the low BH retention fraction. Finally, by capturing the effect of dark remnants, our method offers a new way to probe the IMF in a GC above the current main-sequence turn-off mass, for which we find a slope of $-2.49\pm0.08$.Comment: 16 pages, 7 figures, accepted to MNRAS after minor revisio

First experimental results of very high accuracy centroiding measurements for the neat astrometric mission

NEAT is an astrometric mission proposed to ESA with the objectives of detecting Earth-like exoplanets in the habitable zone of nearby solar-type stars. NEAT requires the capability to measure stellar centroids at the precision of 5e-6 pixel. Current state-of-the-art methods for centroid estimation have reached a precision of about 2e-5 pixel at two times Nyquist sampling, this was shown at the JPL by the VESTA experiment. A metrology system was used to calibrate intra and inter pixel quantum efficiency variations in order to correct pixelation errors. The European part of the NEAT consortium is building a testbed in vacuum in order to achieve 5e-6 pixel precision for the centroid estimation. The goal is to provide a proof of concept for the precision requirement of the NEAT spacecraft. In this paper we present the metrology and the pseudo stellar sources sub-systems, we present a performance model and an error budget of the experiment and we report the present status of the demonstration. Finally we also present our first results: the experiment had its first light in July 2013 and a first set of data was taken in air. The analysis of this first set of data showed that we can already measure the pixel positions with an accuracy of about 1e-4 pixel.Comment: SPIE conference proceeding

Globular cluster number density profiles using Gaia DR2

Using data from Gaia DR2, we study the radial number density profiles of the Galactic globular cluster sample. Proper motions are used for accurate membership selection, especially crucial in the cluster outskirts. Due to the severe crowding in the centres, the Gaia data is supplemented by literature data from HST and surface brightness measurements, where available. This results in 81 clusters with a complete density profile covering the full tidal radius (and beyond) for each cluster. We model the density profiles using a set of single-mass models ranging from King and Wilson models to generalised lowered isothermal limepy models and the recently introduced spes models, which allow for the inclusion of potential escapers. We find that both King and Wilson models are too simple to fully reproduce the density profiles, with King (Wilson) models on average underestimating(overestimating) the radial extent of the clusters. The truncation radii derived from the limepy models are similar to estimates for the Jacobi radii based on the cluster masses and their orbits. We show clear correlations between structural and environmental parameters, as a function of Galactocentric radius and integrated luminosity. Notably, the recovered fraction of potential escapers correlates with cluster pericentre radius, luminosity and cluster concentration. The ratio of half mass over Jacobi radius also correlates with both truncation parameter and PE fraction, showing the effect of Roche lobe filling.Comment: 23 pages, 23 figures. Accepted in MNRA

A detector interferometric calibration experiment for high precision astrometry

Context: Exoplanet science has made staggering progress in the last two decades, due to the relentless exploration of new detection methods and refinement of existing ones. Yet astrometry offers a unique and untapped potential of discovery of habitable-zone low-mass planets around all the solar-like stars of the solar neighborhood. To fulfill this goal, astrometry must be paired with high precision calibration of the detector. Aims: We present a way to calibrate a detector for high accuracy astrometry. An experimental testbed combining an astrometric simulator and an interferometric calibration system is used to validate both the hardware needed for the calibration and the signal processing methods. The objective is an accuracy of 5e-6 pixel on the location of a Nyquist sampled polychromatic point spread function. Methods: The interferometric calibration system produced modulated Young fringes on the detector. The Young fringes were parametrized as products of time and space dependent functions, based on various pixel parameters. The minimization of func- tion parameters was done iteratively, until convergence was obtained, revealing the pixel information needed for the calibration of astrometric measurements. Results: The calibration system yielded the pixel positions to an accuracy estimated at 4e-4 pixel. After including the pixel position information, an astrometric accuracy of 6e-5 pixel was obtained, for a PSF motion over more than five pixels. In the static mode (small jitter motion of less than 1e-3 pixel), a photon noise limited precision of 3e-5 pixel was reached

SNIFS: a wideband integral field spectrograph with microlens arrays

Supernova