The Prospective Role of Plant Products in Radiotherapy of Cancer: A Current Overview

Treatment of cancer often requires exposure to radiation, which has several limitations involving non-specific toxicity toward normal cells, reducing the efficacy of treatment. Efforts are going on to find chemical compounds which would effectively offer protection to the normal tissues after radiation exposure during radiotherapy of cancer. In this regard, plant-derived compounds might serve as “leads” to design ideal radioprotectors/radiosensitizers. This article reviews some of the recent findings on prospective medicinal plants, phytochemicals, and their analogs, based on both in vitro and in vivo tumor models especially focused with relevance to cancer radiotherapy. Also, pertinent discussion has been presented on the molecular mechanism of apoptotic death in relation to the oxidative stress in cancer cells induced by some of these plant samples and their active constituents

SUCCESSFUL AND STENTING OF THORACO ABDOMINAL IN A CASE OF MEDIAN ARCUATE LIGAMENT SYNDROME

Median Arcuate Ligament Syndrome (MALS) or Celiac Artery Compression Syndrome (CACS) is a rare clinical entity, and presents as symptoms of acute intestinal obstruction. CT angiography is diagnostic in a hemodynamically stable patient. Treatment modalities of choice still remain controversial. In patients with acute presentations it is usually managed by surgical (exploratory laparotomy/ laparoscopic) repair or endovascular repair or combined interventions. We hereby present a case of 33 years old gentleman who was diagnosed to have acute intestinal obstruction secondary to MALS and underwent emergency exploratory laparotomy, adhesiolysis and release of median arcuate ligament followed by angioplasty and stenting of the Thoracic Aorta

Chemistry of enediynyl azides: activation through a novel pathway

The spontaneous activation of a nonaromatic enediynyl azide under ambient conditions has been demonstrated. The aromatic enediyne followed the expected cycloaddition with the alkene in the neighbouring arm to form a stable bridged bicyclic enediyne

Therapeutic uses of Tamra (copper) Bhasma - A review through Ayurved Samgraha and other texts

Materia Medica of Ayurveda is using best scientific and applied Rasa Chikitsa and Rasa Ausadhi occupied an important place in the field of Ayurvedic practice. It deals with metal, minerals and poisonous drug. Starting from 9th century AD to 16th century AD was the sunshine period of Rasa Chikitsa, then gradually decline probably due to introduction of western medicine. It’s efficacy is superior than plant formulation due to its unlimited expiry, effective in small dose, abundant resource and quickly effective on the target tissue even it can handle emergency situations also but the most important background of Rasa Ausadhi received highly technical processing (Shodhan, Marana, Jarana[1]) for the treatment of diseases. In this content liver function test and estimation of renal profile (before and after) will help for gaining confidence both in patient and physician prior to use compound formulations containing Tamra Bhasma. Tamra Bhasma is a metal compound which is used for treatment of various disease like Jwara, Bala Roga, Grahani Roga, Pandu, Visarpa, Brishya, Yakrit Roga, Pliha Roga etc

Linking IPCC AR4 & AR5 frameworks for assessing vulnerability and risk to climate change in the Indian Bengal Delta

The International Panel on Climate Change (IPCC) AR5 (Fifth Assessment Report, 2014) conceptual approach and terminology is aligned with a concept of risk which differs from the previous framework (AR4). This study draws links between the AR5 concept of risk with the previous concept of vulnerability (AR4). The most significant difference between the results of the AR4 and AR5 approaches is the change in sub-district level relative rankings. Findings show that Basanti, in the Bengal Delta, is the most vulnerable sub-district using the AR4 approach, whereas Gosaba is found to be highly exposed to risk using the AR5 approach.UK Government's Department for International Development (DFID

Joint Effects of Colorectal Cancer Susceptibility Loci, Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer

Background: Genome wide association studies (GWAS) have identified several SNPs associated with colorectal cancer (CRC) susceptibility. Vitamin D is also inversely associated with CRC risk. Methods: We examined main and joint effects of previously GWAS identified genetic markers of CRC and plasma 25-hydroxyvitamin D (25(OH)D) on CRC risk in three prospective cohorts: the Nurses' Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and the Physicians' Health Study (PHS). We included 1895 CRC cases and 2806 controls with genomic DNA. We calculated odds ratios and 95% confidence intervals for CRC associated with additive genetic risk scores (GRSs) comprised of all CRC SNPs and subsets of these SNPs based on proximity to regions of increased vitamin D receptor binding to vitamin D response elements (VDREs), based on published ChiP-seq data. Among a subset of subjects with additional prediagnostic 25(OH)D we tested multiplicative interactions between plasma 25(OH)D and GRS's. We used fixed effects models to meta-analyze the three cohorts. Results: The per allele multivariate OR was 1.12 (95% CI, 1.06–1.19) for GRS-proximalVDRE; and 1.10 (95% CI, 1.06–1.14) for GRS-nonproxVDRE. The lowest quartile of plasma 25(OH)D compared with the highest, had a multivariate OR of 0.63 (95% CI, 0.48–0.82) for CRC. We did not observe any significant interactions between any GRSs and plasma 25(OH)D. Conclusions: We did not observe evidence for the modification of genetic susceptibility for CRC according to vitamin D status, or evidence that the effect of common CRC risk alleles differed according to their proximity to putative VDR binding sites

Social vulnerability to environmental hazards in the Ganges-Brahmaputra-Meghna delta, India and Bangladesh

The coastal areas of the Ganges-Brahmaputra-Meghna delta are acknowledged hotspots of environmental and social concerns. This reflects a large, mainly rural population of 56.7 million, which is exposed to a range of natural hazards exacerbated by climate change, sea-level rise and subsidence. There are high levels of poverty and limited social well-being, including poor access to education, health, drinking water, and sanitation facilities. A spatial assessment of social vulnerability can indicate which communities are more susceptible to environmental hazards, while a temporal assessment may indicate how such vulnerability is changing due to development and other drivers. This study provides the first analysis of social vulnerability across the entire coastal delta within Bangladesh and India. It uses consistent and common secondary data at the sub-district level for two time periods: 2001 and 2011. These are used to construct a socio-economic vulnerability index across the region using Principal Component Analysis. Three main conclusions emerge. Firstly, there is a cross-shore social vulnerability gradient across the whole delta, with more vulnerable people living near the coast. Here, the benefits of access to marine fisheries are not apparent. Secondly, non-agricultural development and economic expansion have reduced the vulnerability significantly, showing its benefits. Lastly, despite general positive development trends, shocks due to major cyclone landfall appear to have enhanced vulnerability in the impacted areas. Further comprehensive analysis across the whole delta is recommended to improve our understanding of the common threats and possible solutions

Plant Power:Opportunities and challenges for meeting sustainable energy needs from the plant and fungal kingdoms

Societal Impact Statement Bioenergy is a major component of the global transition to renewable energy technologies. The plant and fungal kingdoms offer great potential but remain mostly untapped. Their increased use could contribute to the renewable energy transition and addressing the United Nations Sustainable Development Goal 7 “Ensure access to affordable, reliable, sustainable and modern energy for all.” Current research focuses on species cultivated at scale in temperate regions, overlooking the wealth of potential new sources of small‐scale energy where they are most urgently needed. A shift towards diversified, accessible bioenergy technologies will help to mitigate and adapt to the threats of climate change, decrease energy poverty, improve human health by reducing indoor pollution, increase energy resilience of communities, and decrease greenhouse gas emissions from fossil fuels. Summary Bioenergy derived from plants and fungi is a major component of the global transition to renewable energy technologies. There is rich untapped diversity in the plant and fungal kingdoms that offers potential to contribute to the shift away from fossil fuels and to address the United Nations Sustainable Development Goal 7 (SDG7) “Ensure access to affordable, reliable, sustainable and modern energy for all.” Energy poverty—the lack of access to modern energy services—is most acute in the Global South where biodiversity is greatest and least investigated. Our systematic review of the literature over the last 5 years (2015–2020) indicates that research efforts have targeted a very small number of plant species cultivated at scale, mostly in temperate regions. The wealth of potential new sources of bioenergy in biodiverse regions, where the implementation of SDG7 is most urgently needed, has been largely overlooked. We recommend next steps for bioenergy stakeholders—research, industry, and government—to seize opportunities for innovation to alleviate energy poverty while protecting biodiversity. Small‐scale energy production using native plant species in bioenergy landscapes overcomes many pitfalls associated with bioenergy crop monocultures, such as biodiversity loss and conflict with food production. Targeted trait‐based screening of plant species and biological screening of fungi are required to characterize the potential of this resource. The benefits of diversified, accessible bioenergy go beyond the immediate urgency of energy poverty as more diverse agricultural landscapes are more resilient, store more carbon, and could also reduce the drivers of the climate and environmental emergencies

CHSI costing study-Challenges and solutions for cost data collection in private hospitals in India

INTRODUCTION: Ayushman Bharat Pradhan Mantri Jan Aarogya Yojana (AB PM-JAY) has enabled the Government of India to become a strategic purchaser of health care services from private providers. To generate base cost evidence for evidence-based policymaking the Costing of Health Services in India (CHSI) study was commissioned in 2018 for the price setting of health benefit packages. This paper reports the findings of a process evaluation of the cost data collection in the private hospitals. METHODS: The process evaluation of health system costing in private hospitals was an exploratory survey with mixed methods (quantitative and qualitative). We used three approaches-an online survey using a semi-structured questionnaire, in-depth interviews, and a review of monitoring data. The process of data collection was assessed in terms of time taken for different aspects, resources used, level and nature of difficulty encountered, challenges and solutions. RESULTS: The mean time taken for data collection in a private hospital was 9.31 (± 1.0) person months including time for obtaining permissions, actual data collection and entry, and addressing queries for data completeness and quality. The longest time was taken to collect data on human resources (30%), while it took the least time for collecting information on building and space (5%). On a scale of 1 (lowest) to 10 (highest) difficulty levels, the data on human resources was the most difficult to collect. This included data on salaries (8), time allocation (5.5) and leaves (5). DISCUSSION: Cost data from private hospitals is crucial for mixed health systems. Developing formal mechanisms of cost accounting data and data sharing as pre-requisites for empanelment under a national insurance scheme can significantly ease the process of cost data collection