3,450 research outputs found
Minimal kernels of Dirac operators along maps
Let be a closed spin manifold and let be a closed manifold. For maps
and Riemannian metrics on and on , we consider
the Dirac operator of the twisted Dirac bundle . To this Dirac operator one can associate an index
in . If is -dimensional, one gets a lower bound for
the dimension of the kernel of out of this index. We investigate
the question whether this lower bound is obtained for generic tupels
Why genes evolve faster on secondary chromosomes in bacteria
In bacterial genomes composed of more than one chromosome, one replicon is typically larger, harbors more essential genes than the others, and is considered primary. The greater variability of secondary chromosomes among related taxa has led to the theory that they serve as an accessory genome for specific niches or conditions. By this rationale, purifying selection should be weaker on genes on secondary chromosomes because of their reduced necessity or usage. To test this hypothesis we selected bacterial genomes composed of multiple chromosomes from two genera, Burkholderia and Vibrio, and quantified the evolutionary rates (dN and dS) of all orthologs within each genus. Both evolutionary rate parameters were faster among orthologs found on secondary chromosomes than those on the primary chromosome. Further, in every bacterial genome with multiple chromosomes that we studied, genes on secondary chromosomes exhibited significantly weaker codon usage bias than those on primary chromosomes. Faster evolution and reduced codon bias could in turn result from global effects of chromosome position, as genes on secondary chromosomes experience reduced dosage and expression due to their delayed replication, or selection on specific gene attributes. These alternatives were evaluated using orthologs common to genomes with multiple chromosomes and genomes with single chromosomes. Analysis of these ortholog sets suggested that inherently fast-evolving genes tend to be sorted to secondary chromosomes when they arise; however, prolonged evolution on a secondary chromosome further accelerated substitution rates. In summary, secondary chromosomes in bacteria are evolutionary test beds where genes are weakly preserved and evolve more rapidly, likely because they are used less frequently
Recommended from our members
Machine dependence and reproducibility for coupled climate simulations: the HadGEM3-GC3.1 CMIP Preindustrial simulation
When the same weather or climate simulation is run on different high-performance computing (HPC) platforms, model outputs may not be identical for a given initial condition. While the role of HPC platforms in delivering better climate projections is to some extent discussed in the literature, attention is mainly focused on scalability and performance rather than on the impact of machine-dependent processes on the numerical solution.
Here we investigate the behaviour of the Preindustrial (PI) simulation prepared by the UK Met Office for the forthcoming CMIP6 (Coupled Model Intercomparison Project Phase 6) under different computing environments.
Discrepancies between the means of key climate variables were analysed at different timescales, from decadal to centennial. We found that for the two simulations to be statistically indistinguishable, a 200-year averaging period must be used for the analysis of the results. Thus, constant-forcing climate simulations using the HadGEM3-GC3.1 model are reproducible on different HPC platforms provided that a sufficiently long duration of simulation is used.
In regions where El Niño–Southern Oscillation (ENSO) teleconnection patterns were detected, we found large sea surface temperature and sea ice concentration differences on centennial timescales. This indicates that a 100-year constant-forcing climate simulation may not be long enough to adequately capture the internal variability of the HadGEM3-GC3.1 model, despite this being the minimum simulation length recommended by CMIP6 protocols for many MIP (Model Intercomparison Project) experiments.
On the basis of our findings, we recommend a minimum simulation length of 200 years whenever possible
On the Expansions in Spin Foam Cosmology
We discuss the expansions used in spin foam cosmology. We point out that
already at the one vertex level arbitrarily complicated amplitudes contribute,
and discuss the geometric asymptotics of the five simplest ones. We discuss
what type of consistency conditions would be required to control the expansion.
We show that the factorisation of the amplitude originally considered is best
interpreted in topological terms. We then consider the next higher term in the
graph expansion. We demonstrate the tension between the truncation to small
graphs and going to the homogeneous sector, and conclude that it is necessary
to truncate the dynamics as well.Comment: 17 pages, 4 figures, published versio
Potential Benefits on Impairment of Endothelial Function after a High-Fat Meal of 4 Weeks of Flavonoid Supplementation
Studies with foods high in flavonoids have demonstrated improvement in endothelial function. We investigated whether 4 weeks of flavonoid supplementation would prevent an adverse impact on endothelial function of a high-fat meal. Endothelial function was measured by reactive hyperemia peripheral arterial tonometry (RH-PAT). The RH-PAT index was measured both before and 3 h after a high-fat meal, in 23 healthy volunteers. Subjects were randomized in a double-blind, cross-over design to 4 weeks of daily supplementation with OPC-3, or a matching placebo. RH-PAT index before and after the high-fat meal was measured at the beginning and end of each 4-week treatment phase. The high-fat meal caused a decline in endothelial function at baseline in the placebo (-10.71%, P = .006) and flavonoid [-9.97% (P = .077)] groups, and there was no difference in decline between arms (P = .906). The high-fat meal produced a decline after 4 weeks of placebo [-12.37% (P = .005)], but no decline after 4 weeks of flavonoid supplement [-3.16% (P = .663)], and the difference between the two responses was highly significant (P < .0001). Within-group comparisons revealed no difference in endothelial function decline in the placebo arm between baseline and 4 weeks [-10.71% versus -12.37% (P = .758)]. In the flavonoid supplement arm, the difference in endothelial function decline between baseline and 4 weeks was -9.97% versus -3.16%, but did not reach statistical significance (P = .451). These results suggest that the flavonoid supplement used in this study mitigates the impairment of endothelial function caused by a high-fat meal. Whether certain subpopulations derive greater or lesser benefit remains unclear
Permutation combinatorics of worldsheet moduli space
52 pages, 21 figures52 pages, 21 figures; minor corrections, "On the" dropped from title, matches published version52 pages, 21 figures; minor corrections, "On the" dropped from title, matches published versio
Condensation and Polymerization Explain the Humification of Lignin Into Aliphatic and Aromatic Structures in Soil
Soil organic matter (SOM) constitutes a global reservoir of carbon that is more than twice that of either atmospheric carbon or aquatic carbon; however, the manner in which it forms from degraded plant biomass is poorly understood. Some have recently questioned whether plant biomass is involved directly in SOM formation and suggest that it is microbial carbon that constitutes the main source of stable SOM. Such a view implies that above and below ground plant biomass is rapidly decomposed and mineralized. This view contrasts significantly with traditional ones that involve the transformation of plant biomass to recalcitrant humic materials fueled mainly by lignin. One of the main observations for the new viewpoint is that lignin phenols, biomarkers for lignin in plant biomass, become depleted rapidly in SOM and are thought to indicate that lignin, carbohydrates, proteins, and other plant biopolymers are depleted at the same rate.
In the current study we demonstrate that lignin plays a pivotal role in the formation of geologically stable SOM and that the new viewpoint grossly miscalculates the input of microbial biomass. Promoted by the strong oxidation of prevalent reactive oxygen species (ROS) in soil, lignin is not completely mineralized but molecularly transformed to structures not recognizable by lignin phenol biomarker studies. We employ NMR and ultrahigh resolution mass spectrometry on a series of plant biopolymers, synthesized lignin, soil, and peat samples to demonstrate the effect of ROS transformations involving mainly hydroxyl radicals
On globally non-trivial almost-commutative manifolds
Within the framework of Connes' noncommutative geometry, we define and study
globally non-trivial (or topologically non-trivial) almost-commutative
manifolds. In particular, we focus on those almost-commutative manifolds that
lead to a description of a (classical) gauge theory on the underlying base
manifold. Such an almost-commutative manifold is described in terms of a
'principal module', which we build from a principal fibre bundle and a finite
spectral triple. We also define the purely algebraic notion of 'gauge modules',
and show that this yields a proper subclass of the principal modules. We
describe how a principal module leads to the description of a gauge theory, and
we provide two basic yet illustrative examples.Comment: 34 pages, minor revision
Integrable theories and loop spaces: fundamentals, applications and new developments
We review our proposal to generalize the standard two-dimensional flatness
construction of Lax-Zakharov-Shabat to relativistic field theories in d+1
dimensions. The fundamentals from the theory of connections on loop spaces are
presented and clarified. These ideas are exposed using mathematical tools
familiar to physicists. We exhibit recent and new results that relate the
locality of the loop space curvature to the diffeomorphism invariance of the
loop space holonomy. These result are used to show that the holonomy is abelian
if the holonomy is diffeomorphism invariant.
These results justify in part and set the limitations of the local
implementations of the approach which has been worked out in the last decade.
We highlight very interesting applications like the construction and the
solution of an integrable four dimensional field theory with Hopf solitons, and
new integrability conditions which generalize BPS equations to systems such as
Skyrme theories. Applications of these ideas leading to new constructions are
implemented in theories that admit volume preserving diffeomorphisms of the
target space as symmetries. Applications to physically relevant systems like
Yang Mills theories are summarized. We also discuss other possibilities that
have not yet been explored.Comment: 64 pages, 8 figure
Homotopy Theory of Strong and Weak Topological Insulators
We use homotopy theory to extend the notion of strong and weak topological
insulators to the non-stable regime (low numbers of occupied/empty energy
bands). We show that for strong topological insulators in d spatial dimensions
to be "truly d-dimensional", i.e. not realizable by stacking lower-dimensional
insulators, a more restrictive definition of "strong" is required. However,
this does not exclude weak topological insulators from being "truly
d-dimensional", which we demonstrate by an example. Additionally, we prove some
useful technical results, including the homotopy theoretic derivation of the
factorization of invariants over the torus into invariants over spheres in the
stable regime, as well as the rigorous justification of replacing by
and by as is common in the current
literature.Comment: 11 pages, 3 figure
- …