S98RS SGR No. 11 (PAWS Account)

A RESOLUTION To recommend to the Executive Vice Chancellor of Academic Affairs and Provost, Dr. Dan Fogel, and subsequently to the appropriate Faculty Senate Committees to encourage teachers of all 1000-level courses, or below, to have students obtain a PAWS account and perform an assignment requiring use of the Internet

Solitons on compact and noncompact spaces in large noncommutativity

We study solutions at the minima of scalar field potentials for Moyal spaces and torii in the large non-commutativity and interprete these solitons in terms of non-BPS D-branes of string theory. We derive a mass spectrum formula linking different D-branes together on quantum torii and suggest that it describes general systems of D-brane bound states extending the D2-D0 one. Then we propose a shape for the effective potential approaching these quasi-stable bound states. We give the gauge symmetries of these systems of branes and show that they depend on the quantum torii representations.Comment: 25 pages, Latex, 1 figure (use epsfig.sty), corrected formul

Condensed tannin changes along the digestive tract in lambs fed with sainfoin pellets or hazelnut skins

The variable anthelmintic efficacy of condensed tannins (CT) against gastrointestinal nematodes may depend on CT concentration, composition, or fate along the digestive tract. We analyzed CT concentration and composition by acetone−HCl−butanol and thiolysis coupled to HPLC-MS in digesta and feces of lambs. Lambs had been infected with Haemonchus contortus and Trichostrongylus colubriformis and received sainfoin pellets and hazelnut skins of contrasting prodelphinidin/procyanidin ratios. The digesta and feces had lower CT concentrations than the original feeds but similar concentration patterns across the digestive compartments. The changes in assayable CT concentrations between rumen, abomasum, and small intestine may be due to complex formation between CT and other dietary components. However, the large CT disappearance (61−85%) from feed to feces could also indicate that CT may have been structurally modified, degraded, or absorbed during digestion. Interestingly, there were no changes in the structural features of assayable CT in the digesta

Exploratory study of the underutilization of CTSA module services

Background/Objective: The Clinical and Translational Science Award (CTSA) program aims to enhance the quality, efficiency, and impact of translation from discovery to interventions that improve human health. CTSA program hubs at medical research institutions across the United States develop and test innovative tools, methods, and processes, offering core resources and training for the clinical and translational research (CTR) workforce. Hubs have developed services across different domains, such as informatics and pilot studies, to provide ad hoc expertise and staffing for local research teams. Although these services can provide efficient, cost-effective ways to cover skills gaps and implement rigorous studies, three CTSAs of varying size found the majority of investigators were single domain service users, likely missing opportunities to further enhance their work. Methods: Through interviews with CTSA service users and a survey of CTSA service managers, this exploratory study aims to identify barriers to using services from multiple modules and solutions to overcome those barriers. Results: Barriers include challenges in finding information about services, unclear or unknown user needs, and users’ lack of funding to engage in services. More issues were identified for the largest CTSA. Conclusions: Although this study represents a small subset of CTSA hubs, we anticipate that our findings and proposed solutions will be relevant to the broader CTSA community. This study provides foundational information can use in their own efforts to increase service utilization and methods that can be used for more comprehensive studies that focus on explaining the relationship between CTSA features and rates of single versus cross-module service use.Peer Reviewe

Stable, Ductile and Strong Ultrafine HT-9 Steels via Large Strain Machining

Beyond the current commercial materials, refining the grain size is among the proposed strategies to manufacture resilient materials for industrial applications demanding high resistance to severe environments. Here, large strain machining (LSM) was used to manufacture nanostructured HT-9 steel with enhanced thermal stability, mechanical properties, and ductility. Nanocrystalline HT-9 steels with different aspect rations are achieved. In-situ transmission electron microscopy annealing experiments demonstrated that the nanocrystalline grains have excellent thermal stability up to 700 & DEG;C with no additional elemental segregation on the grain boundaries other than the initial carbides, attributing the thermal stability of the LSM materials to the low dislocation densities and strains in the final microstructure. Nano-indentation and micro-tensile testing performed on the LSM material pre- and post-annealing demonstrated the possibility of tuning the material's strength and ductility. The results expound on the possibility of manufacturing controlled nanocrystalline materials via a scalable and cost-effective method, albeit with additional fundamental understanding of the resultant morphology dependence on the LSM conditions

Effect of vitamin D replacement on maternal and neonatal outcomes: a randomised controlled trial in pregnant women with hypovitaminosis D. A protocol

Introduction: The vitamin D recommended doses during pregnancy differ between societies. The WHO guidelines do not recommend routine prenatal supplementation, but they underscore the fact that women with the lowest levels may benefit most. The effects of routine supplementation during pregnancy on maternal and neonatal clinical outcomes have not been investigated in the Middle East, where hypovitaminosis D is prevalent. Our hypothesis is that in Middle Eastern pregnant women, a vitamin D dose of 3000?IU/day is required to reach a desirable maternal 25-hydroxyvitamin D [25(OH)D] level, and to positively impact infant bone mineral content (BMC).Methods and analysis: This is a multicentre blinded randomised controlled trial. Pregnant women presenting to the Obstetrics and Gynaecology clinics will be approached. Eligible women will be randomised to daily equivalent doses of cholecalciferol, 600?IU or 3000?IU, from 15 to 18?weeks gestation until delivery. Maternal 25(OH)D and chemistries will be assessed at study entry, during the third trimester and at delivery. Neonatal anthropometric variables and 25(OH)D level will be measured at birth, and bone and fat mass assessment by dual-energy X-ray absorptiometry scan at 1?month. A sample size of 280 pregnant women is needed to demonstrate a statistically significant difference in the proportion of women reaching a 25(OH)D level ?50?nmol/L at delivery, and a difference in infant BMC of 6 (10)g, for a 90% power and a 2.5% level of significance. The proportions of women achieving a target 25(OH)D level will be compared between the two arms, using ?2. An independent t test will be used to compare mean infant BMC between the two arms. The primary analysis is an intention-to-treat analysis of unadjusted results.Ethics and dissemination: The protocol has been approved by the Institutional Review Board at the American University of Beirut-Lebanon (IM.GEHF.22). The trial results will be published in peer-reviewed medical journals and presented at scientific conferences.Trial registration number: NCT02434380.<br/

String compactifications on Calabi-Yau stacks

In this paper we study string compactifications on Deligne-Mumford stacks. The basic idea is that all such stacks have presentations to which one can associate gauged sigma models, where the group gauged need be neither finite nor effectively-acting. Such presentations are not unique, and lead to physically distinct gauged sigma models; stacks classify universality classes of gauged sigma models, not gauged sigma models themselves. We begin by defining and justifying a notion of ``Calabi-Yau stack,'' recall how one defines sigma models on (presentations of) stacks, and calculate of physical properties of such sigma models, such as closed and open string spectra. We describe how the boundary states in the open string B model on a Calabi-Yau stack are counted by derived categories of coherent sheaves on the stack. Along the way, we describe numerous tests that IR physics is presentation-independent, justifying the claim that stacks classify universality classes. String orbifolds are one special case of these compactifications, a subject which has proven controversial in the past; however we resolve the objections to this description of which we are aware. In particular, we discuss the apparent mismatch between stack moduli and physical moduli, and how that discrepancy is resolved.Comment: 85 pages, LaTeX; v2: typos fixe