254 research outputs found

    Spin configurations in Co2FeAl0.4Si0.6 Heusler alloy thin film elements

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    We determine experimentally the spin structure of half-metallic Co2FeAl0.4Si0.6 Heusler alloy elements using magnetic microscopy. Following magnetic saturation, the dominant magnetic states consist of quasi-uniform configurations, where a strong influence from the magnetocrystalline anisotropy is visible. Heating experiments show the stability of the spin configuration of domain walls in confined geometries up to 800 K. The switching temperature for the transition from transverse to vortex walls in ring elements is found to increase with ring width, an effect attributed to structural changes and consequent changes in magnetic anisotropy, which start to occur in the narrower elements at lower temperatures.Comment: 4 pages, 4 figure

    Strain-dependent magnetic configurations in manganite-titanate heterostructures probed with soft X-ray techniques

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    We present a detailed study on the strain-induced magnetic domain structure of a (La,Sr)MnO3 thin film epitaxially grown on a BaTiO3 substrate through the use of polarization-dependent X-ray photoemission electron microscopy and X-ray absorption spectroscopy. Angular-dependent measurements allow us to detect vector magnetization on a single-domain scale, and we relate the strain-induced changes in magnetic anisotropy of the ferromagnetic film to the ferroelectric domain structure of the underlying substrate using X-ray magnetic circular and linear dichroism spectro-microscopy. Comparisons to measurements on a nearly strain free film of (La,Sr)MnO3 grown on a (La,Sr)(Al,Ta)O3 substrate illustrate that the BaTiO3 ferroelectric domain structure imprints specific domain sizes and wall orientations in the (La,Sr)MnO3/BaTiO3 artificial multiferroic heterostructure. Furthermore, a change of the BaTiO3 ferroelectric domain structure either with temperature or with applied electric field results in a corresponding change in the (La,Sr)MnO3 ferromagnetic domain structure, thus showing a possible route to obtain room-temperature electric field control of magnetic anisotropy at the nanoscal

    Motor Extinction in Distinct Reference Frames: A Double Dissociation

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    Objective: Test the hypothesis that right hemisphere stroke can cause extinction of left hand movements or movements of either hand held in left space, when both are used simultaneously, possibly depending on lesion site. Methods: 93 non-hemiplegic patients with acute right hemisphere stroke were tested for motor extinction by pressing a counter rapidly for one minute with the right hand, left hand, or both simultaneously with their hands held at their sides, or crossed over midline. Results: We identified two distinct types of motor extinction in separate patients; 20 patients extinguished left hand movements held in left or right space (left canonical body extinction); the most significantly associated voxel cluster of ischemic tissue was in the right temporal white matter. Seven patients extinguished either hand held in left space (left space extinction), and the most significantly associated voxel cluster of ischemic tissue was in right parietal white matter. Conclusions: There was a double dissociation between left canonical body extinction and left space motor extinction. Left canonical body extinction seems to be associated with more dorsal (parietal) ischemia, and left canonical body extinction seems to be associated with more ventral (temporal) ischemia

    Strain-dependent magnetic configurations in manganite-titanate heterostructures probed with soft X-ray techniques

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    We present a detailed study on the strain-induced magnetic domain structure of a (La,Sr)MnO3 thin film epitaxially grown on a BaTiO3 substrate through the use of polarization-dependent X-ray photoemission electron microscopy and X-ray absorption spectroscopy. Angular-dependent measurements allow us to detect vector magnetization on a single-domain scale, and we relate the strain-induced changes in magnetic anisotropy of the ferromagnetic film to the ferroelectric domain structure of the underlying substrate using X-ray magnetic circular and linear dichroism spectro-microscopy. Comparisons to measurements on a nearly strain free film of (La,Sr)MnO3 grown on a (La,Sr)(Al,Ta)O-3 substrate illustrate that the BaTiO3 ferroelectric domain structure imprints specific domain sizes and wall orientations in the (La,Sr)MnO3/BaTiO3 artificial multiferroic heterostructure. Furthermore, a change of the BaTiO3 ferroelectric domain structure either with temperature or with applied electric field results in a corresponding change in the (La,Sr)MnO3 ferromagnetic domain structure, thus showing a possible route to obtain room-temperature electric field control of magnetic anisotropy at the nanoscale

    Meta-Analysis of Mass Balances Examining Chemical Fate during Wastewater Treatment

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    Mass balances are an instructive means for investigating the fate of chemicals during wastewater treatment. In addition to the aqueous-phase removal efficiency (Φ), they can inform on chemical partitioning, transformation, and persistence, as well as on the chemical loading to streams and soils receiving, respectively, treated effluent and digested sewage sludge (biosolids). Release rates computed on a per-capita basis can serve to extrapolate findings to a larger scale. This review examines over a dozen mass balances conducted for various organic wastewater contaminants, including prescription drugs, estrogens, fragrances, antimicrobials, and surfactants of differing sorption potential (hydrophobicity), here expressed as the 1-octanol−water partition coefficient (KOW) and the organic carbon normalized sorption coefficient (KOC). Major challenges to mass balances are the collection of representative samples and accurate quantification of chemicals in sludge. A meta-analysis of peer-reviewed data identified sorption potential as the principal determinant governing chemical persistence in biosolids. Occurrence data for organic wastewater compounds detected in digested sludge followed a simple nonlinear model that required only KOW or KOC as the input and yielded a correlation coefficient of 0.9 in both instances. The model predicted persistence in biosolids for the majority (>50%) of the input load of organic wastewater compounds featuring a log10KOW value of greater than 5.2 (log10KOC > 4.4). In contrast, hydrophobicity had no or only limited value for estimating, respectively, Φ and the overall persistence of a chemical during conventional wastewater treatment

    The yeast P5 type ATPase, Spf1, regulates manganese transport into the endoplasmic reticulum

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    The endoplasmic reticulum (ER) is a large, multifunctional and essential organelle. Despite intense research, the function of more than a third of ER proteins remains unknown even in the well-studied model organism Saccharomyces cerevisiae. One such protein is Spf1, which is a highly conserved, ER localized, putative P-type ATPase. Deletion of SPF1 causes a wide variety of phenotypes including severe ER stress suggesting that this protein is essential for the normal function of the ER. The closest homologue of Spf1 is the vacuolar P-type ATPase Ypk9 that influences Mn2+ homeostasis. However in vitro reconstitution assays with Spf1 have not yielded insight into its transport specificity. Here we took an in vivo approach to detect the direct and indirect effects of deleting SPF1. We found a specific reduction in the luminal concentration of Mn2+ in ∆spf1 cells and an increase following it’s overexpression. In agreement with the observed loss of luminal Mn2+ we could observe concurrent reduction in many Mn2+-related process in the ER lumen. Conversely, cytosolic Mn2+-dependent processes were increased. Together, these data support a role for Spf1p in Mn2+ transport in the cell. We also demonstrate that the human sequence homologue, ATP13A1, is a functionally conserved orthologue. Since ATP13A1 is highly expressed in developing neuronal tissues and in the brain, this should help in the study of Mn2+-dependent neurological disorders

    Magnetoelectroelastic control of magnetism in an artificial multiferroic

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    We study the coexistence of strain-and charge-mediated magnetoelectric coupling in a cobalt (0-7 nm) wedge on ferroelectric (011)-oriented [Pb(Mg-1/3/Nb-2/3)O-3](0.68)-[PbTiO3](0.32) using surface-sensitive x-ray magnetic circular dichroism spectroscopy at the Co L-3,L-2 edges. Three distinct electric field driven remanent magnetization states can be set in the Co film at room temperature. Ab initio density functional theory calculations unravel the relative contributions of both strain and charge to the observed magnetic anisotropy changes illustrating magnetoelectroelastic coupling at artificial multiferroic interfaces

    Uptake, Translocation, and Accumulation of Pharmaceutical and Hormone Contaminants in Vegetables

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    A team led by Wei Zheng, senior research scientist at ISTC, investigated whether our food is at risk of accumulating PPCPs when irrigated with wastewater from concentrated animal feedlot operations (CAFOs) and wastewater treatment plants (WWTPs). The results appeared in Zheng, Wei et al (2014). "Uptake, Translocation, and Accumulation of Pharmaceutical and Hormone Contaminants in Vegetables." in Kyung Myung, Norbert M. Satchivi, and Colleen K. Kingston, eds. Retention, Uptake, and Translocation of Agrochemicals in Plants. Washington, DC : American Chemical Society, 167-181. DOI: 10.1021/bk-2014-1171.ch009.Ope

    Triclocarban Mediates Induction of Xenobiotic Metabolism through Activation of the Constitutive Androstane Receptor and the Estrogen Receptor Alpha

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    Triclocarban (3,4,4′-trichlorocarbanilide, TCC) is used as a broad-based antimicrobial agent that is commonly added to personal hygiene products. Because of its extensive use in the health care industry and resistance to degradation in sewage treatment processes, TCC has become a significant waste product that is found in numerous environmental compartments where humans and wildlife can be exposed. While TCC has been linked to a range of health and environmental effects, few studies have been conducted linking exposure to TCC and induction of xenobiotic metabolism through regulation by environmental sensors such as the nuclear xenobiotic receptors (XenoRs). To identify the ability of TCC to activate xenobiotic sensors, we monitored XenoR activities in response to TCC treatment using luciferase-based reporter assays. Among the XenoRs in the reporter screening assay, TCC promotes both constitutive androstane receptor (CAR) and estrogen receptor alpha (ERα) activities. TCC treatment to hUGT1 mice resulted in induction of the UGT1A genes in liver. This induction was dependent upon the constitutive active/androstane receptor (CAR) because no induction occurred in hUGT1Car−/− mice. Induction of the UGT1A genes by TCC corresponded with induction of Cyp2b10, another CAR target gene. TCC was demonstrated to be a phenobarbital-like activator of CAR in receptor-based assays. While it has been suggested that TCC be classified as an endocrine disruptor, it activates ERα leading to induction of Cyp1b1 in female ovaries as well as in promoter activity. Activation of ERα by TCC in receptor-based assays also promotes induction of human CYP2B6. These observations demonstrate that TCC activates nuclear xenobiotic receptors CAR and ERα both in vivo and in vitro and might have the potential to alter normal physiological homeostasis. Activation of these xenobiotic-sensing receptors amplifies gene expression profiles that might represent a mechanistic base for potential human health effects from exposure to TCC
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