Translocation of residual ethoprophos and tricyclazole from soil to spinach

The dissipation of ethoprophos and tricyclazole in soil and their translocation tendency to spinach were investigated. Prior to field trials, the analytical method for the determination of these pesticide residues was optimized and validated on soil and spinach. The field trial was conducted under greenhouse conditions for two different pretreatment periods with the pesticides. After treating with pesticides 30 (PBI-30) and 60 days (PBI-60) before seeding, soil samples were collected on different days for the dissipation study of soil. Spinach samples were harvested from the soil, and 50% and 100% mature spinach samples were collected. The initial amounts of ethoprophos residue in the PBI-60 and PBI-30 soils were 0.21 and 2.74 mg/kg, respectively, and these both decreased to less than 0.01 mg/kg on the day of spinach harvest. Similar initial residues of tricyclazole were observed in the PBI-60 (0.87 mg/kg) and PBI-30 soils (0.84 mg/kg), and these decreased to 0.44 and 0.34 mg/kg, respectively. The half-lives of ethoprophos in the soils were calculated as 7.6 and 4.8 days, respectively, while relatively long half-lives of 36.5 and 77.0 days were calculated for tricyclazole. According to the pesticide residue amounts in the spinach, the translocation rate from the soil to the spinach was determined. In the case of ethoprophos, the residual amount was already rapidly degraded in the soil, and the translocation rate could not be confirmed. On the other hand, for tricyclazole, it was confirmed that 1.19 to 1.61% of the residual amount in soil was transferred to spinach. According to these results, safe management guidelines for tricyclazole in soil were suggested considering the maximum residue limit on spinach.This work was supported by the Rural Development Administration (PJ0152772020)

Time-Resolved in Situ Visualization of the Structural Response of Zeolites During Catalysis

Zeolites are three-dimensional aluminosilicates having unique properties from the size and connectivity of their sub-nanometer pores, the Si/Al ratio of the anionic framework, and the charge-balancing cations. The inhomogeneous distribution of the cations affects their catalytic performances because it influences the intra-crystalline diffusion rates of the reactants and products. However, the structural deformation regarding inhomogeneous active regions during the catalysis is not yet observed by conventional analytical tools. Here we employ in situ X-ray free electron laser-based time-resolved coherent X-ray diffraction imaging to investigate the internal deformations originating from the inhomogeneous Cu ion distributions in Cu-exchanged ZSM-5 zeolite crystals during the deoxygenation of nitrogen oxides with propene. We show that the interactions between the reactants and the active sites lead to an unusual strain distribution, confirmed by density functional theory simulations. These observations provide insights into the role of structural inhomogeneity in zeolites during catalysis and will assist the future design of zeolites for their applications

Acquisition of Second Language Prosody and the Role of Prosody in Discourse: A Study of English Speakers’ Korean and Korean Speakers’ English

This dissertation investigates the acquisition of second language (L2) prosody (e.g.,intonation, stress, rhythm) in native English speakers’ Korean and native Korean speakers’English based on the Autosegmental-Metrical (AM) framework. Specifically, by comparingprosodic characteristics of the first language (L1) and L2, this study examines how L2 speakersnegotiate meanings in discourse (e.g., signal turn-taking and convey various pragmaticmeanings) through intonation and co-occurring grammatical resources, and why the speech of L2speakers sounds foreign. There is a lack of understanding of the role of L2 prosody at thediscourse level. Considerable research focuses on L2 prosody in made-up sentences, failing toexplain meaning negotiation conveyed through prosody. Moreover, few studies have usedappropriate prosodic frameworks when describing prosodic errors of L2 speech.In this dissertation, Korean L2 data were collected from 12 oral proficiency interviews(OPI) between Korean L2 interviewees and a native Korean interviewer; four interviews withnative Korean speakers served as controls. English L2 data were collected from 12 oralproficiency tests designed for international teaching assistants at the University of California,Los Angeles; three presentations by native English speakers served as controls. The data werelabeled using the Korean TOnes and Break Indices (K-ToBI, Jun 1993, 2000, 2005) andMainstream American English (MAE) ToBI (Pierrehumbert, 1980; Beckman & Pierrehumbert,1986; Beckman et al. 2005) transcription systems. Analysis revealed that L2 speakers at differentproficiency levels (i.e., intermediate and advanced) were able to use prosody to signal turncontinuations but more advanced speakers were better at using prosody to convey variouspragmatic meanings appropriate to the conversational context. However, the foreign accents orerror types in prosody were frequent in L2 production at both proficiency levels, suggesting lateracquisition of these features.This study introduces how the AM framework can be used to analyze L2 prosody indiscourse. The study further suggests crosslinguistic similarities in the acquisition order betweenprosody associated with pragmatic meanings and prosody associated with nonpragmaticmeanings

Emphasis on Adipocyte Transformation: Anti-Inflammatory Agents to Prevent the Development of Cancer-Associated Adipocytes

Of the various cell types in the tumor microenvironment (TME), adipocytes undergo a dynamic transformation when activated by neighboring cancer cells. Although these adipocytes, known as cancer-associated adipocytes (CAAs), have been reported to play a crucial role in tumor progression, the factors that mediate their transformation remain elusive. In this review, we discuss the hypothesis that inflammatory signals involving NF-ĸB activation can induce lipolysis and adipocyte dedifferentiation. This provides a mechanistic understanding of CAA formation and introduces the concept of preventing adipocyte transformation via anti-inflammatory agents. Indeed, epidemiological studies indicate a higher efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) in obese patients with cancer, suggesting that NSAIDs can modulate the TME. Inhibition of cyclooxygenase-2 (COX-2) and prostaglandin production leads to the suppression of inflammatory signals such as NF-ĸB. Thus, we suggest the use of NSAIDs in cancer patients with metabolic disorders to prevent the transformation of TME components. Moreover, throughout this review, we attempt to expand our knowledge of CAA transformation to improve the clinical feasibility of targeting CAAs

Establishment of a Geographic Information System-Based Algorithm to Analyze Suitable Locations for Green Roofs and Roadside Trees

Urban green spaces offer various ecosystem services such as those for controlling the urban microclimate, improving water circulation, and providing leisure and recreation opportunities. However, it is almost impossible to create new, large green spaces in cities where urbanization has been long underway. Consequently, small-scale green spaces such as green roofs and roadside trees are gaining attention as features that can increase the effects of ecosystem services. Although the area of individual buildings in urban areas is relatively small, the sum of building rooftop areas account for a large portion of urban areas. Moreover, there are areas widely available throughout cities where street trees could be planted. However, this requires large amounts of accurate databases (DBs) and long-term spatial analyses to identify specific locations suitable for small-scale green facilities on a citywide scale using a geographic information system (GIS). Consequently, in-depth research on this topic has been insufficient. Thus, this study presents an algorithm to analyze locations where green roofs and roadside trees could be introduced based on GIS spatial analysis and verifies the effectiveness of the algorithm built for the city of Seoul. In addition, computational fluid dynamics (CFD) modeling is performed to analyze the temperature reduction effect, the representative function of ecosystem control services that can be brought about by the potential green spaces. The results show that rooftop greening in study areas is possible in 311,793 of 742,770 buildings. The rooftop floor area of buildings that can apply rooftop greening is 33,288,745 m2, which is about 50% of the total area of the rooftop in Seoul. It was found that roadside trees could be planted on a sidewalk with an extension length of 872,725 m and an area of 838,864 m2. A total of 145,366 trees can be planted in the study area. In addition, it was shown that the introduction of green roofs reduced temperatures by 0.13 °C to 0.14 °C and roadside trees reduced temperatures by 0.14 °C to 0.6 °C. With the growing need to improve urban ecosystem services as a result of rapid climate change, the algorithm developed in this study can be utilized to create spatial policies that expand and manage urban green spaces and thereby contribute to the improvement of urban ecosystem services

Optimization of Processor Clock Frequency for Sensor Network Nodes Based on Energy Use and Timing Constraints

The effectiveness of sensor networks depends critically on efficient power management of the sensor nodes. Dynamic voltage frequency scaling (DVFS) and dynamic power management (DPM) have been proposed to enable energy-efficient scheduling for real-time and embedded systems. However, most power-aware scheduling algorithms are designed to deal with only those cases in which the task execution time is determined solely by the clock frequency of the processor. In this study, we propose an extended task execution model that is appropriate for the sensor nodes and an algorithm that determines the optimal clock frequency for a node's processor. We analyze the extended model and verify that our algorithm calculates the clock frequency that optimizes energy savings while satisfying the timing constraints

Magnetic lock-in phase transition in Tb0.95Er0.05Ni5 driven by low magnetic fields

AbstractThe magnetic properties of a mixed inter-metallic compound, Tb0.95Er0.05Ni5, were investigated using a neutron diffraction method at low temperatures. These compounds were known to have a successive magnetic phase transition from the paramagnetic state at high temperature to a lock-in phase at low temperature through intermediate phases, i.e., PM(paramagnetic)–FM(ferromagnetic)–IC(incommensurate)–L(lock-in) in reverse order of temperature. A meta-magnetic phase transition between an IC phase and a FM phase at 9K was observed with the critical field, HMT~200mT. A new magnetic phase between the new phase (lock-in phase) and an IC phase has been observed. From the field dependence of the Bragg reflections and their satellite peaks at low temperatures (3–12K), weak field driven first-order magnetic phase transitions were recorded at six fixed temperatures. The critical magnetic field decreases exponentially with the temperature. From these experimental results, we obtained a magnetic phase diagram of Tb0.95Er0.05Ni5 at a low temperature region for the first time

ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD

C9ORF72-derived dipeptide repeat proteins have emerged as the pathogenic cause of neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). However, the mechanisms underlying their expression are not fully understood. Here, we demonstrate that ZNF598, the rate-limiting factor for ribosome-associated quality control (RQC), co-translationally titrates the expression of C9ORF72-derived poly(GR) protein. A Drosophila genetic screen identified key RQC factors as potent modifiers of poly(GR)-induced neurodegeneration. ZNF598 overexpression in human neuroblastoma cells inhibited the nuclear accumulation of poly(GR) protein and decreased its cytotoxicity, whereas ZNF598 deletion had opposing effects. Poly(GR)-encoding sequences in the reporter RNAs caused translational stalling and generated ribosome-associated translation products, sharing molecular signatures with canonical RQC substrates. Furthermore, ZNF598 and listerin 1, the RQC E3 ubiquitin-protein ligase, promoted poly(GR) degradation via the ubiquitin-proteasome pathway. An ALS-relevant ZNF598(R69C) mutant displayed loss-of-function effects on poly(GR) expression, as well as on general RQC. Moreover, RQC function was impaired in C9-ALS patient-derived neurons, whereas lentiviral overexpression of ZNF598 lowered their poly(GR) expression and suppressed proapoptotic caspase-3 activation. Taken together, we propose that an adaptive nature of the RQC-relevant ZNF598 activity allows the co-translational surveillance to cope with the atypical expression of pathogenic poly(GR) protein, thereby acquiring a neuroprotective function in C9-ALS/FTD

Data from: Antitropicality and convergent evolution: a case study of Permian neospiriferine brachiopods

Antitropical distribution is a biogeographical pattern characterized by natural occurrences of the same species or members of the same clade in the middle- or middle-to-high-latitudinal habitats of both hemispheres, either on land or in marine environments, without appearing in the intervening tropical environments. For most of the noted examples of Permian antitropical distribution, particularly in marine invertebrates, the causes of disjunctions have been mainly linked to either dispersal or vicariance models. Little attention has been paid to other possible mechanisms. This study investigated the antitropicality of some Permian neospiriferine brachiopods through detailed taxonomic revision, comparison of palaeobiogeographical distribution, and a phylogenetic analysis. Several species, previously assigned to Kaninospirifer, are here reassigned to other genera, especially to Fasciculatia in the northern hemisphere and to Quadrospira in the southern hemisphere during the Permian. Both Kaninospirifer and Fasciculatia appear to have been restricted to north-western Pangea and north-eastern Asia during the Permian, but there is no robust evidence to suggest their presence in the southern hemisphere to which Imperiospira and Quadrospira were confined. In spite of the distributional separation between the two pairs of neospiriferine genera in the Permian palaeobiogeographical regime, they share considerable numbers of morphological characters, such as a large shell, subdued fasciculation, and reduction of ventral adminicula. Notwithstanding these morphological similarities, our phylogenetic reconstruction of the neospiriferines does not support a close relationship between these genera. This therefore must indicate that these similar morphological features were independently acquired, probably with these taxa living in spatially separate but ecologically compatible environmental conditions in the mid-latitudinal area of each hemisphere during the Permian. We regard this as an example of convergent evolution