Coherent vibrations of submicron spherical gold shells in a photonic crystal

Coherent acoustic radial oscillations of thin spherical gold shells of submicron diameter excited by an ultrashort optical pulse are observed in the form of pronounced modulations of the transient reflectivity on a subnanosecond time scale. Strong acousto-optical coupling in a photonic crystal enhances the modulation of the transient reflectivity up to 4%. The frequency of these oscillations is demonstrated to be in good agreement with Lamb theory of free gold shells.Comment: Error in Eqs.2 and 3 corrected; Tabl. I corrected; Fig.1 revised; a model that explains the dependence of the oscillation amplitude of the transient reflectivity with wavelength adde

Low-Reynolds-number gravity-driven migration and deformation of bubbles near a free surface

International audienceWe investigate numerically the axisymmetric migration of bubbles toward a free surface, using a boundary-integral technique. Our careful numerical implementation allows to study the bubble(s) deformation and film drainage; it is benchmarked against several tests. The rise of one bubble toward a free surface is studied and the computed bubble shape compared with the results of Princen [J. Colloid Interface Sci. 18, 178 (1963)]. The liquid film between the bubble and the free surface is found to drain exponentially in time in full agreement with the experimental work of Debre'geas et al. [Science 279, 1704 (1998)]. Our numerical results also cast some light on the role played by the deformation of the fluid interfaces and it turns out that for weakly deformed interfaces (high surface tension or a tiny bubble) the film drainage is faster than for a large fluid deformation. By introducing one or two additional bubble(s) below the first one, we examine to which extent the previous trends are affected by bubble-bubble interactions. For instance, for a 2-bubble chain, decreasing the bubblebubble separation increases the deformation of the last bubble in the chain. Finally, the exponential drainage of the film between the free surface and the closest bubble is preserved, yet the drainage is enhanced

A transdiagnostic systematic review and meta-analysis of ketamine's anxiolytic effects

Background:Ketamine may be effective in treating symptoms of anxiety, but the time profile of ketamine’s anxiolytic effect is ill-defined. This systematic review and meta-analysis investigated the anxiolytic effect of ketamine at different time points across a range of clinical settings.Methods:Electronic databases were searched to capture randomised control trials measuring the anxiolytic effects of ketamine in contexts including mood disorders, anxiety disorders and chronic pain. Meta-analyses were conducted using a random-effects model. The correlations between (1) improvements in mean anxiety and depression scores, and (2) peak dissociation and improvements in mean anxiety scores were also assessed.Results:In all, 14 studies met inclusion criteria. Risk of bias was high in 11 studies. Ketamine significantly reduced anxiety scores compared to placebo at acute (<12 h; standard mean difference (SMD): −1.17, 95% confidence interval (CI) [−1.89, −0.44], p < 0.01), subacute (24 h; SMD: −0.44, 95% CI [−0.65, −0.22], p < 0.01) and sustained (7–14 days; SMD: −0.40, 95% CI [−0.63, −0.17], p < 0.01) time points. Exploratory analyses revealed improvements in anxiety and depression symptoms correlated at both subacute (R2 = 0.621, p = 0.035) and sustained time points (R2 = 0.773, p = 0.021). The relationship between peak dissociation and improvement in anxiety was not significant.Conclusions:Ketamine appears to offer rapid and sustained anxiety symptom relief across a range of clinical settings, with anxiolytic effects occurring within the first 12 h of administration and remaining effective for 1–2 weeks. Future studies could explore the effects of ketamine maintenance therapy on anxiety symptoms

Siting prisons, sighting communities: geographies of objection in a planning process

This paper reviews the planning process for a Scottish prison located near a former mining village. Analysing the letters of objection submitted by residents offers an opportunity to explore local views about prison and community and to relate these to the unique social and spatial history of the area. The planning process itself structured how residents were able to express themselves and defined what counted as a relevant objection. After deconstructing this process, the paper then restores and uses as a framework for analysis three geographies of objection stripped from local responses to the development proposal: the emotional, temporal, and spatial. Emotional expressions of objection added intensity and gave meaning to claims about the historical decline of the region and also conveyed a deep sense of the proposed building site as a lived space. Particular grounds of opposition—over fear of strangers, the fragility of a local orchid, and the pollution from mining—provide an opportunity to explore the complex nature of place meaning and community identity, ultimately leading to a conclusion that the meaning of place is always in flux. The paper argues that Simmel’s classic concept of the stranger, as the outsider who comes to stay, offers a useful analytic in understanding how the quality of proximal remoteness that prisons and other unwanted developments constitute participates in a constantly evolving sense of the local

Seasonal Shifts in Jumping Patterns: A Study of Countermovement Jump Strategies in High School Football Athletes

Modern sporting trends have begun to adopt sport science and load monitoring to identify in-season trends with the goal of improving performance and reducing injury. Although these resources have become increasingly common in professional and collegiate sports, many high school athletic programs have yet to adopt such technologies. While previous research has demonstrated season-long changes in jump performance, no research has investigated the impact of in-season demands on the changes in jump strategy in male high school football athletes. PURPOSE: The purpose of this study was to examine changes in jump strategy in high school football players over a single football season. METHODS: Sixty-nine male high school football athletes, including 25 offensive skill, 23 linemen, 12 linebackers, 7 defensive backs, and 2 special teams players were tested for maximal jump performance at the beginning and end of a high school football season. Testing was conducted using three attempts of a maximal hands-on-hips countermovement jump on portable force plates, with the average of the three jumps used for analysis. A minimum of 10-weeks between sessions accounted for the time between pre- and post-testing. A dependent-samples t-test was performed to calculate differences between the two time points. RESULTS: Significant reductions were observed across all phases of the jump movement revealed significant differences from pre- to post- testing. The largest reduction was seen during the unweighting phase (0.40 to 0.36s), followed by braking phase (0.22 to 0.19s), and finally propulsive phase (0.30 to 0.28s). Resulting in a total time to takeoff decrease of 0.92 seconds to 0.83 seconds, resulting in an increase in mean jump height (14.15 to 14.89 inches). Jump strategy differences were also significantly different between time points for modified reactive strength index (0.40 to 0.47 and stiffness metrics (-4996.86 to -5622.46N/m). No differences were seen for countermovement depth (t(68) = 0.44, p=0.663) between the two time points. CONCLUSION: At the end of a competitive season, high school football athletes increased their speed at all phases of the jumping motion. Despite the increased speed during the movement, there were no changes in the countermovement depth prior to takeoff. Our research indicates that football athletes become faster and more efficient with their CMJ strategy to achieve increased performance as measured by Jump Height. Future studies may benefit from collecting follow-up data collection to examine the detraining effect that can occur post-competition, and to incorporate differences between double and single leg jumping strategy. Doing so has the potential to identify injury risk and asymmetries throughout the season

Countermovement Jump Performance Trends in High School Football Players Throughout a Competitive Season

Football is the largest participation sport amongst male high school athletes in the country with over one million participants. Previous research has demonstrated that countermovement jump (CMJ) performance is negatively affected by in-season fatigue in contact sports such as rugby and hockey. However, little data are available to describe how CMJ performance and force metrics change in high school athletes throughout a competitive football season. PURPOSE: The purpose of this study was to examine the changes in strength and power metrics in high school football players over a single football season. METHODS: Sixty-nine male high school football athletes comprised of 25 offensive skill players, 23 linemen, 12 linebackers 7 defensive backs, and 2 special teams players were tested for maximal lower body force output at the beginning and end of a high school football season. Testing was conducted using three attempts of a maximal hands-on-hips countermovement jump on portable force plates, with the average of the three jumps used for analysis. Pre-testing occurred prior to the first game of the season, and post-test was conducted after the final game of the season with a minimum of 10-weeks between sessions accounted for the time between pre- and post-testing. A dependent-samples t-test was performed to calculate differences between the two time points. RESULTS: Significant improvements in jump height (14.15 to 14.89 inches), relative force at minimum displacement (220.36 to 235.77% body weight), peak relative braking force (220.72 to 236.39% body weight), peak relative propulsive force (238.07 to 248.02% body weight), peak braking velocity (-1.17 to -1.30m/s), and takeoff velocity (2.64 to 2.71m/s). No significant differences were seen in relative peak landing force (t(68) = 0.53, p=0.600). CONCLUSION: At the end of a competitive season, high school football athletes produced more force and increased their movement velocity, resulting in improvements in jump height compared to the beginning of the season. However, there were no significant differences in landing metrics indicating no changes in force absorption capacity. These increases in jump performance do not reflect results previously reported in contact sports such as rugby and hockey where jump performance typically decreased over the course of a season. Future studies may benefit from collecting additional performance data to assess the impact seasonal fatigue has on other body systems separate to lower body power production, and the effect to which practice and strength and conditioning programming impact force metrics. Without appropriate monitoring strategies, coaches are leaving the assessment of load management to chance, which can potentially lead to decreased performance and an increased chance of injury

Condensation corrosion alters the oxygen and carbon isotope ratios of speleothem and limestone surfaces

Condensation corrosion is a natural process which enhances the chemical weathering of limestone cave chambers and speleothems. We evaluated the use of carbonate tablets for detecting condensation corrosion in Glowworm Cave, New Zealand, using local limestone and speleothem as experimental substrates (herein tablets). Evidence for condensation corrosion was assessed via three methods: gravimetric (mass wasting), microscopic (surface pitting, recrystallization) and isotopic (δ¹³C and δ¹⁸O changes). Our results show little evidence of tablet mass loss throughout a 6-month deployment period. However, SEM imaging and isotope analysis (δ¹³C and δ¹⁸O) of the upper ∼50 μm layer of the tablets, suggest that condensation corrosion operates in the cave, especially in sectors affected by large diurnal microclimate variations. Most notably, condensation water altered the tablet surface δ¹³C and δ¹⁸O values. Small, positive shifts in surface δ¹³C and δ¹⁸O values are considered to reflect pure dissolution (where dissolution favours the removal of lighter isotopologues). In contrast, tablets that exhibited large positive shifts in δ¹³C in tandem with large negative shifts in δ¹⁸O values, are interpreted as showing calcite recrystallization and the inheritance of higher DIC δ¹³C values (¹³C fractionation by CO₂ degassing), lighter water δ¹⁸O values and/or kinetic fractionation of δ¹⁸O. This study therefore demonstrates that stable isotopes could be applied to detect paleoclimatic episodes of condensation corrosion in speleothems

Local and Regional Indian Summer Monsoon Precipitation Dynamics During Termination II and the Last Interglacial

To date Indian summer monsoon (ISM) dynamics have been assessed by changes in stalagmite δ18O. However, stalagmite δ18O is influenced by multiple environmental factors (e.g., atmospheric moisture transport, rainfall amount at the study site, and ISM seasonality), precluding simple and clear reconstructions of rainfall amount or variability. This study aims to disentangle these environmental factors by combining δ18O, δ44Ca, and elemental data from a stalagmite covering Termination II and the last interglacial from Mawmluh Cave, NE India, to produce a semiquantitative reconstruction of past ISM rainfall. We interpret δ18O as a mixed signal of rainfall source dynamics and rainfall amount and coupled δ44Ca and X/Ca ratios as indicators of local infiltration rate and prior calcite precipitation in the karst zone. The wettest conditions in our studied interval (135 and 100 kyrs BP; BP = before present, with the present being 1950 CE) occurred during Marine Isotope Stage 5e. Our multiproxy data set suggests a likely change in seasonal distribution of Marine Isotope Stage 5e rainfall compared to the Holocene; the wet season was longer with higher‐than‐modern dry season rainfall. Using the last interglacial as an analogue for future anthropogenic warming, our data suggest a more erratic ISM behavior in a warmer world

Genetic Diversity and Virulence Potential of Shiga Toxin-Producing Escherichia coli O113:H21 Strains Isolated from Clinical, Environmental, and Food Sources

Shiga toxin-producing Escherichia coli strains of serotype O113:H21 have caused severe human diseases, but they are unusual in that they do not produce adherence factors coded by the locus of enterocyte effacement. Here, a PCR microarray was used to characterize 65 O113:H21 strains isolated from the environment, food, and clinical infections from various countries. in comparison to the pathogenic strains that were implicated in hemolytic-uremic syndrome in Australia, there were no clear differences between the pathogens and the environmental strains with respect to the 41 genetic markers tested. Furthermore, all of the strains carried only Shiga toxin subtypes associated with human infections, suggesting that the environmental strains have the potential to cause disease. Most of the O113:H21 strains were closely related and belonged in the same clonal group (ST-223), but CRISPR analysis showed a great degree of genetic diversity among the O113:H21 strains.French Joint Ministerial Program of R&D against CBRNE RisksFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Food & Drug Adm, Div Microbiol, College Pk, MD 20740 USAFrench Agcy Food Environm & Occupat Hlth & Safety, Lab Food Safety, Maisons Alfort, FranceFood & Drug Adm, Div Mol Biol, Laurel, MD USAUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, BrazilFed Inst Risk Assessment, Natl Reference Lab Escherichia coli, Berlin, GermanyInst Nacl Enfermedades Infecciosas ANLIS Dr Carlo, Serv Fisiopatogenia, Buenos Aires, DF, ArgentinaUniv Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic, AustraliaUniv Adelaide, Res Ctr Infect Dis, Sch Mol & Biomed Sci, Adelaide, SA, AustraliaUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, BrazilFrench Joint Ministerial Program of R&D against CBRNE Risks: C17609-2Web of Scienc

The single-cell pathology landscape of breast cancer.

Single-cell analyses have revealed extensive heterogeneity between and within human tumours1-4, but complex single-cell phenotypes and their spatial context are not at present reflected in the histological stratification that is the foundation of many clinical decisions. Here we use imaging mass cytometry5 to simultaneously quantify 35 biomarkers, resulting in 720 high-dimensional pathology images of tumour tissue from 352 patients with breast cancer, with long-term survival data available for 281 patients. Spatially resolved, single-cell analysis identified the phenotypes of tumour and stromal single cells, their organization and their heterogeneity, and enabled the cellular architecture of breast cancer tissue to be characterized on the basis of cellular composition and tissue organization. Our analysis reveals multicellular features of the tumour microenvironment and novel subgroups of breast cancer that are associated with distinct clinical outcomes. Thus, spatially resolved, single-cell analysis can characterize intratumour phenotypic heterogeneity in a disease-relevant manner, with the potential to inform patient-specific diagnosis