432 research outputs found
Quantifying patient- and hospital-level antimicrobial resistance dynamics in Staphylococcus aureus from routinely collected data.
Introduction. Antimicrobial resistance (AMR) to all antibiotic classes has been found in the pathogen Staphylococcus aureus. The reported prevalence of these resistances varies, driven by within-host AMR evolution at the patient level, and between-host transmission at the hospital level. Without dense longitudinal sampling, pragmatic analysis of AMR dynamics at multiple levels using routine surveillance data is essential to inform control measures.Gap Statement. The value and limitations of routinely collected hospital data to gain insight into AMR dynamics at the hospital and individual levels simultaneously are unclear.Methodology. We explored S. aureus AMR diversity in 70 000 isolates from a UK paediatric hospital between 2000-2021, using electronic datasets containing multiple routinely collected isolates per patient with phenotypic antibiograms and information on hospitalization and antibiotic consumption.Results. At the hospital level, the proportion of isolates that were meticillin-resistant (MRSA) increased between 2014-2020 from 25-50 %, before sharply decreasing to 30%, likely due to a change in inpatient demographics. Temporal trends in the proportion of isolates resistant to different antibiotics were often correlated in MRSA, but independent in meticillin-susceptible S. aureus. Ciprofloxacin resistance in MRSA decreased from 70-40 % of tested isolates between 2007-2020, likely linked to a national policy to reduce fluoroquinolone usage in 2007. At the patient level, we identified frequent AMR diversity, with 4 % of patients ever positive for S. aureus simultaneously carrying, at some point, multiple isolates with different resistances. We detected changes over time in AMR diversity in 3 % of patients ever positive for S. aureus. These changes equally represented gain and loss of resistance.Conclusion. Within this routinely collected dataset, we found that 65 % of changes in resistance within a patient's S. aureus population could not be explained by antibiotic exposure or between-patient transmission of bacteria, suggesting that within-host evolution via frequent gain and loss of AMR genes may be responsible for these changing AMR profiles. Our study highlights the value of exploring existing routine surveillance data to determine underlying mechanisms of AMR. These insights may substantially improve our understanding of the importance of antibiotic exposure variation, and the success of single S. aureus clones
Measurement of the Boson Mass
A measurement of the mass of the boson is presented based on a sample of
5982 decays observed in collisions at
= 1.8~TeV with the D\O\ detector during the 1992--1993 run. From a
fit to the transverse mass spectrum, combined with measurements of the
boson mass, the boson mass is measured to be .Comment: 12 pages, LaTex, style Revtex, including 3 postscript figures
(submitted to PRL
The Azimuthal Decorrelation of Jets Widely Separated in Rapidity
This study reports the first measurement of the azimuthal decorrelation
between jets with pseudorapidity separation up to five units. The data were
accumulated using the D{\O}detector during the 1992--1993 collider run of the
Fermilab Tevatron at 1.8 TeV. These results are compared to
next--to--leading order (NLO) QCD predictions and to two leading--log
approximations (LLA) where the leading--log terms are resummed to all orders in
. The final state jets as predicted by NLO QCD
show less azimuthal decorrelation than the data. The parton showering LLA Monte
Carlo {\small HERWIG} describes the data well; an analytical LLA prediction
based on BFKL resummation shows more decorrelation than the data.Comment: 6 pages with 4 figures, all uuencoded and gzippe
Simulation of the thermally induced austenitic phase transition in NiTi nanoparticles
The reverse martensitic ("austenitic") transformation upon heating of
equiatomic nickel-titanium nanoparticles with diameters between 4 and 17 nm is
analyzed by means of molecular-dynamics simulations with a semi-empirical model
potential. After constructing an appropriate order parameter to distinguish
locally between the monoclinic B19' at low and the cubic B2 structure at high
temperatures, the process of the phase transition is visualized. This shows a
heterogeneous nucleation of austenite at the surface of the particles, which
propagates to the interior by plane sliding, explaining a difference in
austenite start and end temperatures. Their absolute values and dependence on
particle diameter are obtained and related to calculations of the surface
induced size dependence of the difference in free energy between austenite and
martensite.Comment: 6 pages, 4 figures, accepted for publication in "The European
Physical Journal B
Search for Production via Trilepton Final States in collisions at TeV
We have searched for associated production of the lightest chargino,
, and next-to-lightest neutralino, , of the
Minimal Supersymmetric Standard Model in collisions at
\mbox{ = 1.8 TeV} using the \D0 detector at the Fermilab Tevatron
collider. Data corresponding to an integrated luminosity of 12.5 \ipb
were examined for events containing three isolated leptons. No evidence for
pair production was found. Limits on
BrBr are
presented.Comment: 17 pages (13 + 1 page table + 3 pages figures). 3 PostScript figures
will follow in a UUEncoded, gzip'd, tar file. Text in LaTex format. Submitted
to Physical Review Letters. Replace comments - Had to resumbmit version with
EPSF directive
Second Generation Leptoquark Search in p\bar{p} Collisions at = 1.8 TeV
We report on a search for second generation leptoquarks with the D\O\
detector at the Fermilab Tevatron collider at = 1.8 TeV.
This search is based on 12.7 pb of data. Second generation leptoquarks
are assumed to be produced in pairs and to decay into a muon and quark with
branching ratio or to neutrino and quark with branching ratio
. We obtain cross section times branching ratio limits as a function
of leptoquark mass and set a lower limit on the leptoquark mass of 111
GeV/c for and 89 GeV/c for at the 95%\
confidence level.Comment: 18 pages, FERMILAB-PUB-95/185-
Jet Production via Strongly-Interacting Color-Singlet Exchange in Collisions
A study of the particle multiplicity between jets with large rapidity
separation has been performed using the D{\O}detector at the Fermilab Tevatron
Collider operating at TeV. A significant excess of
low-multiplicity events is observed above the expectation for color-exchange
processes. The measured fractional excess is , which is consistent with a strongly-interacting
color-singlet (colorless) exchange process and cannot be explained by
electroweak exchange alone. A lower limit of 0.80% (95% C.L.) is obtained on
the fraction of dijet events with color-singlet exchange, independent of the
rapidity gap survival probability.Comment: 15 pages (REVTeX), 3 PS figs (uuencoded/tar compressed, epsf.sty)
Complete postscript available at http://d0sgi0.fnal.gov/d0pubs/journals.html
Submitted to Physical Review Letter
Measurement of the Atmospheric Muon Charge Ratio at TeV Energies with MINOS
The 5.4 kton MINOS far detector has been taking charge-separated cosmic ray
muon data since the beginning of August, 2003 at a depth of 2070
meters-water-equivalent in the Soudan Underground Laboratory, Minnesota, USA.
The data with both forward and reversed magnetic field running configurations
were combined to minimize systematic errors in the determination of the
underground muon charge ratio. When averaged, two independent analyses find the
charge ratio underground to be 1.374 +/- 0.004 (stat.) +0.012 -0.010(sys.).
Using the map of the Soudan rock overburden, the muon momenta as measured
underground were projected to the corresponding values at the surface in the
energy range 1-7 TeV. Within this range of energies at the surface, the MINOS
data are consistent with the charge ratio being energy independent at the two
standard deviation level. When the MINOS results are compared with measurements
at lower energies, a clear rise in the charge ratio in the energy range 0.3 --
1.0 TeV is apparent. A qualitative model shows that the rise is consistent with
an increasing contribution of kaon decays to the muon charge ratio.Comment: 16 pages, 17 figure
Measurement of neutrino velocity with the MINOS detectors and NuMI neutrino beam
The velocity of a ~3 GeV neutrino beam is measured by comparing detection times at the near and far detectors of the MINOS experiment, separated by 734 km. A total of 473 far detector neutrino events was used to measure (v-c)/c=5.12.910-5 (at 68% C.L.). By correlating the measured energies of 258 charged-current neutrino events to their arrival times at the far detector, a limit is imposed on the neutrino mass of mnu<50 MeV/c2 (99% C.L.)
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