Relevansi Peraturan Dalam Mendukung Praktek Profesi Apoteker Di Apotek

One of pharmacy’s duty is being the place of pharmacist to serve patient profesionally.The fact, it was many report in mass media that pharmacist ‘s performance is not good enough. Many pharmacy regulation already issued, this review report and discuss pharmacy regulations related to pharmacy. Regulation that have issued by goverment about pharmacy ie: St. No.419 in 1949, Goverment regulations (PP) No.25 in 1980, Rule of Minister of Health (Permenkes) No.26 in 1981, Kepmenkes No. 278, 279 and 280 in 1981, Permenkes No.240 in 1990, Kepmenkes No.347 in 1990, Permenkes No.922 in 1993, Act (UU) No.5 in 1997, UU No.22 in 1997, PP No.72 in 1998, UU No.8 in 1999, Kepmenkes No.1332 in 2002, UU No.29 in 2004, Kepmenkes No.1027 in 2004, and Permenkes No.384 in 2007. Pharmacyregulations are enouh and relevance to support pharmacist practice, commitment to adhere the regulations and enforcement its implementation still required

RELEVANSI PERATURAN DALAM MENDUKUNG PRAKTEK PROFESI APOTEKER DI APOTEK

One of pharmacy’s duty is being the place of pharmacist to serve patient profesionally.The fact, it was many report in mass media that pharmacist ‘s performance is not good enough. Many pharmacy regulation already issued, this review report and discuss pharmacy regulations related to pharmacy. Regulation that have issued by goverment about pharmacy ie: St. No.419 in 1949, Goverment regulations (PP) No.25 in 1980, Rule of Minister of Health (Permenkes) No.26 in 1981, Kepmenkes No. 278, 279 and 280 in 1981, Permenkes No.240 in 1990, Kepmenkes No.347 in 1990, Permenkes No.922 in 1993, Act (UU) No.5 in 1997, UU No.22 in 1997, PP No.72 in 1998, UU No.8 in 1999, Kepmenkes No.1332 in 2002, UU No.29 in 2004, Kepmenkes No.1027 in 2004, and Permenkes No.384 in 2007. Pharmacyregulations are enouh and relevance to support pharmacist practice, commitment to adhere the regulations and enforcement its implementation still required.Key words : regulation, pharmaceutical care, pharmacy

Director's Report for the Seven Months--December 1, 1942 - June 30, 1943

Red ginger (Zingiber officinale var. rubrum) has been proven to show anticancer activity. Direct use bioactive compound from red ginger has many obstacles such as large amount of red ginger’s rhizome needed, limitation of planting area, and very long time of harvesting. Utilization of endophytic fungi from red ginger’s rhizome could be an alternative to the problems. The aims of this study were to determine bioactive compound produced by endophytic fungi and toxicity activity based on LC50. Endophytic fungi were isolated from red ginger and were identified macroscopically and microscopically. The bioactive compounds were extracted using ethanol 96%. Flavonoid test was done qualitatively, bioactive compounds were analyzed by Thin Layer Chromatography (TLC), and the toxicity test was done using Brine Shrimp Lethality Assay (BSLA). The present research found two endophytic fungi isolated from red ginger rhizome. Isolate 1 was similar to Mucor sp. and isolate 2 was similar to Trichoderma sp. Phytochemical test revealed bioactive compound extracted from the isolates were contained flavonoid. TLC analysis did not detect quercetin from the bioactive compound extracted from the isolates. LC50 values of the bioactive compound from the isolates were 2.300 and 1.747 µg/ml, respectively. The toxicological results suggest that both isolates produce non-toxic compound to Artemia salina

Isolasi dan identifikasi senyawa antimikroba dari lantana camara l.=Isolation and Identification Antimicrobial Compound fromLantana Camara L.

ABSTRACT The isolation and identification of antimicrobial compound from the aerial parts of Lantana camara L". plant has been carried out. The isolation was started by maceration of the the aerial parts of Lantana camara L. plants with chloroform (CHQ3), then remacerated with methanol (MeOH). Both extracts were tested for their antimicrobial activity using agar dilution method. The active extract was then extracted with aceton, followed by microbial activity and the active fraction was then refractinated with 80% MeOH, followed by microbial activity test. The active fractions were then defractinated using vacuum liquid cnromatography (VLC). The fractions were tested for their antimicrobial activity using agar dilution method, followed by bioautogra-phy method. Active spot was then isolated using preparatif TLC. The minimal bactericidal consentration (MBC) value of isolate (LC^), was determined using agar dilution method. Structure elucidation of active compound was established based on the spectra of ultra violet (UV), infra red (IR), mass spectra (MS), nuclear magnetic resonance (NMR)13C, NMR1^ correlation spectroscopy (COSY) and heteronuclear correlation (HETCOR). The U V spectra of isolate (LCOT), showed the maximum absorbance (1) at 241 nm. The IR spectra showed the wavenumber (n) at 3448 cm1 (OH), 2918 cm1, 2850 cnr1 (CH3 CH2 alifatik), 1718 cm1 (CO dari COOH) dan 1637 cm 1(C=C). High resolution electrospray ionization showed molecular ion m/z 470 (CJ-I OJ. The NMR13C spectra at 100 MHz showed 35 absorbance (35 C), 178ppm (COOH), 165,5 ppm (C=O ester), 122,5 ppm, 143 ppm (the oleanilic families,b-amirin skeleton). Based on UV, IR, MS, and NMR"C, identification of isolate LQ, seems to be a compound that have olean type, b-amirin skeleton, with ester of carboxilic acid. The NMR^ spectra at 400 MHz showed 8 sharp singlet absorbances (8 methyl singlets), and absorbance at 5,56 ppm (atom H at C^). Based on the spectrum and comparation with literature study, and ensure with COSY and HETCOR spectrum, it can be concluded that the aktif compound is lantanilic acid. Based on the antimicrobial activity test of isolate (LCm), Lantana camara L. plant contains lantanilic acid, that be able to kill the growth of Staphylococcus aureus at the concentration of 375 mg/ml. Keywords : Antimicrobial â Lantana camara I. â and Lantanilic acid