Influence of music genre and composition on entertainment noise limits

Liquor licensing authorities across Australia typically require an entertainment noise test to be conducted before a venue can host amplified entertainment. The purpose of this test is to simulate live entertainment in order to determine the maximum permissible noise source limits allowed for the venue. In this paper, several disadvantages of the current method used for entertainment noise testing are identified and discussed. It was found that the choice of music can affect the resulting source noise level limits. An alternative approach has been suggested which involves playing band-limited pink noise across the 63 to 2kHz octave bands. A correction is then applied to determine the source noise level limits associated with different genres of music. The advantages of this method are that it reduces the time required to conduct the test, the nuisance caused to neighbouring premises is reduced and the variance in source noise level limits caused by different choice of test music is eliminated

Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer\u27s disease

Alzheimer\u27s disease is the most common form of age-related neurodegenerative dementia. The disease is characterised by the presence of plaques in the cerebral cortex. The major constituent of these plaques is aggregated amyloid-β peptide. This review focuses on the molecular aspects of metal complexes designed to bind to amyloid-β. The development of radioactive metal-based complexes of copper and technetium designed as diagnostic imaging agents to detect amyloid burden in the brain is discussed. Separate sections of the review discuss the use of luminescent metal complexes to act as non-conventional probes of amyloid formation and recent research into the use of metal complexes as inhibitors of amyloid formation and toxicity

New perspectives on the annihilation electrogenerated chemiluminescence of mixed metal complexes in solution

Preliminary explorations of the annihilation electrogenerated chemiluminescence (ECL) of mixed metal complexes have revealed opportunities to enhance emission intensities and control the relative intensities from multiple luminophores through the applied potentials. However, the mechanisms of these systems are only poorly understood. Herein, we present a comprehensive characterisation of the annihilation ECL of mixtures of tris(2,2′-bipyridine)ruthenium(ii) hexafluorophosphate ([Ru(bpy)3](PF6)2) and fac-tris(2-phenylpyridine)iridium(iii) ([Ir(ppy)3]). This includes a detailed investigation of the change in emission intensity from each luminophore as a function of both the applied electrochemical potentials and the relative concentrations of the two complexes, and a direct comparison with two mixed (Ru/Ir) ECL systems for which emission from only the ruthenium-complex was previously reported. Concomitant emission from both luminophores was observed in all three systems, but only when: (1) the applied potentials were sufficient to generate the intermediates required to form the electronically excited state of both complexes; and (2) the concentration of the iridium complex (relative to the ruthenium complex) was sufficient to overcome quenching processes. Both enhancement and quenching of the ECL of the ruthenium complex was observed, depending on the experimental conditions. The observations were rationalised through several complementary mechanisms, including resonance energy transfer and various energetically favourable electron-transfer pathways

Scope for Credit Risk Diversification

This paper considers a simple model of credit risk and derives the limit distribution of losses under different assumptions regarding the structure of systematic risk and the nature of exposure or firm heterogeneity. We derive fat-tailed correlated loss distributions arising from Gaussian risk factors and explore the potential for risk diversification. Where possible the results are generalised to non-Gaussian distributions. The theoretical results indicate that if the firm parameters are heterogeneous but come from a common distribution, for sufficiently large portfolios there is no scope for further risk reduction through active portfolio management. However, if the firm parameters come from different distributions, then further risk reduction is possible by changing the portfolio weights. In either case, neglecting parameter heterogeneity can lead to underestimation of expected losses. But, once expected losses are controlled for, neglecting parameter heterogeneity can lead to overestimation of risk, whether measured by unexpected loss or value-at-risk

Temperatures of the Lacus Mortis Region of the Moon

Over 11&nbsp;years of data acquired by the Diviner Lunar Radiometer Experiment instrument aboard Lunar Reconnaissance Orbiter have been compiled into a comprehensive data set of surface temperatures in the Lacus Mortis region which includes the landing ellipse of the Astrobotic Mission One lander mission. These data provide diurnal brightness temperatures at 128 pixels per degree (ppd) spatial resolution and 0.1&nbsp;hr of local time resolution. From this data set, we highlight several features that display variations in radiative and thermophysical properties in the Lacus Mortis region and characterize the temperatures of the Astrobotic Mission One landing ellipse. We identify distinctly contrasting properties of materials in the walls of B&uuml;rg crater, hummocks of materials on the southeast margin of the mare basalts, and materials exposed or excavated by impacts. Additionally, we describe an exceptionally rocky fault scarp that predates the formation of B&uuml;rg crater suggesting the observed boulders are replenished on a timescale &lt;1&nbsp;Ga. Within the Astrobotic landing ellipse, temperatures are observed to range from &sim;88 to &sim;359&nbsp;K with sunrise and sunset local times constrained to 5.8&ndash;6.3&nbsp;hr and 17.8 and 18.1&nbsp;hr respectively. &nbsp;</p

Cu-II(atsm) Attenuates Neuroinflammation

Background: Neuroinflammation and biometal dyshomeostasis are key pathological features of several neurodegenerative diseases, including Alzheimer's disease (AD). Inflammation and biometals are linked at the molecular level through regulation of metal buffering proteins such as the metallothioneins. Even though the molecular connections between metals and inflammation have been demonstrated, little information exists on the effect of copper modulation on brain inflammation. Methods: We demonstrate the immunomodulatory potential of the copper bis(thiosemicarbazone) complex Cu-II(atsm) in an neuroinflammatory model in vivo and describe its anti-inflammatory effects on microglia and astrocytes in vitro. Results: By using a sophisticated in vivo magnetic resonance imaging (MRI) approach, we report the efficacy of Cu-II(atsm) in reducing acute cerebrovascular inflammation caused by peripheral administration of bacterial lipopolysaccharide (LPS). Cu-II(atsm) also induced anti-inflammatory outcomes in primary microglia [significant reductions in nitric oxide (NO), monocyte chemoattractant protein 1 (MCP-1), and tumor necrosis factor (TNF)] and astrocytes [significantly reduced NO, MCP-1, and interleukin 6 (IL-6)] in vitro. These anti-inflammatory actions were associated with increased cellular copper levels and increased the neuroprotective protein metallothionein-1 (MT1) in microglia and astrocytes. Conclusion: The beneficial effects of Cu-II(atsm) on the neuroimmune system suggest copper complexes are potential therapeutics for the treatment of neuroinflammatory conditions.Peer reviewe

Science Opportunities offered by Mercury's Ice-Bearing Polar Deposits

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