Determining how atmospheric carbon dioxide concentrations have changed during the history of the Earth

The reconstruction of ancient atmospheric carbon dioxide concentrations is essential to understanding the history of the Earth and life. It is also an important guide to identifying the sensitivity of the Earth system to this greenhouse gas and, therefore, constraining its future impact on climate. However, determining the concentration of CO2 in ancient atmospheres is a challenging endeavour requiring the application of state-of-the-art analytical chemistry to geological materials, underpinned by an understanding of photosynthesis and biochemistry. It is truly an interdisciplinary challenge

Expected and unexpected products of reactions of 2-hydrazinylbenzothiazole with 3-nitrobenzenesulfonyl chloride in different solvents

Acknowledgements We thank the EPSRC National Crystallography Service (University of Southampton) for the X-ray data collections. Funding information MVNdS and JLW thank CNPq (Brazil) for financial support.Peer reviewedPublisher PD

Following one's heart: cardiac rhythms gate central initiation of sympathetic reflexes

Central nervous processing of environmental stimuli requires integration of sensory information with ongoing autonomic control of cardiovascular function. Rhythmic feedback of cardiac and baroreceptor activity contributes dynamically to homeostatic autonomic control. We examined how the processing of brief somatosensory stimuli is altered across the cardiac cycle to evoke differential changes in bodily state. Using functional magnetic resonance imaging of brain and noninvasive beat-to-beat cardiovascular monitoring, we show that stimuli presented before and during early cardiac systole elicited differential changes in neural activity within amygdala, anterior insula and pons, and engendered different effects on blood pressure. Stimulation delivered during early systole inhibited blood pressure increases. Individual differences in heart rate variability predicted magnitude of differential cardiac timing responses within periaqueductal gray, amygdala and insula. Our findings highlight integration of somatosensory and phasic baroreceptor information at cortical, limbic and brainstem levels, with relevance to mechanisms underlying pain control, hypertension and anxiety

A Complete Theory of Everything (will be subjective)

Increasingly encompassing models have been suggested for our world. Theories range from generally accepted to increasingly speculative to apparently bogus. The progression of theories from ego- to geo- to helio-centric models to universe and multiverse theories and beyond was accompanied by a dramatic increase in the sizes of the postulated worlds, with humans being expelled from their center to ever more remote and random locations. Rather than leading to a true theory of everything, this trend faces a turning point after which the predictive power of such theories decreases (actually to zero). Incorporating the location and other capacities of the observer into such theories avoids this problem and allows to distinguish meaningful from predictively meaningless theories. This also leads to a truly complete theory of everything consisting of a (conventional objective) theory of everything plus a (novel subjective) observer process. The observer localization is neither based on the controversial anthropic principle, nor has it anything to do with the quantum-mechanical observation process. The suggested principle is extended to more practical (partial, approximate, probabilistic, parametric) world models (rather than theories of everything). Finally, I provide a justification of Ockham's razor, and criticize the anthropic principle, the doomsday argument, the no free lunch theorem, and the falsifiability dogma.Comment: 26 LaTeX page

Acute tryptophan depletion attenuates conscious appraisal of social emotional signals in healthy female volunteers

Rationale: Acute tryptophan depletion (ATD) decreases levels of central serotonin. ATD thus enables the cognitive effects of serotonin to be studied, with implications for the understanding of psychiatric conditions, including depression. Objective: To determine the role of serotonin in conscious (explicit) and unconscious/incidental processing of emotional information. Materials and methods: A randomized, double-blind, cross-over design was used with 15 healthy female participants. Subjective mood was recorded at baseline and after 4 h, when participants performed an explicit emotional face processing task, and a task eliciting unconscious processing of emotionally aversive and neutral images presented subliminally using backward masking. Results: ATD was associated with a robust reduction in plasma tryptophan at 4 h but had no effect on mood or autonomic physiology. ATD was associated with significantly lower attractiveness ratings for happy faces and attenuation of intensity/arousal ratings of angry faces. ATD also reduced overall reaction times on the unconscious perception task, but there was no interaction with emotional content of masked stimuli. ATD did not affect breakthrough perception (accuracy in identification) of masked images. Conclusions: ATD attenuates the attractiveness of positive faces and the negative intensity of threatening faces, suggesting that serotonin contributes specifically to the appraisal of the social salience of both positive and negative salient social emotional cues. We found no evidence that serotonin affects unconscious processing of negative emotional stimuli. These novel findings implicate serotonin in conscious aspects of active social and behavioural engagement and extend knowledge regarding the effects of ATD on emotional perception

Density functional theory calculations of adsorption-induced surface stress changes

Density functional theory calculations of adsorbate-induced surface stress changes have been performed for a number of adsorbate and overlayer systems for which experimental data exists, namely: oxygen and sulphur adsorption on Ni(1 0 0); oxygen adsorption on W(1 1 0); pseudomorphic growth of Ni on Cu(1 0 0) and of Fe on W(1 1 0); oxygen adsorption on a 5 ML pseudomorphic film of Ni(1 0 0) grown on Cu(1 0 0). The theoretical calculations reproduce all the qualitative features of the experimental data, but there are some significant quantitative differences, most notably for the two atomic adsorbates on the bulk Ni(1 0 0) surface, for which the theoretical stress changes are substantially smaller than the experimental ones, a situation not obviously attributable to experimental error. For the W(1 1 0)/Fe system there is also a marked difference between experiment and theory in the coverage at which key surface stress changes occur

Control of oscillatory convolution operators via maximal functions in weighted L² inequalities

This thesis is concerned with the weighted L² boundedness of a family of convolution operators on the line with oscillating kernels. It is proved that these convolution operators are bounded from L²(w) to L²(W) where the Borel measures w and W are in a correspondence given by a maximal function and there is a sense in which this maximal function is the best possible. It is also shown that a one-weighted L² estimate holds for a family of convolution operators with radial oscillating kernels on n-dimensional space.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

War Crimes and Complementarity at the ICC: How the United States of America and the United Kingdom Have Responded to War Crimes Allegations

This thesis will discuss the responses of the United States of America and the United Kingdom to allegations that their personnel have committed war crimes in the context of the armed conflicts in Afghanistan, and Iraq, respectively. This will be done in order to assess the extent to which these responses have complied with the principle of complementarity as found at the International Criminal Court (ICC). This is a topic of importance since such allegations have been subject to ICC scrutiny in recent years, and compliance with the principle of complementarity is a way in which both States can avoid further scrutiny. The discussion in relation to the United States centres around an analysis of criminal law applicable to allegations under scrutiny by the ICC Office of the Prosecutor (OTP); an examination of the Report of the Senate Armed Services Committee on the treatment of detainees in US armed forces custody, as well as the Senate Intelligence Committee’s Report on the CIA’s detention and interrogation program; before discussing the criminal investigation process in the United States. The discussion of the United Kingdom will also analyse the framework of law applicable to the crimes under OTP scrutiny, before discussing the extent to which the Baha Mousa Report demonstrates that the UK has complied with the principle of complementarity. The analysis of the UK also includes chapters discussing the impact of the Iraq Historic Allegations Team, and the potential impact of legislation aimed at preventing vexatious prosecutions. The thesis concludes by arguing whether the analysis of the situation in these two States is reflective of how the principle of complementarity was envisaged to apply at the time the Rome Statute was created