Giving a name to nameless victims: patients and the Nazi euthanasia program

Lecture by Patricia Heberer Ph.D., Historian, United States Holocaust Memorial Museum, Washington, D.C., held April 19, 2012 at the University of New Hampshire, as part of the lecture series entitled Medical Ethics and Human Subject Research in the Shadow of the Holocaus

Emerging pollutants and plants – Metabolic activation of diclofenac by peroxidases

Human pharmaceuticals and their residues are constantly detected in our waterbodies, due to poor elimination rates, even in the most advanced waste water treatment plants. Their impact on the environment and human health still remains unclear. When phytoremediation is applied to aid water treatment, plants may transform and degrade xenobiotic contaminants through phase I and phase II metabolism to more water soluble and less toxic intermediates. In this context, peroxidases play a major role in activating compounds during phase I via oxidation. In the present work, the ability of a plant peroxidase to oxidize the human painkiller diclofenac was confirmed using stopped flow spectroscopy in combination with LC-MS analysis. Analysis of an orange colored product revealed the structure of the highly reactive Diclofenac-2,5-Iminoquinone, which may be the precursor of several biological conjugates and breakdown products in plan