Fibro-Epithelial Polyp: Case Report with Literature Review

Oral fibroma is the most common benign soft tissue tumor caused due to continuous trauma from sharp cusp of teeth or faulty dental restoration. It presents as sessile or occasionally pedunculated painless swelling which can be soft to firm in consistency. Its incidence occurs mostly during third to fifth decade and shows preference for female. Its occurrence corresponds with intraoral areas that are prone to trauma such as the tongue, buccal mucosa and labial mucosa, lip, gingiva. Even with conservative surgical excision, the lesion may recur until the source of continuous irritation persists. This article presents a case of large size oral fibroma on left alveolar region associated with ulceration along with literature review

MicroRNAs as Future Treatment Tools and Diagnostic Biomarkers in Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder and is considered to be the most common form of dementia. This disorder is characterized by the formation of amyloid β (Aβ) plaques, neurofibrillary tangles, and alterations in synaptic function, all of which cause memory loss and behavioral disturbances. Despite the high prevalence of AD, effective therapeutic and diagnostic tools remain unavailable. MicroRNAs (miRNAs, miRs) are regulatory non-coding RNAs that target mRNAs. MiRNAs are involved in the regulation of the expressions of APP and BACE1, Aβ clearance, and the formation of neuro-fibrillary tangles. Furthermore, there are evidences that show alteration in the expression of several miRs in AD. MicroRNA is emerging as a biomarker because they have high specificity and, efficiency, and can be detected in biological fluids such as cerebrospinal fluid, tear, urine, blood. Moreover, miRNAs may be acquired and measured easily by utilizing real-time PCR, next-generation sequencing, or microarray. These techniques are cost-effective in comparison with imaging techniques such as magnetic resonance imaging, positron emission tomography. These features make miRNAs viable therapeutic as well as diagnostic tools in the treatment of AD. This review covers the regulatory function of miRNAs in AD, as well as their prospective applications as diagnostic biomarkers

Assessment of Knowledge and Attitude Towards Hepatitis B Infection Among Health-Care Professionals in A North Indian City

Introduction: Hepatitis B is an infection which occurs frequently worldwide. Hepatitis B virus is a DNA virus and is etiologically related to family Hepadnaviridae.Most of the cases of Hepatitis B virus infection do not have any symptoms when they are newly or chronically infected due to which there is silent spread of the infection which later causes serious liver disease. Incidence of the Hepatitis B virus infection among health-care professionals has been estimated to be 2–4 times more as compared to the general population.Aims: to assess the knowledge and attitude towards Hepatitis B infection among medical, dental, and nursing students in Bareilly city.Settings and Design: A cross-sectional observational study was conducted among the medical and nursing students of Rohilkhand Medical College and Hospital and dental students of Institute of Dental Sciences, Bareilly.Method and Materials: A self-reported questionnaire was distributed among all the students of the study who were present at the day.Statistical analysis used: p-value was calculated using Kruskal Walli’s ANOVA test. A p-value of 0.05 or less was used as cut off level for statistical significance.Results: Total 222 students were selected out of which 60 were medical, 60 were dental and 102 were nursing. In our study medical students had better knowledge, attitude towards Hepatitis B infection than dental and nursing students.Conclusions: None of the students of medical, dental, and nursing were fully aware on all aspects of Hepatitis B Virus infection and the vaccination status was found to be unsatisfactory which increased the risk to acquire Hepatitis B infection

The prevalence of oral mucosal lesions in the patients visiting a dental school in Northern India in relation to sex, site and distribution: A retrospective study.

Objective: To determine the distribution of oro-mucosal lesions in patients of Maharishi Markendeshwer College of Dental Sciences and Research, (MMCDSR), Mullana. Further to identify sex predilection and different sites which are more susceptible to different oro-mucosal lesions. Materials and methods: A hospital based retrospective study was carried out from 1st January 2007 till 31st December 2009 at (MMCDSR), Mullana. A total of 451 biopsy reports were studied. Distribution and prevalence of oro-mucosal lesions among the data were analyzed using SPSS software package version 13. Results: There was no mention of habits in the biopsy reports of 85.4 % (385 patients) of the subjects. Out of the 66 subjects whose habits were mentioned, 71.2 % (47 patients) used to smoke tobacco in one form or the other. 21.2 % (14 patients) used to chew tobacco, 4.5 % (3 patients) of the subjects were in the habit of both smoking and chewing tobacco. More percentage of females 53.1 % were present in the age-group of 11-20 years as compared to males 46.9 % whereas in all other age-groups males were more in number. Regarding the distribution of oral lesions in the oral cavity, buccal mucosa was the common site for the presence of potentially malignant disorders in 16.8 % of the subjects and it was also the most common site for all the lesions. Conclusion: Lesion prevalence differed significantly by age, sex, and tobacco use. Individual demographic details such as age, gender, occupation, food habits, other deleterious oral habits, religion and oral hygiene measures should have a provision in biopsy request sheet and should be duly filled which will help in identifying risk-groups. Community programmes should be taken for public health to get them screened for any oral-mucosal lesions by availing pathological lab facilities

Technological Advances to Address Current Issues in Entomology: 2020 Student Debates

The 2020 Student Debates of the Entomological Society of America (ESA) were live-streamed during the Virtual Annual Meeting to debate current, prominent entomological issues of interest to members. The Student Debates Subcommittee of the National ESA Student Affairs Committee coordinated the student efforts throughout the year and hosted the live event. This year, four unbiased introductory speakers provided background for each debate topic while four multi-university teams were each assigned a debate topic under the theme ‘Technological Advances to Address Current Issues in Entomology’. The two debate topics selected were as follows: 1) What is the best taxonomic approach to identify and classify insects? and 2) What is the best current technology to address the locust swarms worldwide? Unbiased introduction speakers and debate teams began preparing approximately six months before the live event. During the live event, teams shared their critical thinking and practiced communication skills by defending their positions on either taxonomical identification and classification of insects or managing the damaging outbreaks of locusts in crops

Comparison Between Proseal Laryngeal Mask Airway and Supreme Laryngeal Mask Airway in Laparoscopic Cholecystectomy: A Randomized Controlled Trial

Introduction: Supraglottic airway devices (SADs) offer an alternative airway with improved airway seal enable the use of higher airway pressures during positive pressure ventilation (PPV). We compared the safety and efficacy of laryngeal mask airway (LMA) Proseal and LMA Supreme in laparoscopic cholecystectomy. Materials and Methods: Eighty patients, 18-60 years, ASA grade 1 & 2 were randomly allocated into two groups of 40 each. After induction of anesthesia, LMA Supreme or LMA Proseal of appropriate size was then inserted randomly. Parameters like the ease of LMA insertion; ease of OGT insertion; oropharyngeal leak pressure (OLP); hemodynamics; adequacy of ventilation were recorded. Complications, if any, were also recorded. Results: LMA Supreme was easier to insert than LMA Proseal. Gastric tube insertion was comparatively easier in LMA Supreme than LMA Proseal. The mean oropharyngeal leak pressure was higher with LMA Proseal (31.98 ± 2.49cmH2O) than with LMA Supreme (30.23 ± 3.65 cmH2O). Peak airway pressures were comparable for the two groups. There was comparatively more airway trauma (mucosal injury, sore throat) in LMA Proseal than LMA Supreme. Conclusion: A higher oropharyngeal leak pressure makes LMA Proseal a better choice than LMA Supreme in procedures with raised intragastric pressure

Tenofovir induced lichenoid drug eruption

Cutaneous adverse reactions are a common complication of anti-retroviral therapy. Tenofovir is a newer anti-retroviral drug belonging to the nucleotide reverse transcriptase inhibitor group. Systemic adverse effects like nausea, vomiting, diarrhea, hepatotoxicity and renal toxicity are common with tenofovir but cutaneous adverse effects are rare. Lichenoid drug eruptions are a common adverse effect seen with a large variety of drugs including antimalarials, antihypertensives, nonsteroidal anti-inflammatory drugs and diuretics. Lichenoid drug eruption is a rare cutaneous adverse effect of tenofovir with only a single case reported till date. Here, we report a case of tenofovir induced lichenoid drug eruption in a 54-year-old human immunodeficiency virus affected male who presented with generalized lichenoid eruption after 6 weeks of initiation of tenofovir and complete clearance on cessation of the drug

Sorafenib induced acral pigmentation: A new entity

Sorafenib is a multikinase inhibitor commonly used for the treatment of advanced renal cell and hepatocellular carcinoma. The commonly reported dermatological adverse effects of Sorafenib include hand-foot syndrome (HFS), alopecia, pruritus, facial and scalp erythema, splinter hemorrhages, keratoacanthomas, squamous cell carcinomas and eruptive melanocytic naevi. We report a case of asymptomatic hyperpigmentation of the palms and soles in a patient receiving Sorafenib therapy for advanced renal cell carcinoma, in the absence of features of classic HFS, which has not been previously reported in the literature

Incidence and risk factors of emergency peripartum hysterectomy: A cross-sectional study from a single tertiary care maternity hospital

Background: Emergency peripartum hysterectomy (EPH) is a life-saving surgical surgery performed during or after childbirth to preserve the lives of women and newborns in life-threatening conditions. It is linked to high rates of maternal morbidity and mortality. This study aimed to determine the incidence and risk factors for EPH at a tertiary care maternity hospital in Jammu and Kashmir, India. Methods: Between January 2020 and December 2022, retrospective descriptive cohort research was carried out. All pregnant patients scheduled for delivery at the Obstetrics and Gynecology department of SMGS, GMC Jammu, were included in the study. Maternal demographics, medical and obstetric history, EPH indications, surgical and obstetric care, and maternal and newborn outcomes were all gathered from medical records and hospital databases. Descriptive analysis and statistical tests were performed using SPSS Statistics. Results: The study comprised 104 cases of EPH, with an incidence of 2.40/1000 deliveries. The usual maternal age at delivery was 36 years, and the median number of children was two. Previous cesarean delivery was a substantial risk factor, with at least one previous cesarean in 69.2% of cases. The most common cause of EPH, accounting for 73.0% of cases, was aberrant placentation. Less common indicators were uterine atony, uterine rupture, uterine myoma, and placental abruption. Total hysterectomy was performed in 83.3% of cases, with general anesthesia being the predominant type of anesthesia. The median estimated blood loss was 2100 mL, and intraoperative complications were observed in 29.8% of cases. No maternal deaths were reported. Conclusion: In the examined cohort, the incidence of EPH was 2.40/1000 deliveries. Abnormal placentation, including placenta previa and placenta accreta spectrum, as well as previous cesarean birth, were significant risk factors for EPH