Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk.

ObjectiveWe sought to estimate the causal effect of low serum 25(OH)D on multiple sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or subject to reverse causality.MethodsWe conducted mendelian randomization (MR) analyses using an instrumental variable (IV) comprising 3 single nucleotide polymorphisms found to be associated with serum 25(OH)D levels at genome-wide significance. We analyzed the effect of the IV on MS risk and both age at onset and disease severity in 2 separate populations using logistic regression models that controlled for sex, year of birth, smoking, education, genetic ancestry, body mass index at age 18-20 years or in 20s, a weighted genetic risk score for 110 known MS-associated variants, and the presence of one or more HLA-DRB1*15:01 alleles.ResultsFindings from MR analyses using the IV showed increasing levels of 25(OH)D are associated with a decreased risk of MS in both populations. In white, non-Hispanic members of Kaiser Permanente Northern California (1,056 MS cases and 9,015 controls), the odds ratio (OR) was 0.79 (p = 0.04, 95% confidence interval (CI): 0.64-0.99). In members of a Swedish population from the Epidemiological Investigation of Multiple Sclerosis and Genes and Environment in Multiple Sclerosis MS case-control studies (6,335 cases and 5,762 controls), the OR was 0.86 (p = 0.03, 95% CI: 0.76-0.98). A meta-analysis of the 2 populations gave a combined OR of 0.85 (p = 0.003, 95% CI: 0.76-0.94). No association was observed for age at onset or disease severity.ConclusionsThese results provide strong evidence that low serum 25(OH)D concentration is a cause of MS, independent of established risk factors

Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesMultiple sclerosis (MS) is an autoimmune disease with both genetic and environmental risk factors. Recent studies indicate that childhood and adolescent obesity double the risk of MS, but this association may reflect unmeasured confounders rather than causal effects of obesity. We used separate-sample Mendelian randomization to estimate the causal effect of body mass index (BMI) on susceptibility to MS. Using data from non-Hispanic white members of the Kaiser Permanente Medical Care Plan of Northern California (KPNC) (2006-2014; 1,104 cases of MS and 10,536 controls) and a replication data set from Sweden (the Epidemiological Investigation of MS (EIMS) and the Genes and Environment in MS (GEMS) studies, 2005-2013; 5,133 MS cases and 4,718 controls), we constructed a weighted genetic risk score using 97 variants previously established to predict BMI. Results were adjusted for birth year, sex, education, smoking status, ancestry, and genetic predictors of MS. Estimates in KPNC and Swedish data sets suggested that higher genetically induced BMI predicted greater susceptibility to MS (odds ratio = 1.13, 95% confidence interval: 1.04, 1.22 for the KPNC sample; odds ratio = 1.09, 95% confidence interval: 1.03, 1.15 for the Swedish sample). Although the mechanism remains unclear, to our knowledge, these findings support a causal effect of increased BMI on susceptibility to MS for the first time, and they suggest a role for inflammatory pathways that characterize both obesity and the MS disease process.National Institute of Neurological Disorders and Stroke National Institute of Allergy and Infectious Diseases Robert Wood Johnson Foundation Wayne and Gladys Valley Foundation Ellison Medical Foundation AFA Foundation Knut and Alice Wallenberg Foundation Swedish Brain Foundation Margareta af Ugglas Foundation European Union Seventh Framework Programme NEURINOX Swedish Medical Research Council Swedish Research Council for Health, Working Life, and Welfare Biogen Inc Merck Serono Teva Neuroscience Sanofi Novartis Bayer Schering Pharma Swedish Research Council Swedish Childhood Diabetes Foundation Neurologiskt Handikappades Riksforbund Foundation Genzyme Merck Bioge

Word Fluency Ability and Analogical Reasoning in Children with Cochlear Implants Compared to Normal-Hearing Children

Ett fåtal tidigare studier har visat att barn med cochleaimplantat (CI) har sämre förmåga till såväl ordflöde som verbalt analogiskt resonerande jämfört med normalhörande barn. Det finns ett förhållande mellan språk och analogiskt resonerande, men förhållandet mellan ordflödesförmåga och förmågan till analogiskt resonerande har inte undersökts tidigare för varken barn med CI eller normalhörande barn, vilket motiverar föreliggande studie. Syftet var att undersöka huruvida det finns skillnader mellan barn med CI och normalhörande barn vad gäller ordflöde och analogiskt resonerande. Studien syftade även till att undersöka förhållandet mellan ordflöde och analogiskt resonerande hos barn med CI respektive normalhörande barn. Nio barn med CI i åldrarna 6;4–8;2 år och en kontrollgrupp av trettio normalhörande barn i åldrarna 6;1–7;1 år medverkade. Ordflödesförmågan undersöktes med det fonologiska ordflödestestet FAS och det semantiska ordflödestestet Djur. Visuellt analogiskt resonerande undersöktes med AnimaLogica och verbalt analogiskt resonerande undersöktes med deltestet Auditiv analogi från Illinois Test of Psycholinguistic Abilities-3 (ITPA-3). I föreliggande studie har barnen med CI sämre ordflödesförmåga och analogiskt resonerande än de normalhörande barnen. Det finns ett samband mellan semantiskt ordflöde och verbalt analogiskt resonerande hos normalhörande barn, med ett liknande mönster hos barn med CI. Förmågan till ordflöde och analogiskt resonerande samt sambandet mellan dessa förmågor har klinisk relevans för logopeden i och med att detta blir ännu en aspekt att ta hänsyn till vid språkliga utredningar och behandlingar hos såväl normalhörande som barn med CI.Previous studies have shown that children with cochlear implant (CI) have worse word fluency abilities and analogical reasoning abilities compared to normal-hearing children. There is a relationship between language and analogical reasoning. However, a possible relationship between word fluency and analogical reasoning has not been studied before among children with CI or among normal-hearing children. This warrants the present study, which aimed to examine if there are differences between children with CI and normal-hearing children regarding word fluency and analogical reasoning. The study also aimed to examine the relationship between word fluency and analogical reasoning in children with CI and normal-hearing children. The present study involved nine children with CI aged 6;4–8;2 years and thirty normal-hearing children aged 6;1–7;1 years. Word fluency was examined using the phonological word fluency test FAS and the semantic word fluency test Animal. Visual analogical reasoning was examined using AnimaLogica and verbal analogical reasoning using Spoken Analogies from Illinois Test of Psycholinguistic Abilities-3 (ITPA-3). The results of the present study show that the children with CI had poorer word fluency ability and analogical reasoning compared to the normal-hearing children. A relationship between semantic word fluency and verbal analogical reasoning in normal-hearing children was found, with the children with CI showing the same trend. Word fluency ability and analogical reasoning and their relationship has a clinical relevance for speech-language pathologists since this must be considered when investigating and treating language difficulties in children with CI as well as normal-hearing children

Word Fluency Ability and Analogical Reasoning in Children with Cochlear Implants Compared to Normal-Hearing Children

Ett fåtal tidigare studier har visat att barn med cochleaimplantat (CI) har sämre förmåga till såväl ordflöde som verbalt analogiskt resonerande jämfört med normalhörande barn. Det finns ett förhållande mellan språk och analogiskt resonerande, men förhållandet mellan ordflödesförmåga och förmågan till analogiskt resonerande har inte undersökts tidigare för varken barn med CI eller normalhörande barn, vilket motiverar föreliggande studie. Syftet var att undersöka huruvida det finns skillnader mellan barn med CI och normalhörande barn vad gäller ordflöde och analogiskt resonerande. Studien syftade även till att undersöka förhållandet mellan ordflöde och analogiskt resonerande hos barn med CI respektive normalhörande barn. Nio barn med CI i åldrarna 6;4–8;2 år och en kontrollgrupp av trettio normalhörande barn i åldrarna 6;1–7;1 år medverkade. Ordflödesförmågan undersöktes med det fonologiska ordflödestestet FAS och det semantiska ordflödestestet Djur. Visuellt analogiskt resonerande undersöktes med AnimaLogica och verbalt analogiskt resonerande undersöktes med deltestet Auditiv analogi från Illinois Test of Psycholinguistic Abilities-3 (ITPA-3). I föreliggande studie har barnen med CI sämre ordflödesförmåga och analogiskt resonerande än de normalhörande barnen. Det finns ett samband mellan semantiskt ordflöde och verbalt analogiskt resonerande hos normalhörande barn, med ett liknande mönster hos barn med CI. Förmågan till ordflöde och analogiskt resonerande samt sambandet mellan dessa förmågor har klinisk relevans för logopeden i och med att detta blir ännu en aspekt att ta hänsyn till vid språkliga utredningar och behandlingar hos såväl normalhörande som barn med CI.Previous studies have shown that children with cochlear implant (CI) have worse word fluency abilities and analogical reasoning abilities compared to normal-hearing children. There is a relationship between language and analogical reasoning. However, a possible relationship between word fluency and analogical reasoning has not been studied before among children with CI or among normal-hearing children. This warrants the present study, which aimed to examine if there are differences between children with CI and normal-hearing children regarding word fluency and analogical reasoning. The study also aimed to examine the relationship between word fluency and analogical reasoning in children with CI and normal-hearing children. The present study involved nine children with CI aged 6;4–8;2 years and thirty normal-hearing children aged 6;1–7;1 years. Word fluency was examined using the phonological word fluency test FAS and the semantic word fluency test Animal. Visual analogical reasoning was examined using AnimaLogica and verbal analogical reasoning using Spoken Analogies from Illinois Test of Psycholinguistic Abilities-3 (ITPA-3). The results of the present study show that the children with CI had poorer word fluency ability and analogical reasoning compared to the normal-hearing children. A relationship between semantic word fluency and verbal analogical reasoning in normal-hearing children was found, with the children with CI showing the same trend. Word fluency ability and analogical reasoning and their relationship has a clinical relevance for speech-language pathologists since this must be considered when investigating and treating language difficulties in children with CI as well as normal-hearing children

MADRES Y FAMILIARES DE VÍCTIMAS DE FEMINICIDIO EN MÉXICO: HABITUS, PODER Y LUCHA SIMBÓLICA ANTE LA VIOLENCIA DE ESTADO

En un sentido distinto, la presente investigación pretende arrojar luz sobre aquellas victimas que pasan por momentos desapercibidas, ya sea en la vida cotidiana, la escena política e incluso para la academia. Estas son los familiares de las víctimas de feminicidio, en su mayoría madres, que ante la ineficacia de un Estado para proporcionar seguridad a las mujeres y de un sistema descompuesto de administración de justicia, se lanzan a ser las principales impulsoras de sus propios casos, rompiendo con lo esperado en razón de las posiciones precarias que ocupan dentro del campo social

Smoking and Epstein–Barr virus infection in multiple sclerosis development

Abstract It is unclear whether smoking interacts with different aspects of Epstein–Barr virus (EBV) infection with regard to multiple sclerosis (MS) risk. We aimed to investigate whether smoking acts synergistically with elevated EBNA-1 antibody levels or infectious mononucleosis (IM) history regarding MS risk. Two Swedish population-based case–control studies were used (6,340 cases and 6,219 matched controls). Subjects with different smoking, EBNA-1 and IM status were compared regarding MS risk, by calculating odds ratios (OR) with 95% confidence intervals (CI) employing logistic regression. Potential interaction on the additive scale was evaluated by calculating the attributable proportion due to interaction (AP). Current and past smokers had higher EBNA-1 antibody levels than never smokers (p < 0.0001). There was an additive interaction between current smoking and high EBNA-1 antibody levels (AP 0.3, 95% CI 0.2–0.4), but not between past smoking and high EBNA-1 antibody levels (AP 0.01, 95% CI − 0.1 to 0.1), with regard to MS risk. An interaction also occurred between current smoking and IM history (AP 0.2, 95% CI 0.004–0.4), but not between past smoking and IM history (AP − 0.06, 95% CI − 0.4 to 0.3). Current smoking increases EBNA-1 antibody levels and acts synergistically with both aspects of EBV infection to increase MS risk, indicating that there is at least one pathway to disease in which both risk factors are involved