Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass

Objectives: The investigation centers on whether there is a reperfusion-induced specific cardiac inflammatory reaction after bypass surgery. Background: Cardiopulmonary bypass (CPB) leads to systemic inflammation. Additionally, cardiac inflammation due to reperfusion could occur. Knowledge about nature and time course of this reaction might help to develop cardioprotective interventions. Methods: In 12 patients receiving coronary bypass grafts, arterial and coronary venous blood was obtained before onset of CPB, and 1, 5, 10, 25, 35 and 75 min after cardiac reperfusion. Plasma levels of IL6 and IL8 were measured by immunoassay. CD11b, CD41, and CD62 on blood cells were quantified by flow cytometry. Measurement of CD41, a platelet marker, on neutrophils and monocytes allowed detection of leukocyte–platelet microaggregates. Results: Transcardiac veno–arterial difference of IL6 rose in the 10th and 25th min of reperfusion (from 0 to 7 pg/ml; p<0.05), and after 75 min (15 pg/ml). IL8 did not change. CD11b on neutrophils (PMN) decreased transcardially to 95, 88 and 82% of the initial level in the 5th, 10th, and 75th min, respectively, suggesting sequestration of activated neutrophils. CD62 on platelets rose about 30% in the 75th min. Initially, leukocyte–platelet microaggregates were formed during coronary passage (+31% of the arterial level for PMN, +23% for monocytes). During reperfusion, coaggregates were retained (PMN: -1% and -7% in the 5th and 10th min, monocytes: -22%, -13% and -12% in the 1st, 5th and 10th min. Conclusions: During early reperfusion after aortic declamping, the coronary bed is already a source of proinflammatory stimuli and target for activated leukocytes, partly in conjunction with platelets. Mitigation of these phenomena might help to improve cardiac function after CPB especially in patients at risk

Mittelstandsfinanzierung: Rahmenbedingungen, Status Quo und Entwicklung

Small and midcap companies are the backbone of the German economy with respect to employment, contribution to GDP, tax payments, share at world market, innovation – to mention just a few. Hence, it is important that economic and political conditions are favorable for small and midsize enterprises. The article takes a closer look at the funding conditions for companies of the non-financial sector using data starting 2002 analyzing the usage of bank loans and turnover. The statistical outcome suggests that there is often a strong correlation between bank loans and turnover. However, it also suggests the traditional funding from banks is becoming less important and direct funding instruments using capital markets becoming more important

Das Studium der Personalwirtschaft: Anforderungen der Praxis und Hochschulangebote

Personalarbeit gewinnt im Zuge des demografischen Wandels zunehmend an Bedeutung. Personalentwicklung, Rekrutierung von gut ausgebildeten Fachkräften, Nutzung von sozialen Netzwerken und Erhaltung der Beschäftigungsfähigkeit von älteren Arbeitnehmern werden die Schwerpunktthemen von Personalmanagern in diesem Jahrzehnt sein.Daher ist es wichtig, gut ausgebildete Personalmanager zu beschäftigen

Evidence of unrelaxed IGM around IC1262

AIMS: A peculiar morphology of the hot gas was discovered at the center of IC1262 with the ROSAT HRI. Sensitive Chandra and XMM-Newton data were requested to investigate the characteristics of this structure to understand its nature. METHODS: We have exploited the high resolution and sensitivity of Chandra's ACIS-S to investigate the peculiar morphology and spectral characteristics of hot gas in the group around IC1262. XMM-Newton data are only partially usable due to very heavy high background contamination, but they are useful to confirm and strengthen the results from Chandra. RESULTS: The Chandra data show a quite dramatic view of the \object{IC1262} system: a sharp discontinuity east of the central galaxy, with steep drops and a relatively narrow feature over 100 kpc long, plus an arc/loop to the N, are all indicative of a turmoil in the high energy component. Their morphologies could suggest them to be tracers of shocked material caused either by peculiar motions in the system or by a recent merger process, but the spectral characteristics indicate that the structure is cooler than its surroundings. The lack of evidence of significant structures in the velocity distribution of the group members and the estimated scale of the phenomenon make the interpretation of its physical nature challenging. We review a few possible interpretations, in light of similar phenomena observed in clusters and groups. The ram pressure stripping of a bright spiral galaxy, now near the center of the group, is a promising interpretation for most of the features observed. The relation with the radio activity requires a better sampling of the radio parameters that can only be achieved with deeper and higher resolution observations.Comment: Accepted for pubblication in Astronomy & Astrophysics. Figs 1, 2, 3 and 9-12 are given as JPEG files due to the restrictions on space available on astro-p

On the spectro-photometric properties of the bulk of the radio-loud AGN population

In a previous paper we showed that the radio sources selected by combining large areas radio and optical surveys, present a strong deficit of radio emission with respect to 3CR radio-galaxies matched in line emission luminosity. We argued that the prevalence of sources with luminous extended radio structures in high flux limited samples is due to a selection bias. Sources with low radio power form the bulk of the radio-loud AGN population but are still virtually unexplored. We here analyze their photometric and spectroscopic properties. From the point of view of their emission lines, the majority of the sample are Low Excitation Galaxies (LEG), similar to the 3CR objects at the same level of line luminosity. The hosts of LEG are red, massive Early-Type Galaxies (ETG) with large black holes masses , statistically indistinguishable from the hosts of low redshift 3CR/LEG sources. No genuine radio-loud LEG could be found associated with black holes with a mass substantially lower than 10^8 M(sun) or with a late type host. The fraction of galaxies with signs of star formation (5%) is similar to what is found in both the quiescent ETG and 3CR/LEG hosts. We conclude that the deficit in radio emission cannot be ascribed to differences in the properties of their hosts. We argue that instead this could be due to a temporal evolution of the radio luminosity. A minority (10%) of the sample show rather different properties, being associated with low black hole masses, with spiral galaxies, or showing a high excitation spectrum. In general these outliers are the result of the contamination from Seyfert and from galaxies where the radio emission is powered by star formation. For the objects with high excitation spectra there is no a clear discontinuity in either the host or nuclear properties as they span from radio-quiet and radio-loud AGN.Comment: Accepted for publication in A&

Rhabdomyolysis: a genetic perspective

Rhabdomyolysis (RM) is a clinical emergency characterized by fulminant skeletal muscle damage and release of intracellular muscle components into the blood stream leading to myoglobinuria and, in severe cases, acute renal failure. Apart from trauma, a wide range of causes have been reported including drug abuse and infections. Underlying genetic disorders are also a cause of RM and can often pose a diagnostic challenge, considering their marked heterogeneity and comparative rarity. In this paper we review the range of rare genetic defects known to be associated with RM. Each gene has been reviewed for the following: clinical phenotype, typical triggers for RM and recommended diagnostic approach. The purpose of this review is to highlight the most important features associated with specific genetic defects in order to aid the diagnosis of patients presenting with hereditary causes of recurrent RM.</p

Organizational Mortality of Small Firms: The Effects of Entrepreneurial Age and Human Capital

This paper addresses the issue of internal determination of organizational outcomes. It is argued that in small and simply structured organizations a considerable proportion of the variance in organizational activities and outcomes is associated with individuals. In particular, the paper uses human capital theory to derive hypotheses about individual determinants of organizational mortality. These hypotheses are tested with event-history data of firm registrations and de-registrations in a West German region. The hypotheses are corroborated by the data, but the effects may nonetheless be due to processes linking individual characteristics with organizational performance other than those suggested by the human capital approach

European Research Center for Information Systems (ERCIS):Gründungsveranstaltung Münster, 12. Oktober 2004

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LEED Holography applied to a complex superstructure: a direct view of the adatom cluster on SiC(111)-(3x3)

For the example of the SiC(111)-(3x3) reconstruction we show that a holographic interpretation of discrete Low Energy Electron Diffraction (LEED) spot intensities arising from ordered, large unit cell superstructures can give direct access to the local geometry of a cluster around an elevated atom, provided there is only one such prominent atom per surface unit cell. By comparing the holographic images obtained from experimental and calculated data we illuminate validity, current limits and possible shortcomings of the method. In particular, we show that periodic vacancies such as cornerholes may inhibit the correct detection of the atomic positions. By contrast, the extra diffraction intensity due to slight substrate reconstructions, as for example buckling, seems to have negligible influence on the images. Due to the spatial information depth of the method the stacking of the cluster can be imaged down to the fourth layer. Finally, it is demonstrated how this structural knowledge of the adcluster geometry can be used to guide the dynamical intensity analysis subsequent to the holographic reconstruction and necessary to retrieve the full unit cell structure.Comment: 11 pages RevTex, 6 figures, Phys. Rev. B in pres