3,819 research outputs found
Understanding of Relation Structures of Graphical Models by Lower Secondary Students
A learning path has been developed on system dynamical graphical modelling, integrated into the Dutch lower secondary physics curriculum. As part of the developmental research for this learning path, students’ understanding of the relation structures shown in the diagrams of graphical system dynamics based models has been investigated. One of our main findings is that only some students understand these structures correctly. Reality-based interpretation of the diagrams can conceal an incorrect understanding of diagram structures. As a result, students seemingly have no problems interpreting the diagrams until they are asked to construct a graphical model. Misconceptions have been identified that are the consequence of the fact that the equations are not clearly communicated by the diagrams or because the icons used in the diagrams mislead novice modellers. Suggestions are made for improvements
New attempts to understand nanodiamond stardust
We report on a concerted effort aimed at understanding the origin and history
of the pre-solar nanodiamonds in meteorites including the astrophysical sources
of the observed isotopic abundance signatures. This includes measurement of
light elements by secondary ion mass spectrometry (SIMS), analysis of
additional heavy trace elements by accelerator mass spectrometry (AMS) and
dynamic calculations of r-process nucleosynthesis with updated nuclear
properties. Results obtained indicate: a) there is no evidence for the former
presence of now extinct 26Al and 44Ti in our diamond samples other than what
can be attributed to silicon carbide and other "impurities"; this does not
offer support for a supernova (SN) origin but neither does it negate it; b)
analysis by AMS of platinum in "bulk diamond" yields an overabundance of r-only
198Pt that at face value seems more consistent with the neutron burst than with
the separation model for the origin of heavy trace elements in the diamonds,
although this conclusion is not firm given analytical uncertainties; c) if the
Xe-H pattern was established by an unadulterated r-process, it must have been a
strong variant of the main r-process, which possibly could also account for the
new observations in platinum.Comment: Workshop on Astronomy with Radioactvities VII; Publications of the
Astronomical Society of Australia, accepte
A new approach to deformation equations of noncommutative KP hierarchies
Partly inspired by Sato's theory of the Kadomtsev-Petviashvili (KP)
hierarchy, we start with a quite general hierarchy of linear ordinary
differential equations in a space of matrices and derive from it a matrix
Riccati hierarchy. The latter is then shown to exhibit an underlying 'weakly
nonassociative' (WNA) algebra structure, from which we can conclude, refering
to previous work, that any solution of the Riccati system also solves the
potential KP hierarchy (in the corresponding matrix algebra). We then turn to
the case where the components of the matrices are multiplied using a
(generalized) star product. Associated with the deformation parameters, there
are additional symmetries (flow equations) which enlarge the respective KP
hierarchy. They have a compact formulation in terms of the WNA structure. We
also present a formulation of the KP hierarchy equations themselves as
deformation flow equations.Comment: 25 page
Explorations of the Extended ncKP Hierarchy
A recently obtained extension (xncKP) of the Moyal-deformed KP hierarchy
(ncKP hierarchy) by a set of evolution equations in the Moyal-deformation
parameters is further explored. Formulae are derived to compute these equations
efficiently. Reductions of the xncKP hierarchy are treated, in particular to
the extended ncKdV and ncBoussinesq hierarchies. Furthermore, a good part of
the Sato formalism for the KP hierarchy is carried over to the generalized
framework. In particular, the well-known bilinear identity theorem for the KP
hierarchy, expressed in terms of the (formal) Baker-Akhiezer function, extends
to the xncKP hierarchy. Moreover, it is demonstrated that N-soliton solutions
of the ncKP equation are also solutions of the first few deformation equations.
This is shown to be related to the existence of certain families of algebraic
identities.Comment: 34 pages, correction of typos in (7.2) and (7.5
Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation
Protein posttranslational modifications (PTMs) play a central role in the DNA damage response. In particular, protein phosphorylation and ubiquitination have been shown to be essential in the signaling cascade that coordinates break repair with cell cycle progression. Here, we performed whole-cell quantitative proteomics to identify global changes in protein ubiquitination that are induced by DNA double-strand breaks. In total, we quantified more than 9,400 ubiquitin sites and found that the relative abundance of similar to 10% of these sites was altered in response to DNA double-strand breaks. Interestingly, a large proportion of ribosomal proteins, including those from the 40S as well as the 60S subunit, were ubiquitinated in response to DNA damage. In parallel, we discovered that DNA damage leads to the inhibition of ribosome function. Taken together, these data uncover the ribosome as a major target of the DNA damage response.This work is funded by a TOP-GO grant from the Netherlands Organization for Scientific Research (NWO ZonMW 912100651 to R.H.M., S.M., and V.A.H.). I.G.S. was supported with a postdoctoral fellowship from the Basque Country Government (Spain). We thank Christian Frese and Teck Yew Low for fruitful discussions. We also thank Teck Yew Low for submitting the raw files and annotated spectra to PRIDE. We thank Fabricio Loayza-Puch for his technical help with the sucrose gradients
Suppressed Charge Dispersion via Resonant Tunneling in a Single-Channel Transmon
We demonstrate strong suppression of charge dispersion in a
semiconductor-based transmon qubit across Josephson resonances associated with
a quantum dot in the junction. On resonance, dispersion is drastically reduced
compared to conventional transmons with corresponding Josephson and charging
energies. We develop a model of qubit dispersion for a single-channel
resonance, which is in quantitative agreement with experimental data
- …