Utilizing External Services and Sharing Content in a Content Management System

People are using more and more online services. Many of the services are used for storing content. Also the number of users’ personal devices – mobile phones, laptops, cameras, and so forth – is increasing rapidly. Consequently, the amount of content stored in the services and devices people are using is constantly growing. Managing all of the content located in different places is therefore becoming an increasing problem. It is not easy to search for a certain piece of content, if one cannot remember in what service or device the content is stored at. Content can also easily become forgotten and lost in a rarely used device. This thesis presents new and improved features to an existing content management system named VisualREST, which is designed for managing content from all of the user’s devices. We are presenting new ways of importing content from user’s devices, as well as importing content from external services, in order for the content management system to be as comprehensive as possible. Searching content is an important and often used feature of a content management system. Therefore, a new, user-friendlier interface for searching content is presented. Sharing content with other users should be quick and easy, and for that end a notion of context is presented. It is designed to help share content between a predefined group of people. All of these features have been implemented and tested in VisualREST. /Kir1

Unusual Gram-negative bacteria cause more severe bacterial meningitis than the three classical agents in children

Aim To compare the characteristics, mortality and sequelae at hospital discharge of childhood bacterial meningitis (BM) caused by the three "classical" agents Neisseria meningitidis, Haemophilus influenzae or Streptococcus pneumoniae versus BM due to other aetiology in Finland, Latin America and Angola. Methods This observational study is a secondary analysis of data from five prospective treatment trials on non-neonatal BM in Finland, Latin America and Angola in 1984-2017. Results Of the 1568 cases, 1459 (93%) were caused by the classics, 80 (5%) by other Gram-negative and 29 (2%) by other Gram-positive bacteria. Nonclassical Gram-negative disease was encountered especially in Angola (p < 0.0001). Overall, children in the nonclassical group presented later for treatment and were more often underweight and anaemic (p < 0.001). In multivariate analysis, even if the area was strongest predictor of poor outcome, nonclassical Gram-negative BM increased the odds for death twofold and the odds for death or severe sequelae 2.5-fold. Conclusion BM of a nonclassical aetiology is a particularly severe disease affecting especially Angolan children poorly armoured to fight infections. Since vaccinations are diminishing the role of classical agents, that of nonclassical agents is growing.Peer reviewe

Importance of underweight in childhood bacterial meningitis in Finland, Latin America and Angola

Our objective was to explore the importance of underweight on the course of childhood bacterial meningitis (BM) at different study sites, because prior studies showed discrepant results. Using directly comparable, prospective data from three continents, weight-for-age z-scores (WAZ) were determined by WHO Anthro programs in children with BM in Finland (N = 318), LatAm (N = 580), and Angola (N = 780) and compared with data describing the admission, course, and outcome of BM. WAZ < -1 indicates underweight; either mild (< -1 to -2), moderate (< -2 to -3), or severe (< -3). The mean WAZ (SD) was 0.17 (1.17), -0.42 (1.53), and -1.36 (1.44), and the prevalence of moderate-severe underweight 2.8%, 12.6%, and 31.3%, in Finland, LatAm, and Angola, respectively. In univariate analysis, LatAm and Angola showed an association between lower WAZ and poorer condition on admission, slower recovery, and more deaths. In Finland, infrequent underweight limited meaningful analysis. In multivariate analysis of different variables for increasing the odds of death, severe underweight had lower odds compared to disease severity in Angola, but highest in LatAm. Thus, the apparent discrepancy in underweights ' importance for increasing deaths varied from primary to more secondary according to locally more prominent risks.Peer reviewe

Ex tergo audietur - perästä kuuluu

Teema : mielihyvä ja mielipah

Prevalence and significance of anaemia in childhood bacterial meningitis : a secondary analysis of prospectively collected data from clinical trials in Finland, Latin America and Angola

Objectives To describe the prevalence and severity of anaemia and to examine its associations with outcome in children with bacterial meningitis (BM). Design Secondary analysis of descriptive data from five randomised BM treatment trials. Setting Hospitals in Finland, Latin America and Angola. Participants Consecutive children from 2 months to 15 years of age admitted with BM and who had haemoglobin (Hb) measured on admission. Outcome measures Prevalence and degree of anaemia using the WHO criteria, and their associations with recovery with sequelae or death. Results The median Hb was 11.8 g/dL in Finland (N=341), 9.2 g/dL in Latin America (N=597) and 7.6 g/dL in Angola (N=1085). Of the children, 79% had anaemia, which was severe in 29%, moderate in 58% and mild in 13% of cases. Besides study area, having anaemia was independently associated with age 3 days, weight-for-age z-score Conclusion Anaemia, mostly moderate, was common in children with BM, especially in Angola, in underweight children, among those with treatment delay, and in pneumococcal meningitis. Poor outcome was associated with anaemia in all three continents.Peer reviewe

Bacterial Meningitis in Children With Sickle Cell Disease in Angola

Publisher Copyright: Copyright © 2022 The Author(s).Sickle cell disease (SCD) was found in 10% of children with bacterial meningitis (BM) in Luanda, 5-fold more than in the general population. BM children with SCD versus BM children without SCD had higher inflammatory markers, more often had pneumococcal meningitis (71% vs. 39%), and either died (39% vs. 22%) or had a longer hospital stay (15 vs. 11 days).Peer reviewe

Antibiotics by bolus or infusion for bacterial meningitis? : [Authors’ reply]

Non peer reviewe