1,293 research outputs found
SB114-13/14: Amending Fiscal Policy
SB114-13/14: Amending Fiscal Policy. This resolution passed with Unanimous Consent during the April 30, 2014 meeting of the Associated Students of the University of Montana (ASUM)
SB117-13/14: Amending Fiscal Policy
SB117-13/14: Amending Fiscal Policy. This resolution passed with Unanimous Consent during the April 30, 2014 meeting of the Associated Students of the University of Montana (ASUM)
SB110-13/14: Amending Fiscal Policy
SB110-13/14: Amending Fiscal Policy. This resolution passed with Unanimous Consent during the April 30, 2014 meeting of the Associated Students of the University of Montana (ASUM)
SB118-13/14: Amending Fiscal Policy
SB118-13/14: Amending Fiscal Policy. This resolution passed with Unanimous Consent during the April 30, 2014 meeting of the Associated Students of the University of Montana (ASUM)
SB116-13/14: Amending Fiscal Policy
SB116-13/14: Amending Fiscal Policy. This resolution passed with Unanimous Consent during the April 30, 2014 meeting of the Associated Students of the University of Montana (ASUM)
SB107-13/14: Amending Fiscal Policy
SB107-13/14: Amending Fiscal Policy. This resolution passed with Unanimous Consent during the April 30, 2014 meeting of the Associated Students of the University of Montana (ASUM)
SB112-13/14: Amending Fiscal Policy
SB112-13/14: Amending Fiscal Policy. This resolution passed with Unanimous Consent during the April 30, 2014 meeting of the Associated Students of the University of Montana (ASUM)
Debating DSM-5:diagnosis and the sociology of critique
The development of the fifth edition of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders—the DSM-5—has reenergised and driven further forward critical discourse about the place and role of diagnosis in mental health. The DSM-5 has attracted considerable criticism, not least about its role in processes of medicalisation. This paper suggests the need for a sociology of psychiatric critique. Sociological analysis can help map fields of contention, and cast fresh light on the assumptions and nuances of debate around the DSM-5; it underscores the importance of diagnosis to the governance of social and clinical life, as well as the wider discourses critical commentaries connect with and are activated by. More normatively, a sociology of critique can indicate which interests and values are structuring the dialogues being articulated, and just how diverse clinical opinion regarding the DSM can actually be. This has implications for the considerations of health services and policy decision-makers who might look to such debates for guidance
Conservation and global distribution of non-canonical antigens in enterotoxigenic Escherichia coli
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) cause significant diarrheal morbidity and mortality in children of resource-limited regions, warranting development of effective vaccine strategies. Genetic diversity of the ETEC pathovar has impeded development of broadly protective vaccines centered on the classical canonical antigens, the colonization factors and heat-labile toxin. Two non-canonical ETEC antigens, the EtpA adhesin, and the EatA mucinase are immunogenic in humans and protective in animal models. To foster rational vaccine design that complements existing strategies, we examined the distribution and molecular conservation of these antigens in a diverse population of ETEC isolates.
METHODS: Geographically diverse ETEC isolates (n = 1159) were interrogated by PCR, immunoblotting, and/or whole genome sequencing (n = 46) to examine antigen conservation. The most divergent proteins were purified and their core functions assessed in vitro.
RESULTS: EatA and EtpA or their coding sequences were present in 57.0% and 51.5% of the ETEC isolates overall, respectively; and were globally dispersed without significant regional differences in antigen distribution. These antigens also exhibited \u3e93% amino acid sequence identity with even the most divergent proteins retaining the core adhesin and mucinase activity assigned to the prototype molecules.
CONCLUSIONS: EtpA and EatA are well-conserved molecules in the ETEC pathovar, suggesting that they serve important roles in virulence and that they could be exploited for rational vaccine design
How to write a successful grant application: guidance provided by the European Society of Clinical Pharmacy.
Considering a rejection rate of 80–90%, the preparation of a research grant is often considered a daunting task since it is resource intensive and there is no guarantee of success, even for seasoned researchers. This commentary provides a summary of the key points a researcher needs to consider when writing a research grant proposal, outlining: (1) how to conceptualise the research idea; (2) how to find the right funding call; (3) the importance of planning; (4) how to write; (5) what to write, and (6) key questions for reflection during preparation. It attempts to explain the difficulties associated with finding calls in clinical pharmacy and advanced pharmacy practice, and how to overcome them. The commentary aims to assist all pharmacy practice and health services research colleagues new to the grant application process, as well as experienced researchers striving to improve their grant review scores. The guidance in this paper is part of ESCP’s commitment to stimulate "innovative and high-quality research in all areas of clinical pharmacy"
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