Halo detection via large-scale Bayesian inference

We present a proof-of-concept of a novel and fully Bayesian methodology designed to detect halos of different masses in cosmological observations subject to noise and systematic uncertainties. Our methodology combines the previously published Bayesian large-scale structure inference algorithm, HADES, and a Bayesian chain rule (the Blackwell-Rao Estimator), which we use to connect the inferred density field to the properties of dark matter halos. To demonstrate the capability of our approach we construct a realistic galaxy mock catalogue emulating the wide-area 6-degree Field Galaxy Survey, which has a median redshift of approximately 0.05. Application of HADES to the catalogue provides us with accurately inferred three-dimensional density fields and corresponding quantification of uncertainties inherent to any cosmological observation. We then use a cosmological simulation to relate the amplitude of the density field to the probability of detecting a halo with mass above a specified threshold. With this information we can sum over the HADES density field realisations to construct maps of detection probabilities and demonstrate the validity of this approach within our mock scenario. We find that the probability of successful of detection of halos in the mock catalogue increases as a function of the signal-to-noise of the local galaxy observations. Our proposed methodology can easily be extended to account for more complex scientific questions and is a promising novel tool to analyse the cosmic large-scale structure in observations.Comment: 17 pages, 13 figures. Accepted for publication in MNRAS following moderate correction

The 6dF Galaxy Survey: Dependence of halo occupation on stellar mass

In this paper we study the stellar-mass dependence of galaxy clustering in the 6dF Galaxy Survey. The near-infrared selection of 6dFGS allows more reliable stellar mass estimates compared to optical bands used in other galaxy surveys. Using the Halo Occupation Distribution (HOD) model, we investigate the trend of dark matter halo mass and satellite fraction with stellar mass by measuring the projected correlation function, $w_p(r_p)$. We find that the typical halo mass ($M_1$) as well as the satellite power law index ($\alpha$) increase with stellar mass. This indicates, (1) that galaxies with higher stellar mass sit in more massive dark matter halos and (2) that these more massive dark matter halos accumulate satellites faster with growing mass compared to halos occupied by low stellar mass galaxies. Furthermore we find a relation between $M_1$ and the minimum dark matter halo mass ($M_{\rm min}$) of $M_1 \approx 22\,M_{\rm min}$, in agreement with similar findings for SDSS galaxies. The satellite fraction of 6dFGS galaxies declines with increasing stellar mass from 21% at $M_{\rm stellar} = 2.6\times10^{10}h^{-2}\,M_{\odot}$ to 12% at $M_{\rm stellar} = 5.4\times10^{10}h^{-2}\,M_{\odot}$ indicating that high stellar mass galaxies are more likely to be central galaxies. We compare our results to two different semi-analytic models derived from the Millennium Simulation, finding some disagreement. Our results can be used for placing new constraints on semi-analytic models in the future, particularly the behaviour of luminous red satellites. Finally we compare our results to studies of halo occupation using galaxy-galaxy weak lensing. We find good overall agreement, representing a valuable crosscheck for these two different tools of studying the matter distribution in the Universe.Comment: 17 pages, 11 figures. arXiv admin note: text overlap with arXiv:1104.2447 by other author

Vaccination against Allergy: A Paradigm Shift?

Since the discovery that IgE antibodies mediate allergy, decades of research have unraveled complex mechanisms associated with conventional immunotherapy and the vital protagonists that shape 'immune tolerance' to allergens. Debate exists on what should constitute the dominant effector mechanism in driving rational drug designs for next-generation immunotherapies. As vaccine technology continues to advance, the development of novel vaccines in this area of continued medical need might stand on a threshold of breakthrough inspired by experiments by Dunbar on the passive vaccination of allergic animals more than 100 years ago. In this opinion article, we discuss both novel insights into IgG antibodies as the principle effector modality induced by specific immunotherapy and advances in antigen-carrier design that may catapult allergy treatment into our modern world

Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2

Focal segmental glomerulosclerosis (FSGS) is a devastating form of nephrotic syndrome which ultimately leads to end stage renal failure (ESRF). Mutations in inverted formin 2 (INF2), a member of the formin family of actin-regulating proteins, have recently been associated with a familial cause of nephrotic syndrome characterized by FSGS. INF2 is a unique formin that can both polymerize and depolymerize actin filaments. How mutations in INF2 lead to disease is unknown. In the present study, we show that three mutations associated with FSGS, E184K, S186P and R218Q, reduce INF2 auto-inhibition and increase association with monomeric actin. Furthermore using a combination of GFP–INF2 expression in human podocytes and GFP-Trap purification coupled with MS we demonstrate that INF2 interacts with profilin 2 and the F-actin capping protein, CapZ α-1. These interactions are increased by the presence of the disease causing mutations. Since both these proteins are involved in the dynamic turnover and restructuring of the actin cytoskeleton these changes strengthen the evidence that aberrant regulation of actin dynamics underlies the pathogenesis of disease

The Southern 2MASS AGN Survey: spectroscopic follow-up with 6dF

The Two Micron All-Sky Survey (2MASS) has provided a uniform photometric catalog to search for previously unknown red AGN and QSOs. We have extended the search to the southern equatorial sky by obtaining spectra for 1182 AGN candidates using the 6dF multifibre spectrograph on the UK Schmidt Telescope. These were scheduled as auxiliary targets for the 6dF Galaxy Redshift Survey. The candidates were selected using a single color cut of J - Ks > 2 to Ks ~ 15.5 and a galactic latitude of |b|>30 deg. 432 spectra were of sufficient quality to enable a reliable classification. 116 sources (or ~27%) were securely classified as type 1 AGN, 20 as probable type 1s, and 57 as probable type 2 AGN. Most of them span the redshift range 0.05<z<0.5 and only 8 (or ~6%) were previously identified as AGN or QSOs. Our selection leads to a significantly higher AGN identification rate amongst local galaxies (>20%) than in any previous galaxy survey. A small fraction of the type 1 AGN could have their optical colors reddened by optically thin dust with A_V<2 mag relative to optically selected QSOs. A handful show evidence for excess far-IR emission. The equivalent width (EW) and color distributions of the type 1 and 2 AGN are consistent with AGN unified models. In particular, the EW of the [OIII] emission line weakly correlates with optical--near-IR color in each class of AGN, suggesting anisotropic obscuration of the AGN continuum. Overall, the optical properties of the 2MASS red AGN are not dramatically different from those of optically-selected QSOs. Our near-IR selection appears to detect the most near-IR luminous QSOs in the local universe to z~0.6 and provides incentive to extend the search to deeper near-IR surveys.Comment: 57 pages, 12 figures, 4 tables, to appear in vol.27/4 of Publications of the Astronomical Society of Australia (PASA

Halo detection via large-scale Bayesian inference

We present a proof-of-concept of a novel and fully Bayesian methodology designed to detect haloes of different masses in cosmological observations subject to noise and systematic uncertainties. Our methodology combines the previously published Bayesian large-scale structure inference algorithm, HAmiltonian Density Estimation and Sampling algorithm (HADES), and a Bayesian chain rule (the Blackwell–Rao estimator), which we use to connect the inferred density field to the properties of dark matter haloes. To demonstrate the capability of our approach, we construct a realistic galaxy mock catalogue emulating the wide-area 6-degree Field Galaxy Survey, which has a median redshift of approximately 0.05. Application of HADES to the catalogue provides us with accurately inferred three-dimensional density fields and corresponding quantification of uncertainties inherent to any cosmological observation. We then use a cosmological simulation to relate the amplitude of the density field to the probability of detecting a halo with mass above a specified threshold. With this information, we can sum over the HADES density field realisations to construct maps of detection probabilities and demonstrate the validity of this approach within our mock scenario. We find that the probability of successful detection of haloes in the mock catalogue increases as a function of the signal to noise of the local galaxy observations. Our proposed methodology can easily be extended to account for more complex scientific questions and is a promising novel tool to analyse the cosmic large-scale structure in observations. Key words: methods: numerical – methods: statistical – galaxies: haloes – galaxies: clusters

Second Data Release of the 6dF Galaxy Survey

The 6dF Galaxy Survey is measuring around 150000 redshifts and 15000 peculiar velocities from galaxies over the southern sky at |b|>10 degrees. When complete, it will be the largest survey of its kind by more than an order of magnitude. Here we describe the characteristics of the Second Incremental Data Release (DR2) and provide an update of the survey. This follows earlier data made public in December 2002 and March 2004. A total of 83014 sources now have their spectra, redshifts, near-infrared and optical photometry available online and searchable through an SQL database at http://www-wfau.roe.ac.uk/6dFGS/.Comment: 11 pages, 7 figures. Submitted to PASA. High resolution versions of the figures can be obtained from http://www.aao.gov.au/local/www/6df/Publication

Focusing a NIR adaptive optics imager, experience with GSAOI

The Gemini South Adaptive Optics Imager (GSAOI) to be used with the Multi-Conjugate Adaptive Optics (MCAO) system at Gemini South is currently in the final stages of assembly and testing. GSAOI uses a suite of 26 different filters, made from both BK7 and Fused Silica substrates. These filters, located in a non-collimated beam, work as active optical elements. The optical design was undertaken to ensure that both the filter substrates both focused longitudinally at the same point. During the testing of the instrument it was found that longitudinal focus was filter dependant. The methods used to investigate this are outlined in the paper. These investigations identified several possible causes for the focal shift including substrate material properties in cryogenic conditions and small amounts of residual filter power

The 6df galaxy survey: The near-infrared fundamental plane of early-type galaxies

We determine the near-infrared Fundamental Plane (FP) for ~10 4 early-type galaxies in the 6-degree Field Galaxy Survey (6dFGS). We fit the distribution of central velocity dispersion, near-infrared surface brightness and half-light radius with a 3D Gaussian model using a maximum-likelihood method. The model provides an excellent empirical fit to the observed FP distribution and the method proves robust and unbiased. Tests using simulations show that it gives superior results to regression techniques in the presence of significant and correlated uncertainties in all three parameters, censoring of the data by various selection effects and outliers in the data sample. For the 6dFGS J-band sample we find an FP with Re∝σ01.52±0.03Ie-0.89±0.01, similar to previous near-infrared determinations and consistent with the H- and K-band FPs once allowance is made for differences in mean colour. The overall scatter in R e about the FP is σ r = 29 per cent, and is the quadrature sum of an 18 per cent scatter due to observational errors and a 23 per cent intrinsic scatter. Because of the Gaussian distribution of galaxies in FP space, σ r is not the distance error, which we find to be σ d = 23 per cent. Using group richness and local density as measures of environment, and morphologies based on visual classifications, we find that the FP slopes do not vary with environment or morphology. However, for fixed velocity dispersion and surface brightness, field galaxies are on average 5 per cent larger than galaxies in groups or higher density environments, and the bulges of early-type spirals are on average 10 per cent larger than ellipticals and lenticulars. The residuals about the FP show significant trends with environment, morphology and stellar population. The strongest trend is with age, and we speculate that age is the most important systematic source of offsets from the FP, and may drive the other trends through its correlations with environment, morphology and metallicity. These results will inform our use of the near-infrared FP in deriving relative distances and peculiar velocities for 6dFGS galaxies