1,744 research outputs found
INVESTIGATION OF THE LOW-SUBSONIC STABILITY AND CONTROL CHARACTERISTICS OF A 0.34 -SCALE FREE-FLYING MODEL OF A MODIFIED HALF-CONE REENTRY VEHICLE
Low subsonic stability and control of a 0.34-scale free flying model of a half cone reentry vehicl
An algorithm for determining program feasibility of a multi-mode PAM commutator telemetry system Technical report no. 10
Algorithm formulation for evaluation of strapping arrangement programs for PAM multimode commutation system of Saturn telemetry syste
Statistical quality control applied to a telemetry system acceptance prodedure Technical report no. 13
Statistical quality control applied to telemetry system acceptance procedur
Analysis of the linearity characteristics, tape recorders and compensation effects in the FM/FM telemetry system
Linearity characteristics, tape recorder effects, and tape speed compensation effects in FM/FM TELEMETRY syste
A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy
BACKGROUND: The efficacy of chemotherapy regimens in breast cancer patients is variable and unpredictable. Whether individual patients either achieve long-term remission or suffer recurrence after therapy may be dictated by intrinsic properties of their breast tumors including genetic lesions and consequent aberrant transcriptional programs. Global gene expression profiling provides a powerful tool to identify such tumor-intrinsic transcriptional programs, whose analyses provide insight into the underlying biology of individual patient tumors. For example, multi-gene expression signatures have been identified that can predict the likelihood of disease reccurrence, and thus guide patient prognosis. Whereas such prognostic signatures are being introduced in the clinical setting, similar signatures that predict sensitivity or resistance to chemotherapy are not currently clinically available. METHODS: We used gene expression profiling to identify genes that were co-expressed with genes whose transcripts encode the protein targets of commonly used chemotherapeutic agents. RESULTS: Here, we present target based expression indices that predict breast tumor response to anthracycline and taxane based chemotherapy. Indeed, these signatures were independently predictive of chemotherapy response after adjusting for standard clinic-pathological variables such as age, grade, and estrogen receptor status in a cohort of 488 breast cancer patients treated with adriamycin and taxotere/taxol. CONCLUSIONS: Importantly, our findings suggest the practicality of developing target based indices that predict response to therapeutics, as well as highlight the possibility of using gene signatures to guide the use of chemotherapy during treatment of breast cancer patients
Vegetable Crops Report: Variety Trials and Cultural Research Test, Muck Crops Branch, 1985
Onion variety trial, 1985 ; Celery variety trial, 1985 ; Broccoli variety trial 1985 ; Row cover evaluation 1985 ; Muskmelons ; Summer squash ; Celery transplants ; Celery seed beds ; Spring broccoli ; Seed quality and seed enhancements on lettuce production 1985 / Richard L. Hassell -- Fertilizer guidelines for vegetable crops grown on muck soils in Ohio / William M. Brooks, E. C. Wittmeyer, and Richard L. Hassel
The Effect of Macro Information Environment Change on the Quality of Management Earnings Forecasts
The 1990s were characterized by substantial increases in the performance of and investor reliance on financial analysts. Because managers possess superior private information and issue forecasts to align investors’ expectations with their own, we predict that managers increased the quality of their earnings forecasts during the 1990s in order to keep pace with the improved forward-looking information provided by financial analysts, upon which investors increasingly relied. Using a sample of 2,437 management earnings forecasts, we document an increase in management earnings forecast precision, management earnings forecast accuracy, and managers’ tendency to explain earnings forecasts in 1993-1996 relative to 1983-1986. Given that these forecast characteristics are linked to greater informativeness and credibility, we also document that the information content of management earnings forecasts, as measured by the strength of share price responses to forecast news, increased in 1993 -1996 relative to 1983-1986. As expected, the increased information content of management forecasts primarily occurred for firms covered by financial analysts
A statistical investigation of the effects contributed by tape recorders and by wow and flutter of magnetic tape on the accuracy of a telemetry system Technical report no. 15
Effects contributed by tape recorders and by wow and flutter of magnetic tape on accuracy of telemetry syste
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