Thompson Island: Learning By Doing

Thompson Island has provided unique and outstanding educational services to young people for more than 150 years. The following narrative and historical photographs chronicle how five successive organizations have each pursued the original goal of using the island\u27s remarkable resources to improve the lives of youth from Boston and the surrounding area.A continuous Board of Trustees has governed the island during the past century and a half. Currently, the resident organization is known as the Thompson Island Outward Bound Education Center. Although it is new to the island, Outward Bound is proud to carry on the progressive traditions described in this booklet by offering challenging hands-on learning experiences to many of Boston\u27s most deserving youth. We plan to develop the island into a place as well known and respected as it was in centuries past, with a program revised to fit the needs of the 21st century. We trust that these pages will reveal to you the sources of inspiration and the rewards that have motivated so many Thompson Island supporters in the past, and encourage you to join our new generation of friends for this enduring urban treasure. From an introduction by the Board of Trustees for the Thompson Island Outward Bound Education Center, 199

Respectful leadership:Reducing performance challenges posed by leader role incongruence and gender dissimilarity

We investigate how respectful leadership can help overcome the challenges for follower performance that female leaders face when working (especially with male) followers. First, based on role congruity theory, we illustrate the biases faced by female leaders. Second, based on research on gender (dis-)similarity, we propose that these biases should be particularly pronounced when working with a male follower. Finally, we propose that respectful leadership is most conducive to performance in female leader–male follower dyads compared with all other gender configurations. A multi-source field study (N = 214) provides partial support for our hypothesis. While our hypothesized effect was confirmed, respectful leadership seems to be generally effective for female leaders irrespective of follower gender, thus lending greater support in this context to the arguments of role congruity rather than gender dissimilarity

Clinical Characteristics, Racial Inequities, and Outcomes in Patients with Breast Cancer and COVID-19: A COVID-19 and Cancer Consortium (CCC19) Cohort Study

BACKGROUND: Limited information is available for patients with breast cancer (BC) and coronavirus disease 2019 (COVID-19), especially among underrepresented racial/ethnic populations. METHODS: This is a COVID-19 and Cancer Consortium (CCC19) registry-based retrospective cohort study of females with active or history of BC and laboratory-confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection diagnosed between March 2020 and June 2021 in the US. Primary outcome was COVID-19 severity measured on a five-level ordinal scale, including none of the following complications, hospitalization, intensive care unit admission, mechanical ventilation, and all-cause mortality. Multivariable ordinal logistic regression model identified characteristics associated with COVID-19 severity. RESULTS: 1383 female patient records with BC and COVID-19 were included in the analysis, the median age was 61 years, and median follow-up was 90 days. Multivariable analysis revealed higher odds of COVID-19 severity for older age (aOR per decade, 1.48 [95% CI, 1.32-1.67]); Black patients (aOR 1.74; 95 CI 1.24-2.45), Asian Americans and Pacific Islander patients (aOR 3.40; 95 CI 1.70-6.79) and Other (aOR 2.97; 95 CI 1.71-5.17) racial/ethnic groups; worse ECOG performance status (ECOG PS ≥2: aOR, 7.78 [95% CI, 4.83-12.5]); pre-existing cardiovascular (aOR, 2.26 [95% CI, 1.63-3.15])/pulmonary comorbidities (aOR, 1.65 [95% CI, 1.20-2.29]); diabetes mellitus (aOR, 2.25 [95% CI, 1.66-3.04]); and active and progressing cancer (aOR, 12.5 [95% CI, 6.89-22.6]). Hispanic ethnicity, timing, and type of anti-cancer therapy modalities were not significantly associated with worse COVID-19 outcomes. The total all-cause mortality and hospitalization rate for the entire cohort was 9% and 37%, respectively however, it varied according to the BC disease status. CONCLUSIONS: Using one of the largest registries on cancer and COVID-19, we identified patient and BC-related factors associated with worse COVID-19 outcomes. After adjusting for baseline characteristics, underrepresented racial/ethnic patients experienced worse outcomes compared to non-Hispanic White patients. FUNDING: This study was partly supported by National Cancer Institute grant number P30 CA068485 to Tianyi Sun, Sanjay Mishra, Benjamin French, Jeremy L Warner; P30-CA046592 to Christopher R Friese; P30 CA023100 for Rana R McKay; P30-CA054174 for Pankil K Shah and Dimpy P Shah; KL2 TR002646 for Pankil Shah and the American Cancer Society and Hope Foundation for Cancer Research (MRSG-16-152-01-CCE) and P30-CA054174 for Dimpy P Shah. REDCap is developed and supported by Vanderbilt Institute for Clinical and Translational Research grant support (UL1 TR000445 from NCATS/NIH). The funding sources had no role in the writing of the manuscript or the decision to submit it for publication. CLINICAL TRIAL NUMBER: CCC19 registry is registered on ClinicalTrials.gov, NCT04354701

Presenilin-1 protein expression in familial and sporadic Alzheimer\u27s disease

Mutations of the presenilin PS1 and PS2 genes are closely linked to aggressive forms of early-onset (\u3c60 years) familial Alzheimer\u27s disease. A highly specific monoclonal antibody was developed to identify and characterize the native PS1 protein. Western blot analyses revealed a predominant 32-kd immunoreactive polypeptide in a variety of samples, including PC12 cells transfected with human PS1 complementary DNA, brain biopsy specimens from demented patients, and postmortem samples of frontal neocortex from early-onset familial Alzheimer\u27s disease cases (PS1 and PS2), late-onset sporadic Alzheimer\u27s disease cases, and cases of other degenerative disorders. This truncated polypeptide contains the N-terminus of PS1 and appeared unchanged across cases. In 2 early-onset cases linked to missense mutations in the PS1 gene, a PS1 immunoreactive protein (~49 kd) accumulated in the frontal cortex. This protein was similar in size to full- length PS1 protein present in transfected cells overexpressing PS1 complementary DNA, and in lymphocytes from an affected individual with a deletion of exon 9 of the PS1 gene, suggesting that mutations of the PS1 gene perturb the endoproteolytic processing of the protein. Immunohistochemical studies of control brains revealed that PS1 is expressed primarily in neurons, with the protein localized in the soma and dendritic processes. In contrast, PS1 showed striking localization to the neuropathology in early- onset familial Alzheimer\u27s disease and sporadic Alzheimer\u27s disease cases. PS1 immunoreactivity was present in the neuritic component of senile plaques as well as in neurofibrillary tangles. Localization of PS1 immunoreactivity in familial and sporadic Alzheimer\u27s disease suggests that genetically heterogeneous forms of the disease share a common pathophysiology involving PS1 protein

Legacies of radicalism: China's cultural revolution and the democracy movement of 1989

Students in 1989 were at pains to distinguish their actions from those taken by students in the Cultural Revolution. Yet there were important similarities. In the present paper, we identify influence on the Democracy Movement from the Cultural Revolution through (1) the expansion and/or widespread familiarization of repertories of collective action available to Chinese activists; (2) precedents for collective action that may have lowered the barriers to action for some while raising them for others; (3) the participation of people at different stages of their lives in both movements; (4) the transformation of the significance of the ideas of democracy and political authority wrought by the Cultural Revolution for many Chinese; (5) the impact of the Cultural Revolution on Chinese intellectuals; (6) the material consequences of the Cultural Revolution which contributed to China's position in the post-Mao era and the specific issues reform and protest sought to confront; (7) the discourse of corruption which provided the 1989 movement with its strongest links between students and ordinary citizens, and which was accentuated in the Cultural Revolution; (8) the affirmation of the value of ordinary life by which students in the 1980s, encouraged by the `literature of the wounded', rebelled against the Puritanism and denigration of `unauthorized' personal relationships that had been characteristic of the Cultural Revolution; (9) the role of the Cultural Revolution as a cautionary tale, shaping the movement itself, inhibiting some older intellectuals from participating, and determining much of how the government viewed and responded to the Democracy Movement; and (10) the embeddedness in different ways of both Cultural Revolution and 1989 protests in an international context