Incomplete sex chromosome dosage compensation in the Indian meal moth, Plodia interpunctella, based on de novo transcriptome assembly.

Journal ArticleResearch Support, Non-U.S. Gov'tMales and females experience differences in gene dose for loci in the nonrecombining region of heteromorphic sex chromosomes. If not compensated, this leads to expression imbalances, with the homogametic sex on average exhibiting greater expression due to the doubled gene dose. Many organisms with heteromorphic sex chromosomes display global dosage compensation mechanisms, which equalize gene expression levels between the sexes. However, birds and Schistosoma have been previously shown to lack chromosome-wide dosage compensation mechanisms, and the status in other female heterogametic taxa including Lepidoptera remains unresolved. To further our understanding of dosage compensation in female heterogametic taxa and to resolve its status in the lepidopterans, we assessed the Indian meal moth, Plodia interpunctella. As P. interpunctella lacks a complete reference genome, we conducted de novo transcriptome assembly combined with orthologous genomic location prediction from the related silkworm genome, Bombyx mori, to compare Z-linked and autosomal gene expression levels for each sex. We demonstrate that P. interpunctella lacks complete Z chromosome dosage compensation, female Z-linked genes having just over half the expression level of males and autosomal genes. This finding suggests that the Lepidoptera and possibly all female heterogametic taxa lack global dosage compensation, although more species will need to be sampled to confirm this assertion.Royal Society Wolfson AwardEuropean Research Council Framework

Gingival Crevicular Flow (Volume) as a Biomarker of Orthodontic Tooth Movement

Tooth movement is caused by the application of force. In short, applied force strains structures present in the PDL space – cells, ligaments, blood vessels. Cells in the PDL are damaged by extension and by diminished oxygen supply due to compression of blood vessels. Compounds released from damaged or dead cells trigger an innate inflammatory response. One of the biomarkers of that response is increased formation of extracellular fluid (edema), specifically gingival crevicular fluid (GCF). Our goal is to monitor changes of GCF flow during the orthodontic treatment with Invisalign

Case 8 : Camp fYrefly

Since its founding in 2004, Camp fYrefly has become Canada’s only national leadership retreat for sexual and gender minority (SGM) youth. The camp has expanded to include two successful locations in Alberta (Edmonton and Calgary), and one in Saskatchewan (either Regina or Saskatoon, alternating annually). The main focus of Camp fYrefly is building leadership capacity and personal resiliency in campers. 2017 is the planned inaugural summer for Camp fYrefly to expand to Peterborough in Ontario. In addition to maintaining Camp fYrefly’s original mission of building resilience and leadership capacity, the Ontario camp director hopes to integrate a holistic approach to health within camp programming

Migrant translation tool

This was a presentation at Inspire outlining how we developed a migrant translation tool to assist the target population with communication barriers and to make medical services more accessible (and better understood). The migrant tool promotes a culturally sensitive approach to communication with speakers of other languages in a medical context

Does Autism Affect Children’s Identification of Ownership and Defence of Ownership Rights?

open access articleThis study investigated how autism spectrum disorder (ASD) impacts children’s ability to identify ownership from linguistic cues (proper nouns vs. possessive pronouns) and their awareness of ownership rights. In comparison to typically developing (TD) children matched on receptive language (M age equivalents: 53–56 months), children with ASD were less accurate at tracking owner-object relationships based on possessive pronouns and were less accurate at identifying the property of third parties. We also found that children with ASD were less likely to defend their own and others’ ownership rights. We hypothesise that these results may be attributed to differences in representing the self and propose that ASD may be characterised by reduced concern for ownership and associated concepts

The utility of modified Butler-Leggett criteria for right ventricular hypertrophy in detection of clinically significant shunt ratio in ostium secundum-type atrial septal defect in adults

Background: This study was performed to test the hypothesis that there exists a correlation between the Butler-Leggett (BL) criterion for right ventricular hypertrophy on the electrocardiogram and the Qp/Qs shunt ratio in adults with ostium secundum atrial septal defects (ASDs). Methods: Demographic, cardiac catheterization, ASD closure, and electrocardiographic data were acquired on 70 patients with secundum ASDs closed percutaneously. Simple linear regression and logistic regression models were created to test the hypothesis. Results: The mean Qp/Qs ratio and BL criterion value were 1.61 +/- 0.46 and 0.11 +/- 0.41, respectively. The BL criterion values correlated with shunt ratios (r(2) = 0.11 and P = .004). A BL criterion value greater than 0 mV predicted a significant shunt ratio (Qp/Qs \u3e or = 1.5) (odds ratio, 4.8; 95% confidence interval, 1.3, 18.1; P = or \u3c.0001) with a sensitivity of 0.68 and specificity of 0.65. Conclusion: Our results indicate that there is limited utility of the BL criterion at detecting right ventricular volume overload, although a BL criterion value greater than 0 mV being used to identify patients with significant intracardiac shunts yielded a sensitivity of 0.68 and specificity of 0.65

Meteorological training for the digital age: A Blueprint for a new curriculum

Almost all professional meteorologists take part in meteorological training during their undergraduate or graduate study or professional job training in the public or private sector. Increased benefits can be accrued by employers and employees, if this training is based on the same underpinning skills and attributes, aimed to equip people entering meteorology for the wide range of future roles they might undertake. While there is a great deal of excellent, innovative practice in our community, the time is now right to look again at the nature of the meteorological curriculum. Meteorology faces significant challenges in the 21st century to deal with the twin challenges of increases in the number and severity of extreme weather events and the increased complexity of forecasts demanded by end-users. Here, a blueprint which describes a number of key principles which should be used to design, evaluate and enhance curricula for students entering our field in the next 10 years is proposed. The blueprint does not discuss in detail the core mathematical and physical principles which underlie any high quality training in meteorology but rather focuses on the key skills and attributes needed to make the next-generation of meteorologists innovative and effective which include: • Meteorological competencies, • Personal and inter-personal attributes, • Core skills as a scientist and • Ethical and professional interaction with broader society. The blueprint is intended to encourage debate about how we equip new meteorologists for the digital age. We plan to use these principles to review and enhance our own curricula in the near future

Predictors of Indoor Air Concentrations in Smoking and Non-Smoking Residences

Indoor concentrations of air pollutants (benzene, toluene, formaldehyde, acetaldehyde, acrolein, nitrogen dioxide, particulate matter, elemental carbon and ozone) were measured in residences in Regina, Saskatchewan, Canada. Data were collected in 106 homes in winter and 111 homes in summer of 2007, with 71 homes participating in both seasons. In addition, data for relative humidity, temperature, air exchange rates, housing characteristics and occupants’ activities during sampling were collected. Multiple linear regression analysis was used to construct season-specific models for the air pollutants. Where smoking was a major contributor to indoor concentrations, separate models were constructed for all homes and for those homes with no cigarette smoke exposure. The housing characteristics and occupants’ activities investigated in this study explained between 11% and 53% of the variability in indoor air pollutant concentrations, with ventilation, age of home and attached garage being important predictors for many pollutants

An Ethical Framework for Library Publishing: Version 0.5 (Draft for Comment)

Background: At the Library Publishing Coalition (LPC) Membership Meeting at the 2017 Library Publishing Forum in Baltimore, Maryland, the community discussed how the LPC can respond to the current political climate. The discussion was wide-ranging, but kept coming back to the importance of library values and our responsibility as library publishers to center our publishing practice around them. A number of those present offered to devise a way for the conversation to continue beyond the Forum. That group included Marilyn Billings, Jason Boczar, Rebel Cummings-Sauls, Harrison W. Inefuku, Joshua Neds-Fox, Matt Ruen, Emily Stenberg, and Monica Westin, who proposed a task force to tackle the issues raised. This task force was charged with creating an Ethical Framework for Library Publishing . From July of 2017 to June of 2018, the task force members (listed on the title page as authors of this document) identified the topics to be covered in the framework, and then worked in subgroups to review the literature on those topics and identify existing resources of particular relevance to the community of library publishers. The subgroups then drafted the sections you see in this document. Throughout this process, they worked iteratively to devise a structure and format for the framework—a challenging task, and one for which there were many inspirations, but no clear models. In the end, they decided that the most effective structure for the document would break each section into an introduction , a scope statement , a review of existing resources , and a set of recommendations for library publishers. Some sections also include a note about new resources that are needed and/or further readings on the topic. Context: library publishing and ethics: Academic libraries have entered the publishing space due to changes in ways of disseminating information and in response to faculty members’ desire to control their own publishing destiny. This work has been enabled by the emergence of open source or low-cost technologies for publishing, but the motivations for it are broad and deep—for example, library publishers are also deeply engaged with emerging forms of scholarship (and emerging disciplines) that do not yet have a voice within the traditional publishing environment. These motivations often include a desire for increased openness and sustainability in the scholarly communication landscape. Unlike commercial publishers and traditional presses, the work of library publishers is largely funded through existing library budgets without a profit motive. The goal is instead to increase the impact of scholarship created by faculty and students affiliated with an institution and to disseminate that scholarship as broadly as possible, by emphasizing open access as a means of distribution. Because these publishing activities for academic libraries are a relatively recent endeavor, education and training for librarians as publishers is not fully established and thus one of the objectives for preparing this guide. Publishing as a role for librarians is increasing in importance for all academic libraries and is not limited to just research libraries, but also includes community colleges and four-year undergraduate institutions. Library publishers are also uniquely positioned to look beyond traditional prestige publishing priorities to partner with faculty, students, and organizations in order provide services such as data preservation and engage in publishing as pedagogy. As relative newcomers to the world of publishing, libraries are able to draw on a wealth of resources and expertise developed by more established players. To avoid reinventing the wheel, this document is structured primarily around existing resources. The framework pulls together existing publishing codes of ethics (many of which are included in the Publishing Practice section), along with resources from librarianship and other related fields, and contextualizes them for library publishers. The recommendations in each section attempt to distill a wealth of knowledge and guidance into a small set of actionable steps meant to answer the question, “But how do I get started?” They are by no means the only steps to be taken in these areas, but they may help library publishers begin to incorporate these important ethical considerations into their work. Future plans for the framework From the beginning of this project, the taskforce designed An Ethical Framework for Library Publishing to be an iterative document, more formal than a wiki but less so than a monograph or white paper. The founding group of authors worked on the framework with an understanding that every topic could not be covered, especially with a goal to create a document in less than a year. This framework was always envisioned as a starting place. In light of an iterative approach, we have decided to call this version 1 from the outset. The definitive version of An Ethical Framework for Library Publishing will always be the most current version. Versioning the document will also help make visible the historical transition. Version 2, the taskforce hopes, can be started by a new group of library publishing professionals with new views and ideas. In this way, we hope, An Ethical Framework for Library Publishing will never be a static, antiquated document created only from the viewpoint of a small group of people. It can, and should, be a community project