The automatic detection of heart failure using speech signals

Heart failure (HF) is a major global health concern and is increasing in prevalence. It affects the larynx and breathing - thereby the quality of speech. In this article, we propose an approach for the automatic detection of people with HF using the speech signal. The proposed method explores mel-frequency cepstral coefficient (MFCC) features, glottal features, and their combination to distinguish HF from healthy speech. The glottal features were extracted from the voice source signal estimated using glottal inverse filtering. Four machine learning algorithms, namely, support vector machine, Extra Tree, AdaBoost, and feed-forward neural network (FFNN), were trained separately for individual features and their combination. It was observed that the MFCC features yielded higher classification accuracies compared to glottal features. Furthermore, the complementary nature of glottal features was investigated by combining these features with the MFCC features. Our results show that the FFNN classifier trained using a reduced set of glottal + MFCC features achieved the best overall performance in both speaker-dependent and speaker-independent scenarios. (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase

Erb-B2 receptor tyrosine kinase 4 (ErbB4) is a kinase that can signal via a proteolytically released intracellular domain (ICD) in addition to classical receptor tyrosine kinase-activated signaling cascades. Previously, we have demonstrated that ErbB4 ICD is posttranslationally modified by the small ubiquitin-like modifier (SUMO) and functionally interacts with the PIAS3 SUMO E3 ligase. However, direct evidence of SUMO modification in ErbB4 signaling has remained elusive. Here, we report that the conserved lysine residue 714 in the ErbB4 ICD undergoes SUMO modification, which was reversed by sentrin-specific proteases (SENPs) 1, 2, and 5. Although ErbB4 kinase activity was not necessary for the SUMOylation, the SUMOylated ErbB4 ICD was tyrosine phosphorylated to a higher extent than unmodified ErbB4 ICD. Mutation of the SUMOylation site compromised neither ErbB4-induced phosphorylation of the canonical signaling pathway effectors Erk1/2, Akt, or STAT5 nor ErbB4 stability. In contrast, SUMOylation was required for nuclear accumulation of the ErbB4 ICD. We also found that Lys-714 was located within a leucine-rich stretch, which resembles a nuclear export signal, and could be inactivated by site-directed mutagenesis. Furthermore, SUMOylation modulated the interaction of ErbB4 with chromosomal region maintenance 1 (CRM1), the major nuclear export receptor for proteins. Finally, the SUMO acceptor lysine was functionally required for ErbB4 ICD-mediated inhibition of mammary epithelial cell differentiation in a three-dimensional cell culture model. Our findings indicate that a SUMOylation-mediated mechanism regulates nuclear localization and function of the ICD of ErbB4 receptor tyrosine kinase

Five areas to advance branding theory and practice

The paper suggests five areas to advance branding theory and practice based on the authors’ recent work in brand management. In this commentary, we aim to put forward suggestions and ideas for further research in brand management; ideas, which we believe will have an impact on the way branding is researched and practiced by both academics and practitioners alike. We will focus on the future of branding in the following areas, inspired by our own work in the field: (1) branding in higher education, (2) branding in Asia Pacific, (3) brand ambidexterity, (4) brand innovation on social media, and (5) brand likeability

Proposal, project, practice, pause: developing a framework for evaluating smart domestic product engagement

Smart homes are fast becoming a reality, with smart TVs, smart meters and other such “smart” devices/systems already representing a substantial household presence. These, which we collectively term “smart domestic products” (SDPs), will need to be promoted, adopted, and normalized into daily routines. Despite this, the marketing canon lacks a substantive discourse on pertinent research. We look to help correct this by melding ideas from organizational sociology, innovation diffusion and appropriation studies, and service dominant logic. Consequently, we suggest a framework for research that responds directly to the specific characteristics of SDPs. Using the SDP eco-system as a context, our framework emphasizes the interplay of embeddedness, practice, value and engagement. It comprises a four-stage horizontal/ longitudinal axis we describe as proposal, project, practice and pause. Cross-sectionally we focus on value, and combine aspects of existing thought to suggest how this impacts each stage of our engagement continuum. We subsequently identify perceived personal advantage as the resultant of these two axes and propose this as the key for understanding consumer and SDP sociomaterial engagement. This article also advances a definition of SDPs and ends with an agenda for further research

Understanding Co-Production in Service Recovery Processes

Bilstein N, Matta SM, Hogreve J. Understanding Co-Production in Service Recovery Processes. In: Mickelsson J, Helkkula A, eds. Innovative Service Perspectives. Proceedings from the AMA SERVSIG International Service Research Conference. Helsinki: Hanken School of Economics; 2012: 92

Improving value-awareness through storytelling in user experience design

\u3cp\u3eValue has been one of the topics in HCI and design field with various definitions from perspectives. Values are in essence related to experience because they are personal perception and assessment on objects, products, or services. Hence, it makes sense to involve values in user experience design and make values as one of the design goals. However, values are usually easy to take for granted but hard to work with in design practices. This paper proposed a storytelling-value approach with the aim to improve awareness of values in user experience design. It was based on storytelling methodology that emphasizes scenario-based envisioning and the results from a focus group which involved user experience designer in to discuss values in UX design. A co-design workshop was conducted as a support for improvement of the approach. It is promising to optimize this storytelling-value approach in the future since most of the participants showed their positive attitudes not only to the necessity in methods development but also to the acceptance of this approach.\u3c/p\u3

How Are Negative Customer Experiences Formed? A Qualitative Study of Customers’ Online Shopping Journeys

This study investigates how negative customer experiences are formed during customers’ online shopping journeys. A qualitative, in-depth dataset collected from 34 participants was employed to identify negatively perceived touchpoints that contribute to the customer experience in a negative way. The findings reveal that negative touchpoints are experienced during customers’ entire journeys, particularly after a purchase is completed. We identified 152 negative touchpoints from the data, of which 53 were experienced during search and consideration, 35 when finalizing a purchase, 33 during delivery, and 31 during after-sales interactions with the company. Within these four main categories, 20 subthemes describing the touchpoints and formation of customers’ negative experiences were identified therein. The findings highlight the importance of understanding the holistic customer experience formation, including the before- and after-purchase phases of the online shopping journey. In practice, the findings can be utilized in online service design and improvement.peerReviewe