One-loop Noncommutative U(1) Gauge Theory from Bosonic Worldline Approach

We develop a method to compute the one-loop effective action of noncommutative U(1) gauge theory based on the bosonic worldline formalism, and derive compact expressions for N-point 1PI amplitudes. The method, resembling perturbative string computations, shows that open Wilson lines emerge as a gauge invariant completion of certain terms in the effective action. The terms involving open Wilson lines are of the form reminiscent of closed string exchanges between the states living on the two boundaries of a cylinder. They are also consistent with recent matrix theory analysis and the results from noncommutative scalar field theories with cubic interactions.Comment: 1+35 pages, Latex, address info adde

Supersymmetric Dark Matter and Yukawa Unification

An analysis of supersymmetric dark matter under the Yukawa unification constraint is given. The analysis utilizes the recently discovered region of the parameter space of models with gaugino mass nonuniversalities where large negative supersymmetric corrections to the b quark mass appear to allow $b-\tau$ unification for a positive $\mu$ sign consistent with the $b\to s+\gamma$ and $g_{\mu}-2$ constraints. In the present analysis we use the revised theoretical determination of $a_{\mu}^{SM}$ ($a_{\mu}= (g_{\mu}-2)/2$) in computing the difference $a_{\mu}^{exp}-a_{\mu}^{SM}$ which takes account of a reevaluation of the light by light contribution which has a positive sign. The analysis shows that the region of the parameter space with nonuniversalities of the gaugino masses which allows for unification of Yukawa couplings also contains regions which allow satisfaction of the relic density constraint. Specifically we find that the lightest neutralino mass consistent with the relic density constraint, $b\tau$ unification for SU(5) and $b-t-\tau$ unification for SO(10) in addition to other constraints lies in the region below 80 GeV. An analysis of the maximum and the minimum neutralino-proton scalar cross section for the allowed parameter space including the effect of a new determination of the pion-nucleon sigma term is also given. It is found that the full parameter space for this class of models can be explored in the next generation of proposed dark matter detectors.Comment: 28 pages,nLatex including 5 fig

Microparticles and Nucleosomes Are Released From Parenchymal Cells Destroyed After Injury in a Rat Model of Blunt Trauma

We investigated the relationships between circulating procoagulants and trauma severity, including cellular destruction, and the effects of thrombin generation on procoagulants in a rat blunt trauma model. The rats were subjected to tumbling blunt trauma, where they were tumbled for 0, 250, 500, or 1000 revolutions. Creatine kinase, nucleosome, and microparticle plasma levels increased gradually with trauma severity. Strong interrelationships were observed among creatine kinase, nucleosome, and microparticle levels. Time to initiation of thrombin generation shortened with increasing trauma severity. In accordance with trauma severity, prothrombin activity decreased, but the thrombin generation ratio increased. Time to initiation of thrombin generation and the thrombin generation ratio correlated with creatine kinase levels. In anin vitrostudy, a homogenized muscle solution, which included massive nucleosomes and microparticles, showed accelerated thrombin generation of plasma from healthy subjects. Procoagulants, such as microparticles and nucleosomes, are released from destroyed parenchymal cells immediately after external traumatic force, activating the coagulation cascade. The procoagulants shorten the time to initiation of thrombin generation. Furthermore, although coagulation factors are consumed, the thrombin generation ratio increases

Supernormal Antithrombin Activity Is an Independent Predictor of In-Hospital Mortality in Patients With Sepsis : A Retrospective Observational Study

Supernormal antithrombin (AT) activity is rare in patients with sepsis. This study compared mortality rate of patients with sepsis and supernormal AT activity with that of other patients. This retrospective study included patients with sepsis from 42 intensive care units (ICUs) in Japan. Patients were included if their AT activity was measured on ICU admission, and if they did not receive AT concentrate. They were categorized into low, normal, and supernormal with respective AT activity of 70% to 100%. The primary outcome was hospital in-patient mortality. Nonlinear regression analysis showed that mortality risk gradually increased with AT activity in the supernormal range, but without statistical significance. Survival rate was significantly lower in low (67%) and supernormal (57%) AT groups than in the normal AT group (79%; P < .001 and P = .008, respectively). After adjusting for disease severity and AT activity on day 2, supernormal AT activity was the only independent predictor of mortality. Sepsis with supernormal AT activity associated with high mortality, independent of disease severity, might be a predictor of in-hospital mortality