First Perihelion of EUI on the Solar Orbiter mission

Context. The Extreme Ultraviolet Imager (EUI), onboard Solar Orbiter consists of three telescopes: the two High Resolution Imagers in EUV (HRIEUV) and in Lyman-{\alpha} (HRILya), and the Full Sun Imager (FSI). Solar Orbiter/EUI started its Nominal Mission Phase on 2021 November 27. Aims. EUI images from the largest scales in the extended corona off limb, down to the smallest features at the base of the corona and chromosphere. EUI is therefore a key instrument for the connection science that is at the heart of the Solar Orbiter mission science goals. Methods. The highest resolution on the Sun is achieved when Solar Orbiter passes through the perihelion part of its orbit. On 2022 March 26, Solar Orbiter reached for the first time a distance to the Sun close to 0.3 au. No other coronal EUV imager has been this close to the Sun. Results. We review the EUI data sets obtained during the period 2022 March-April, when Solar Orbiter quickly moved from alignment with the Earth (2022 March 6), to perihelion (2022 March 26), to quadrature with the Earth (2022 March 29). We highlight the first observational results in these unique data sets and we report on the in-flight instrument performance. Conclusions. EUI has obtained the highest resolution images ever of the solar corona in the quiet Sun and polar coronal holes. Several active regions were imaged at unprecedented cadences and sequence durations. We identify in this paper a broad range of features that require deeper studies. Both FSI and HRIEUV operate at design specifications but HRILya suffered from performance issues near perihelion. We conclude emphasising the EUI open data policy and encouraging further detailed analysis of the events highlighted in this paper

Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

BACKGROUND: The diagnostic and pathophysiological relevance of antibodies to aquaporin-4 (AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been intensively studied. However, little is known so far about the clinical impact of AQP4-Ab seropositivity. OBJECTIVE: To analyse systematically the clinical and paraclinical features associated with NMO spectrum disorders in Caucasians in a stratified fashion according to the patients' AQP4-Ab serostatus. METHODS: Retrospective study of 175 Caucasian patients (AQP4-Ab positive in 78.3%). RESULTS: Seropositive patients were found to be predominantly female (p 1 myelitis attacks in the first year were identified as possible predictors of a worse outcome. CONCLUSION: This study provides an overview of the clinical and paraclinical features of NMOSD in Caucasians and demonstrates a number of distinct disease characteristics in seropositive and seronegative patients

Evaluation of Potentially Predictive Markers for Anti-Angiogenic Therapy with Sunitinib in Recurrent Ovarian Cancer Patients

AbstractINTRODUCTION: In ovarian cancer, new therapeutic strategies are needed because the vast majority of patients develop a recurrence and resistance to platinum derivates. Attached to the AGO-OVAR2.11 study investigating the multityrosine kinase inhibitor sunitinib in recurrent platinum refractory ovarian cancers, this translational research project assesses the potential value of serum vascular endothelial growth factor (VEGF), soluble VEGF receptor-3 (sVEGFR-3), and angiopoietin-2 (Ang-2) levels for progression-free survival (PFS). MATERIALS AND METHODS: Longitudinal serum samples were taken while the patient was on study drugs. Serum concentration of VEGF, sVEGFR-3, and Ang-2 was determined by ELISA. The slope of the markers was correlated to the PFS. RESULTS: Patients showing a decrease in VEGF concentration had a median PFS of 10.5 months [confidence interval (CI), 2.89–12.25] compared to 2.9 months (CI, 1.48–5.32) in the case of an increase (P = .17). The stratified log-rank test showed a trend for longer PFS if a decrease of Ang-2 was observed (P = .089). Dichotomized in absolute decrease or increase, the PFS was 8.4 months (CI, 2.89–12.26) versus 2.7 months (CI, 1.05–5.32), respectively. Patients with a reduction of the sVEGFR-3 concentration had a median PFS of 4.76 months (CI 2.86–10.65) versus 8.61 months (CI, 1.05-not estimable) in patients with an increase of sVEGFR-3. This observation was statistically not significant in the log-rank test (P = .81). CONCLUSION: Ang-2 could potentially identify a patient population that might have a better PFS when under anti-angiogenic treatment, like the tyrosine kinase inhibitor sunitinib

The Extreme UV Imager of Solar Orbiter – From detailed design to Flight Model

The Extreme Ultraviolet Imager (EUI) on-board the Solar Orbiter mission will provide full-sun and high-resolution image sequences of the solar atmosphere at selected spectral emission lines in the extreme and vacuum ultraviolet. After the breadboarding and prototyping activities that focused on key technologies, the EUI project has completed the design phase and has started the final manufacturing of the instrument and its validation. The EUI instrument has successfully passed its Critical Design Review (CDR). The process validated the detailed design of the Optical Bench unit and of its sub-units (entrance baffles, doors, mirrors, camera, and filter wheel mechanisms), and of the Electronic Box unit. In the same timeframe, the Structural and Thermal Model (STM) test campaign of the two units have been achieved, and allowed to correlate the associated mathematical models. The lessons learned from STM and the detailed design served as input to release the manufacturing of the Qualification Model (QM) and of the Flight Model (FM). The QM will serve to qualify the instrument units and sub-units, in advance of the FM acceptance tests and final on-ground calibration

Challenges during Metis-Solar Orbiter commissioning phase

Metis is the visible light and UV light imaging coronagraph on board the ESA-NASA mission Solar Orbiter that has been launched February 10th, 2020, from Cape Canaveral. Scope of the mission is to study the Sun up close, taking high-resolution images of the Sun’s poles for the first time, and understanding the Sun-Earth connection. Metis coronagraph will image the solar corona in the linearly polarized broadband visible radiation and in the UV HI Ly-α line from 1.6 to 3 solar radii when at Solar Orbiter perihelion, providing a diagnostics, with unprecedented temporal coverage and spatial resolution, of the structures and dynamics of the full corona. Solar Orbiter commissioning phase big challenge was Covid-19 social distancing phase that affected the way commissioning of a spacecraft and its payload is typically done. Metis coronagraph on-board Solar Orbiter had its additional challenges: to wake up and check the performance of the optical, electrical and thermal subsystems, most of them unchecked since Metis delivery to spacecraft prime, Airbus, in May 2017. The roadmap to the fully commissioned coronagraph is here described throughout the steps from the software functional test, the switch on of the detectors of the two channels, UV and visible, to the optimization of the occulting system and the characterization of the instrumental stray light, one of the most challenging features in a coronagraph

In-flight optical performance assessment for the Metis solar coronagraph

Metis is a multi-wavelength coronagraph onboard the European Space Agency (ESA) Solar Orbiter mission. The instrument features an innovative instrument design conceived for simultaneously imaging the Sun's corona in the visible and ultraviolet range. The Metis visible channel employs broad-band, polarized imaging of the visible K-corona, while the UV one uses narrow-band imaging at the HI Lya, i.e. 121.6 nm. During the commissioning different acquisitions and activities, performed with both the Metis channels, have been carried out with the aim to check the functioning and the performance of the instrument. In particular, specific observations of stars have been devised to assess the optical alignment of the telescope and to derive the instrument optical parameters such as focal length, PSF and possibly check the optical distortion and the vignetting function. In this paper, the preliminary results obtained for the PSF of both channels and the determination of the scale for the visible channel will be described and discussed. The in-flight obtained data will be compared to those obtained on-ground during the calibration campaign

First perihelion of EUI on the Solar Orbiter mission

International audienceContext. The Extreme Ultraviolet Imager (EUI) on board Solar Orbiter consists of three telescopes: the two High Resolution Imagers, in EUV (HRIEUV) and in Lyman-α (HRILya), and the Full Sun Imager (FSI). Solar Orbiter/EUI started its Nominal Mission Phase on 2021 November 27. Aims. Our aim is to present the EUI images from the largest scales in the extended corona off-limb down to the smallest features at the base of the corona and chromosphere. EUI is therefore a key instrument for the connection science that is at the heart of the Solar Orbiter mission science goals. Methods. The highest resolution on the Sun is achieved when Solar Orbiter passes through the perihelion part of its orbit. On 2022 March 26, Solar Orbiter reached, for the first time, a distance to the Sun close to 0.3 au. No other coronal EUV imager has been this close to the Sun. Results. We review the EUI data sets obtained during the period 2022 March- April, when Solar Orbiter quickly moved from alignment with the Earth (2022 March 6), to perihelion (2022 March 26), to quadrature with the Earth (2022 March 29). We highlight the first observational results in these unique data sets and we report on the in-flight instrument performance. Conclusions. EUI has obtained the highest resolution images ever of the solar corona in the quiet Sun and polar coronal holes. Several active regions were imaged at unprecedented cadences and sequence durations. We identify in this paper a broad range of features that require deeper studies. Both FSI and HRIEUV operated at design specifications, but HRILya suffered from performance issues near perihelion. We conclude by emphasizing the EUI open data policy and encouraging further detailed analysis of the events highlighted in this paper

Metis: the Solar Orbiter visible light and ultraviolet coronal imager

Aims. Metis is the first solar coronagraph designed for a space mission and is capable of performing simultaneous imaging of the off-limb solar corona in both visible and UV light. The observations obtained with Metis aboard the Solar Orbiter ESA-NASA observatory will enable us to diagnose, with unprecedented temporal coverage and spatial resolution, the structures and dynamics of the full corona in a square field of view (FoV) of ±2.9° in width, with an inner circular FoV at 1.6°, thus spanning the solar atmosphere from 1.7 R⊙ to about 9 R⊙, owing to the eccentricity of the spacecraft orbit. Due to the uniqueness of the Solar Orbiter mission profile, Metis will be able to observe the solar corona from a close (0.28 AU, at the closest perihelion) vantage point, achieving increasing out-of-ecliptic views with the increase of the orbit inclination over time. Moreover, observations near perihelion, during the phase of lower rotational velocity of the solar surface relative to the spacecraft, allow longer-term studies of the off-limb coronal features, thus finally disentangling their intrinsic evolution from effects due to solar rotation. Methods. Thanks to a novel occultation design and a combination of a UV interference coating of the mirrors and a spectral bandpass filter, Metis images the solar corona simultaneously in the visible light band, between 580 and 640 nm, and in the UV H