The Effect of Workplace Characteristics on Millennial Worker Organizational Commitment

Existing research on the Millennial generation has focused on identifying the workplace attributions and stereotypes between generations, and the relationship between those attributions and stereotypes, as related to organizational commitment. However, research has not addressed which workplace characteristics influence organizational commitment of the Millennial generation. Herzberg\u27s 2-factor theory was used to investigate the relationship between workplace characteristics and organizational commitment of the Millennial generation. The purpose of this quantitative study was to determine whether workplace characteristics influence organizational commitment in the Millennial generation. This quantitative study used the Minnesota Satisfaction Questionnaire and the Organizational Commitment Questionnaire. A convenience sample of 215 individuals born between 1984 and 1998 were surveyed. The key research questions investigated which workplace characteristics had the greatest impact on organizational commitment. The results indicated that self-management of career paths, combined with opportunities for employee development provided the best predictors for organizational commitment of the Millennial generation. These 2 variables accounted for 21% of the variance of the OCQ (R = .463, R²=.21).By understanding which workplace characteristics impact organizational commitment, organizations will be able to reduce turnover, employees will become more committed to the organization, which may provide employers with a greater opportunity to develop future leaders of their organizations and thereby initiate positive social change at the level of the individual employee and the organization

Expression of p16 in sporadic primary uveal melanoma

Expression of p16 protein, intragenic mutations of CDKN2A and hypermethylation of CDKN2A promoter region in 41 sporadic primary uveal melanomas were studied. There were 2 cases of spindle cell B histological type, 11 of A + B and 28 of mixed type. All melanomas infiltrated sclera but in 28 cases infiltration was superficial while in 13 profound. In 7 cases the tumor infiltrated the optic nerve. Expression of p16 was studied by immunohistochemistry and recorded by assessment of the proportion of positive tumor cells and staining intensity. Results were expressed as staining index (IRS). Intragenic mutations were studied by PCR-SSCP followed by sequencing, while hypermethylation of the promoter region by CpG methylation assay. In 15% of cases less than 10% of melanoma cells were p16 positive, in 70% of cases less than 50% of cells, while in 7% more than 80% of cells stained for p16 (mean IRS for all cases was 4.87 ± 2.43). In B type the IRS was 8.5 ± 0.7, in A + B type 6.0 ± 2.1 and in the mixed type 4.17 ± 2.43 (differences statistically significant). In melanomas profoundly infiltrating sclera mean IRS was 4.16, while in those infiltrating optic nerve 3.71 (statistically not significant). Analysis of the intragenic mutations revealed in two patients a GAC/GAT substitution in codon 84 - a silent mutation. No hypermethylation of the CpG island of the p16 promoter region was found. In conclusion, we found that the degree of p16 expression is related to the histological type of tumor but not to the histological indicators of tumor invasiveness and that intragenic mutations and promoter hypermethylation are not major mechanisms of p16 inactivation in sporadic uveal melanoma

[Projektierte Verbindungsstrasse zwischen Hirschengraben und Rämistrasse]

A. Heizman, XII 74.WestorientiertBasierend auf J.J. Hofe

Disputatio Juridica De Actionibus : Qvam ... In Alma Cæsarea Archiducali Friburgensium Brisgoia Universitate ...

publicè propugnandam exhibuit Franciscus Dominicus Jgnatius Comes a Pötting ... ; Sub Præsidio ... Joannis Georgii Heizman ... ; Die Junij [...] M. DC. LXXIV.Dissertation Universität Freiburg i. Br. 1674Aus dem Vorbesitz des Klosters Rheina

Dark-cell areas in the dog vestibular endorgans: an immunohistochemical study

The stria vascularis in the cochlea and the dark-cell areas in the vestibular endorgans are structures involved in the production of endolymphatic fluid. This study investigated the dark-cell areas in the vestibular endorgans of the dog by classical staining and by immunohistochemistry (anti-Na,K-ATPase ß2 isoform, anti-cytokeratins (against cytokeratins 5 and 8), antivimentin and anti-S100A6) from birth to 110 postnatal days. Using classical staining, it was not possible to discriminate dark cells from other epithelial cells lining the vestibular endolymphatic spaces. From birth, the Na,K-ATPase ß2 isoform was expressed in the lateral and basal cell membranes of a subset of cells located in the utricular wall, at the base of the cristae ampullaris and was identified as dark cells. From birth, anticytokeratins labelled all the cells forming the epithelial lining, including the dark cells, while anti-vimentin labelled the underlying mesenchymal cells. From postnatal day 10, anti-S100A6 labelled subepithelial cells exclusively located underneath the dark-cell areas and were identified as vestibular melanocyte-like cells. From birth, Fontana staining evidenced fine melanin granules in the subepithelial layer. The amount of melanin granules increased during the first month. Melanin distribution was closely associated with the region where S100A6-positive cells were located. The cell-specific antigen expression in the dog darkcell areas was clearly comparable to that of the dog stria vascularis previously described. The present investigation also suggested an earlier histological and immunohistological maturity in the dark-cell areas than in the stria vascularis of dogs. This preliminary morphological description of the normal dark-cell areas in dogs by means of immunomarkers may be instrumental in studying pathological processes involving the fluid-secreting structures in vestibular endorgans