The motives of women Orhan Kemal's stories

Orhan Kemal has an important place in Turkish story writings due to his presence of opposing life and literatüre he high lighted. Orhan Kemal channelling to reader public facts that are approached as person-society links are that wrote with soft wording in his books. He gives message with writing about obstacleand world of absence that common people deal with, and he doesthis as soft and sincerely. In Orhan Kemal‟s stories thereare main persons that wrote with all that their person alities as like as a work holic woman, as a housewife woman, a little girl. He is insipired by the women that lived in his times. The women that Orhan Kemal wrote about; a piece of imbalanced society and a building block for society that dealing with facts and families.Orhan Kemal, hayat ve edebiyat karşısındaki duruşu ve eserlerinde işlediği alışılmışın dışındaki konularıyla Türk hikâyeciliğinde önemli yere sahiptir. Orhan Kemal, eserlerinde toplumsal gerçekleri birey-toplum ilişkileri çerçevesinde ele alıp sade bir dil ile okuyucuya aktarır. Sıradan insanların karşılaştıkları güçlükleri ve yoksunlukla dolu dünyalarını, bireyler üzerinden ele alıp toplumsal mesajlar veren yazar, bunu duru ve samimi bir üslupla yapar. Orhan Kemal hikâyelerinde yakınında yer alan, yaşamın içinde olan kadınlardan esinlenir. Genellikle Orhan Kemal‟in eserlerinde ele aldığı kadınlar; dengesiz bir toplumun parçası ve hayatın gerçekleriyle yüzleşen toplumun ve ailenin yapı taşıdır

Bazı Fenolik Bileşiklerin Yoğunluk Fonksiyonu Yöntemi ile Antioksidan Aktivitelerinin Tayin Edilmesi

Oksidatif stresin başta kanser olmak üzere ateroskleroz, hipertansiyon ve kardiyovasküler hastalıklar gibi pek çok hastalığın patogenezinde rol oynadığı çeşitli araştırmalar sonucunda görülmüştür. Fenolik bileşikler ise insan sağlığı bakımından antioksidan fonksiyonları ile ön plana çıkan maddelerdir. Fenolik antioksidanların serbest radikaller ile reaksiyona girme eğilimi antioksidan aktiviteyi tanımlamaktadır. Bu çalışmada 10 adet fenolik bileşik gaz etanol ve su fazlarında Spartan 14 programı ile DFT//B3LYP metodu ve 6–31+G(d) temel seti ile HAT, SET-PT ve SPLET oksidasyon mekanizmaları gaz, su ve etanol fazlarında modellenmiştir. Elde edilen verilere göre BDE, ETE, PA, IP, PDE ve Δ(EHOMO-ELUMO) değerleri hesaplanarak antioksidan aktiviteleri sıralanmıştır. Yapılan hesaplamalardan elde edilen tüm sonuçlar değerlendirildiğinde bileşik 1 olarak tanımlanan 2-hexadecyl-2,5,7,8-tetramethylchroman-6-ol molekülünün antioksidan aktivitesi çalışılan yöntem ve fazlarda en yüksek olarak bulunmuştur

In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment

Plants have paved the way for the attainment of molecules with a wide-range of biological activities. However, plant products occasionally show low biological activities and/or poor pharmacokinetic properties. In that case, development of their derivatives as drugs from the plant world has been actively performed. As plant products, plastoquinones (PQs) have been of high importance in anticancer drug design and discovery; we have previously evaluated and reported the potential cytotoxic effects of a series of PQ analogs. Among these analogs, PQ2, PQ3 and PQ10 were selected for National Cancer Institute (NCI) for in vitro screening of anticancer activity against a wide range of cancer cell lines. The apparent superior anticancer potency of PQ2 on the HCT-116 colorectal cancer cell line than that of PQ3 and PQ10 compared to other tested cell lines has encouraged us to perform further mechanistic studies to enlighten the mode of anti-colorectal cancer action of PQ2. For this purpose, its apoptotic effects on the HCT-116 cell line, DNA binding capacity and several crucial pharmacokinetic properties were investigated. Initially, MTT assay was conducted for PQ2 at different concentrations against HCT-116 cells. Results indicated that PQ2 exhibited significant cytotoxicity in HCT-116 cells with an IC50 value of 4.97 +/- 1.93 mu M compared to cisplatin (IC50 = 26.65 +/- 7.85 mu M). Moreover, apoptotic effects of PQ2 on HCT-116 cells were investigated by the annexin V/ethidium homodimer III staining method and PQ2 significantly induced apoptosis in HCT-116 cells compared to cisplatin. Based on the potent DNA cleavage capacity of PQ2, molecular docking studies were conducted in the minor groove of the double helix of DNA and PQ2 presented a key hydrogen bonding through its methoxy moiety. Overall, both in vitro and in silico studies indicated that effective, orally bioavailable drug-like PQ2 attracted attention for colorectal cancer treatment. The most important point to emerge from this study is that appropriate derivatization of a plant product leads to unique biologically active compounds

Treatment preferences in stage IA and IB testicular seminoma: Multicenter study of anatolian society of medical oncology

WOS: 000361841900031PubMed ID: 25605506Approximately 75 % of patients with testicular seminoma present with stage I disease, and the probability of long-term survival approaches 100 %. However, the standard adjuvant treatment for stage I seminoma patients remains controversial, and there is no uniform consensus in the literature. The present study was performed to evaluate treatment preference and outcomes for men with stage I testicular seminoma. From 1997 to 2013, 282 patients with histologically confirmed stage IA and IB testicular seminoma who underwent orchiectomy were included. The outcomes of three management options and survivals were retrospectively analyzed. The prognostic significance of risk factors for relapse on survival was evaluated by univariate and multivariate analysis; in addition, the factors predicting relapse were also evaluated by logistic regression analysis. Of the 282 patients with stage I seminoma, 130 (46.1) received adjuvant radiotherapy (RT), 80 (28.4 %) were treated with adjuvant carboplatin, while the remaining 72 patients (25.5 %) underwent surveillance. At the time of analysis, the median follow-up period of 38.5 months; relapses were observed in 16 patients (22.3 %) on surveillance, in one patient (1.2 %) treated with adjuvant carboplatin and in ten patients (%7.7) who received adjuvant RT. The 5-year disease-free survival (DFS) rate for patients who underwent surveillance was worse than those of patients treated with adjuvant carboplatin and RT (64.2 vs. 97.7 vs. 91.9 %, respectively; p < 0.001). However, the 5-year overall survival (OS) rate for patients on surveillance was similar compared with the adjuvant treatment groups (100 vs. 92.3 vs. 97.4 %, respectively; p = 0.44). Univariate analysis showed that only the treatment approach (surveillance vs. adjuvant carboplatin vs. adjuvant RT) for DFS (p < 0.001), invasion of the rete testis (p = 0.041) and the presence of relapse (p < 0.001) for OS were important prognostic indicators. Multivariate analysis indicated that the treatment strategy for DFS (p < 0.001, HR 0.34) was an independent prognostic factor. Furthermore, a logistic regression analysis showed that adjuvant treatment was found to be an independent factor for predicting relapse (p = 0.004, odds ratio: 0.39). Our results indicate that adjuvant treatment with carboplatin or RT is associated with improved DFS compared with surveillance for men with stage I testicular seminoma after orchiectomy. Moreover, the treatment strategy is an important prognostic indicator for DFS and a predictive factor for relapse. Although adjuvant treatment, especially carboplatin, seems to be a suitable treatment for patients with risk factors for relapse, surveillance is still feasible and the preferred management option after radical orchiectomy in men with stage I seminoma. More reliable predictive factors are needed to make treatment decisions