Optoacoustically induced auditory brainstem responses in the mouse model enhanced through an absorbing film

Significance: Optoacoustic stimulation offers an alternative stimulation strategy for the hearing organ. To serve as the base for a novel auditory prosthesis, the optoacoustic stimulation must be biocompatible and energy-saving. Aim: Enhancing the efficiency of optoacoustic stimulation while reducing the energy input in a suited animal model. Approach: Optoacoustically induced auditory brainstem responses (oABRs) were recorded after the pulsed laser irradiation of the tympanic membrane (TM) in mice. The results were compared with the ABRs induced through acoustic click stimulation. In addition, self-adhesive absorbing films were applied on the TM before the optoacoustic stimulation to investigate their effect on the resulting ABRs. Results: Using an absorbing film on the TM during optical stimulation led to considerably enhanced oABR wave I amplitude values compared with the stimulation of the bare TM. When using our stimulation strategy, we induced oABR waves in the 50% to 60% range of the acoustical stimulation reached with 80-dB SPL click stimuli. Conclusions: The mouse model can be used for certain developmental work for an optoacoustic auditory prosthesis. Using absorbing films on the TM during optical stimulation considerably enhances oABR wave I amplitude. Optimization of the stimulation strategy could further enhance the efficiency within biocompatibility margins

History of economic doctrines, an introduction to economic theory

ix, 263 p.; 23 cm

History Of Economic Doctrines : an introduction to economic theory

ix, 263 hal.; 21c

History Of Economic Doctrines

ix,263 hal,;20 c

History of economic doctrines: an introduction to economic theory

IX+263hlm.;21c

Hugo Heimann in memoriam : Speeches at the funeral services held in New York, Feb. 25, 1951.

digitizedHugo Heimann (1859-1951) was a German publisher and high ranking politician affiliated with the Social Democratic Party in Germany (SPD). Shortly after the Nazis’ rise to power he immigrated to New York via England

The need for a holistic view on management of Clostridioides difficile infection

Molecular basis of bacterial pathogenesis, virulence factors and antibiotic resistanc