Evaluation of the relationship between the topographical anatomy in the axillary region of the brachial plexus and the body mass index

WOS: 000439345200023PubMed ID: 28871408To investigate the topographic anatomy of the median, musculocutaneous, radial and ulnar nerves with respect to the axillary artery and to seek whether these configurations are associated with baseline descriptive data including age, gender, and body-mass index. This cross-sectional trial was carried out on 199 patients (85 women, 114 men; average age: 46.78 +/- 15.45 years) in the department of anaesthesiology and reanimation of a tertiary care center. Topographic anatomy of the median, musculocutaneous, radial and ulnar nerves was assessed with ultrasonography. Localization of these nerves with respect to the axillary artery was marked on the map demonstrating 16 zones around the axillary artery. Frequencies of localizations of every nerve in these zones were recorded, and the correlation of these locations with descriptive data including age, gender and BMI was investigated. There was no difference between women and men for the distribution of the median (p = 0.74), ulnar (p = 0.35) and radial (p = 0.64) nerves. However, the musculocutaneous nerve was more commonly located in Zone A13 in men compared to women (p = 0.02). The localization of the median (p = 0.85), ulnar (p = 0.27) and radial (p = 0.88) nerves did not differ remarkably between patients with BMI < 25 kg/m(2) and patients with BMI 25 kg/m(2). Notably, the musculocutaneous nerve was more often determined in Zone A10 in cases with BMI 25 kg/m(2) (p = 0.001). Our results imply that the alignment of the musculocutaneous nerve may vary in men and overweight people. This fact must be considered by the anaesthetist before planning the axillary block of brachial plexus. All these informations may enlighten the planning stages of the brachial plexus blockade

The beneficial effects of ozone therapy in acetaminophen-induced hepatotoxicity in mice

Background: The aim of the present study was to determine the therapeutic effects of medical ozone therapy on acute acetaminophen (APAP)-induced hepatotoxicity which were not clearly demonstrated in prior studies

Histological and electron microscopic examination of the effect of Dexketoprofen Trometamol on liver in rats

WOS: 000413375800008Background: The current study was performed for histological and electron microscopic examination of the effects of different doses of dexketoprofen trometamol on liver in rats. Material and Methods: Shame group consisted of rats administered 1 ml of 0.9% NaCl twice a day via intraperitoneal route, 8 mg/kg/day was used in Dexketoprofen Trometamol low-dose group, and 16 mg/kg/day was used in Dexketoprofen Trometamol high-dose group. 30 healthy Wistar albino type male rats were used in the study as animal materials. Results: The presence of TUNEL positive cells was increased with the increasing dose level of Dexketoprofen Trometamol and TUNEL positive hepatocytes distributed all over the tissue. Diffuse degeneration was determined in the liver sections of the group administered high-dose. Necrotic areas became more apparent particularly in regions close to the central vein. PCNA involvement was detected to be considerably increased compared to the shame and low-dose groups. Electron microscopic image of liver in the group administered high-dose drug showed that all hepatocytes present with highly active cell structure. Hepatocyte mitochondria were observed to be highly developed and to grow large and fuse from place to place. Granulated and smooth endoplasmic reticulum tubulus and cisternae displayed a highly-dilated appearance. Bile canaliculi were distinguished as dilated and its lumen was covered with microvilli. There were many vacuolar formation in addition to lipid droplets in the cytoplasms of ito cells. Conclusion: Dexketroprofen Trometamol drug administration was determined to increase activation particularly in parenchymal cells depending on dose and cause degeneration in liver tissue with heavy activity

Effect of Dexketoprofen Trometamol as Immunohistochemical and Electron Microscopy on Kidney in Rats

WOS: 000452553400004Background and Objective: Dexketoprofen trometamol is the dextrorotatory enantiomer of NSAID ketoprofen formulated as a tromethamine salt. This study aimed to perform immunohistochemical and electron microscopic evaluations of the effects of two different doses of dexketoprofen trometamol on kidneys via parenteral administration for 7 days. Materials and Methods: The study was conducted on 30 healthy, male Wistar albino rats, each weighing approximately 220 g. The rats were randomized and distributed across 3 groups, with 10 rats in each group. In the control group, 0.9% NaCl was used in 1 mL volume. In the other groups, and 16 mg kg(-1)/day doses of dexketoprofen trometamol (Arveles 50 mg/2 mL) in 1 mL were used intraperitoneally twice per day for 7 days. Results: In the high-dose group, a statistically significant reduction in live weight was observed, along with apoptosis and increased cell proliferation when compared to the control group. In the low-dose group, statistically significant increased apoptosis and cell proliferation were found. Conclusion: It was found that dexketoprofen trometamol induced apoptosis and caused cell proliferation and the 16 mg kg(-1)/day dose initiated the necrotic process. When an overdose of dexketoprofen trometamol (16 mg kg(-1)) was administered, losses in live weight and diffuse degeneration of the kidney tissue occurred. Administrations of this dosage are not recommended as similar effects on human tissue are predicted

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

PURPOSE: To assess and compare the histopathological effects of ozone therapy and/or methylprednisolone (MPS) treatment on regeneration after crush type sciatic nerve injury

Evaluation of the relationship between the topographical anatomy in the axillary region of the brachial plexus and the body mass index

WOS: 000439345200023PubMed ID: 28871408To investigate the topographic anatomy of the median, musculocutaneous, radial and ulnar nerves with respect to the axillary artery and to seek whether these configurations are associated with baseline descriptive data including age, gender, and body-mass index. This cross-sectional trial was carried out on 199 patients (85 women, 114 men; average age: 46.78 +/- 15.45 years) in the department of anaesthesiology and reanimation of a tertiary care center. Topographic anatomy of the median, musculocutaneous, radial and ulnar nerves was assessed with ultrasonography. Localization of these nerves with respect to the axillary artery was marked on the map demonstrating 16 zones around the axillary artery. Frequencies of localizations of every nerve in these zones were recorded, and the correlation of these locations with descriptive data including age, gender and BMI was investigated. There was no difference between women and men for the distribution of the median (p = 0.74), ulnar (p = 0.35) and radial (p = 0.64) nerves. However, the musculocutaneous nerve was more commonly located in Zone A13 in men compared to women (p = 0.02). The localization of the median (p = 0.85), ulnar (p = 0.27) and radial (p = 0.88) nerves did not differ remarkably between patients with BMI < 25 kg/m(2) and patients with BMI 25 kg/m(2). Notably, the musculocutaneous nerve was more often determined in Zone A10 in cases with BMI 25 kg/m(2) (p = 0.001). Our results imply that the alignment of the musculocutaneous nerve may vary in men and overweight people. This fact must be considered by the anaesthetist before planning the axillary block of brachial plexus. All these informations may enlighten the planning stages of the brachial plexus blockade