The Development of CERVIS: Cervical cancer Early Response Visual Identification System

The goal of CERVIS is to make a substantial, positive impact in the cervical cancer diagnostic space through the development of a minimally invasive, cost effective solution that enables women in low-resource settings to test for cervical cancer on a frugal and effective platform. In the developed world, there are a variety of options that can aid in early detection, including pap smears. However, due to the high cost and laboratory requirements that accompany this procedure, women in low-resource settings rarely have access to this preventative care or regular screenings for cervical cancer. Using new research about the changes in the vaginal microbiome, we aim to create a frugal, visual diagnostic screening tool for early stage cervical cancer as an alternative to the existing expensive, invasive, and clinic-dependent methods. Outcomes will be measured by partnering with a Kenyan NGO to collect data from several clinics

The Grizzly, February 16, 1998

Clark Speaks at Unity House • History Candidate Gives Lecture • African Cultural Exhibit Displayed • Thompson Lectures at Unity House • Pilgrim Resigns After Over Two Decades • Opinion: Sex Scandal Continues; Ursinus Greek Life Equals Ursinus Social Life • Is the Bookstore a Rip Off? • Pearl Jam Yields • Bears Fall Short of Third Title • Ursinus Swimmers Gear Up for Championships • Mullan Hopeful for National Bid • Ursinus Women Moving Their Way to the Centennial Conference Playoffs • Cornish Honored • The Women\u27s Gymnastics Team Peaks Despite a Competitive Losshttps://digitalcommons.ursinus.edu/grizzlynews/1414/thumbnail.jp

The Grizzly, February 9, 1999

Asper Notches 100th Win • Grand Opening for New Bookstore • Faculty Vote to Require Independent Learning Experience • Middle States Grades Ursinus • Spanish Department: Smaller Staff + Higher Enrollment = Big Headaches • Community Service Making a Difference at Ursinus • Opinion: Overcoming Immaturity the Key to Ending Permit Theft; Reader Response; U.S. Sells Out Integrity for Intelligence in Iraq; Free Will an Important Responsibility; Why Gephardt Will Settle for Speaker • The Classical Critic: Bravo Pindell! • Swimming Falls to Swarthmore • Gymnastics Edged by Courtland • Women\u27s Basketball Still in Playoff Hunt • Men\u27s Basketball First in Conference • Ursinus Wrestling Takes Muhlenberg and Gettysburg to the Mathttps://digitalcommons.ursinus.edu/grizzlynews/1433/thumbnail.jp

Transcriptional Analysis of Distant Signaling Induced by Insect Elicitors and Mechanical Wounding in Zea mays

When plants are under insect herbivore attack defensive measures are activated not only locally, but also in distant and systemic tissues. While insect elicitors (IE) abundant in the oral secretions of the attacking herbivore are essential in the regulation of induced defenses, little is known about their effects on systemic defense signaling in maize (Zea mays). The goal of this study was therefore to identify genetic markers that can be used to further characterize local and systemic signaling events induced by IE or mechanical wounding (MW). We selected genes for this study based on their putative involvement in signaling (allene oxide synthase), regulation of gene expression (transcription factor MYC7), and in direct defenses (ribosome inactivating protein) and analyzed their expression in different sections of the treated leaf as well as in systemic parts of the same plant. We found the most significant transcript accumulation of the selected genes after treatment with insect elicitors in those parts with increased JA levels. Additionally, treatment with IE did also induce the accumulation of MYC7 transcripts in basal parts of the treated leaf and systemically. MW, in contrast, did induce RIP and AOS only locally, but not MYC7. This local suppression of MYC7 was further studied by adding glutathione (GSH) as an electron donor to MW plants to quench putative α, β-unsaturated carbonyls, which build up to significant levels around the damage site. Indeed, GSH-treated MW plants accumulated MYC7 at the damage site and also produced more volatiles, suggesting a putative redox-regulatory element being involved in the suppression of MYC7. The results presented herein provide evidence for the specific induction of distant signaling events triggered by IE, most likely through electric signaling. Additionally, a putative role for MW-induced α, β-unsaturated carbonyls in the transcriptional regulation of defense genes was discovered