1,149 research outputs found
STAT1 activation in association with JAK2 exon 12 mutations
La inclusión de la perspectiva de género en la actividad jurisdiccional es una demanda sostenida de los colectivos feministas y de mujeres, dado que las sentencias tienen un poder performativo y envían un mensaje a la sociedad: “[…] tienen un poder individual y colectivo que impactan en la vida de las personas y conforman la identidad del poder judicial como un actor imprescindible en la construcción de un Estado democrático de derecho” (Suprema Corte de Justicia de la Nación, 2013:7). La incorporación de la perspectiva de género viene a garantizar la igualdad de posiciones (Kessler, 2014) entre mujeres y varones como una meta, trascendiendo la mera igualdad de oportunidades que hasta el presente se ha demostrado insuficiente para que las mujeres consigamos una ciudadanía plena. Al momento de incorporar la perspectiva de género en las sentencias, quienes juzgan deben tener presente en primer lugar, el impacto diferenciado de las normas en base al sexo de las personas. En segundo lugar, la interpretación y aplicación de las leyes en relación con (y en base a) estereotipos de género. Si, por ejemplo, quienes imparten justicia no tienen presentes los estereotipos de género vigentes detrás de las violaciones a los derechos humanos de las mujeres, si no los detectan ni cuestionan, entonces los reproducen. Tal como sostiene Scott (1996) el género es una categoría imprescindible para el análisis social. En tercer lugar, al momento del juzgamiento, se deben tener en cuenta las exclusiones legitimadas por la ley por pensar el mundo en términos binarios y androcéntricos; en cuarto lugar, la distribución no equitativa de recursos y poder que opera entre varones y mujeres en el marco de una organización social patriarcal, y, por último, el trato diferenciado por género legitimado por las propias leyes.Eje 3: Tramas violentas y espacios de exclusión.Instituto de Cultura Jurídic
A quantum mechanical relation connecting time, temperature, and cosmological constant of the universe: Gamow's relation revisited as a special case
Considering our expanding universe as made up of gravitationally interacting
particles which describe particles of luminous matter and dark matter and dark
energy which is described by a repulsive harmonic potential among the points in
the flat 3-space, we derive a quantum mechanical relation connecting,
temperature of the cosmic microwave background radiation, age, and cosmological
constant of the universe. When the cosmological constant is zero, we get back
the Gamow's relation with a much better coefficient. Otherwise, our theory
predicts a value of the cosmological constant
when the present values of cosmic microwave background temperature of 2.728 K
and age of the universe 14 billion years are taken as input.Comment: 4 pages, 1 figure, Study of the Universe from a condensed matter
point of view, section III corrected with a single body potentia
Late Holocene glaciers in western Scotland?
In this paper we use a numerical glacier-climate model, a detailed photogrammetric survey and lichenometry to reconstruct small palaeoglaciers on Ben Nevis and surrounding mountains in western Scotland. These glaciers would have been sustained under a climate where the mean annual air temperature was –1.0°C to –2.0°C compared to present-day values either with or without a decrease in precipitation amount of 10–30%. Historical meteorological data show that these air temperatures were reached on Ben Nevis in the latter part of the 19th century. Although we have no data on the age of these small glaciers, palaeoclimate reconstructions suggest that such conditions almost certainly existed several times during the Holocene in Scotland; the last time being the Little Ice Age of the 16th to 19th Centuries. We argue from this that small Scottish glaciers may have been able to develop in high sheltered cirques at many times during the Holocene and that the glacial history of Scotland therefore requires revision
Superconducting p-branes and Extremal Black Holes
In Einstein-Maxwell theory, magnetic flux lines are `expelled' from a black
hole as extremality is approached, in the sense that the component of the field
strength normal to the horizon goes to zero. Thus, extremal black holes are
found to exhibit the sort of `Meissner effect' which is characteristic of
superconducting media. We review some of the evidence for this effect, and do
present new evidence for it using recently found black hole solutions in string
theory and Kaluza-Klein theory. We also present some new solutions, which arise
naturally in string theory, which are non-superconducting extremal black holes.
We present a nice geometrical interpretation of these effects derived by
looking carefully at the higher dimensional configurations from which the lower
dimensional black hole solutions are obtained. We show that other extremal
solitonic objects in string theory (such as p-branes) can also display
superconducting properties. In particular, we argue that the relativistic
London equation will hold on the worldvolume of `light' superconducting
p-branes (which are embedded in flat space), and that minimally coupled zero
modes will propagate in the adS factor of the near-horizon geometries of
`heavy', or gravitating, superconducting p-branes.Comment: 22 pages, 2 figure
Particle physics models of inflation
Inflation models are compared with observation on the assumption that the
curvature perturbation is generated from the vacuum fluctuation of the inflaton
field. The focus is on single-field models with canonical kinetic terms,
classified as small- medium- and large-field according to the variation of the
inflaton field while cosmological scales leave the horizon. Small-field models
are constructed according to the usual paradigm for beyond Standard Model
physicsComment: Based on a talk given at the 22nd IAP Colloquium, ``Inflation +25'',
Paris, June 2006 Curve omitted from final Figur
Cosmological Implications of Neutrinos
The lectures describe several cosmological effects produced by neutrinos.
Upper and lower cosmological limits on neutrino mass are derived. The role that
neutrinos may play in formation of large scale structure of the universe is
described and neutrino mass limits are presented. Effects of neutrinos on
cosmological background radiation and on big bang nucleosynthesis are
discussed. Limits on the number of neutrino flavors and mass/mixing are given.Comment: 41 page, 7 figures; lectures presented at ITEP Winter School,
February, 2002; to be published in the Proceeding
Virus shapes and buckling transitions in spherical shells
We show that the icosahedral packings of protein capsomeres proposed by
Caspar and Klug for spherical viruses become unstable to faceting for
sufficiently large virus size, in analogy with the buckling instability of
disclinations in two-dimensional crystals. Our model, based on the nonlinear
physics of thin elastic shells, produces excellent one parameter fits in real
space to the full three-dimensional shape of large spherical viruses. The
faceted shape depends only on the dimensionless Foppl-von Karman number
\gamma=YR^2/\kappa, where Y is the two-dimensional Young's modulus of the
protein shell, \kappa is its bending rigidity and R is the mean virus radius.
The shape can be parameterized more quantitatively in terms of a spherical
harmonic expansion. We also investigate elastic shell theory for extremely
large \gamma, 10^3 < \gamma < 10^8, and find results applicable to icosahedral
shapes of large vesicles studied with freeze fracture and electron microscopy.Comment: 11 pages, 12 figure
On the degree of scale invariance of inflationary perturbations
Many, if not most, inflationary models predict the power-law index of the
spectrum of density perturbations is close to one, though not precisely equal
to one, |n-1| \sim O(0.1), implying that the spectrum of density perturbations
is nearly, but not exactly, scale invariant. Some models allow n to be
significantly less than one (n \sim 0.7); a spectral index significantly
greater than one is more difficult to achieve. We show that n \approx 1 is a
consequence of the slow-roll conditions for inflation and ``naturalness,'' and
thus is a generic prediction of inflation. We discuss what is required to
deviate significantly from scale invariance, and then show, by explicit
construction, the existence of smooth potentials that satisfy all the
conditions for successful inflation and give as large as 2.Comment: 7 pages, 2 figures, submitted to Phys. Rev.
Interplanetary Scintillation Observations of Stream Interaction Regions in the Solar Wind
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms
Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance in JAK2V617F-negative MPN: rs12339666 (JAK2; meta-analysis P=1.27 × 10−10) and rs2201862 (MECOM; meta-analysis P=1.96 × 10−9). Two additional SNPs, rs2736100 (TERT) and rs9376092 (HBS1L/MYB), achieve genome-wide significance when including JAK2V617F-positive cases. rs9376092 has a stronger effect in JAK2V617F-negative cases with CALR and/or MPL mutations (Breslow–Day P=4.5 × 10−7), whereas in JAK2V617F-positive cases rs9376092 associates with essential thrombocythemia (ET) rather than polycythemia vera (allelic χ2 P=7.3 × 10−7). Reduced MYB expression, previously linked to development of an ET-like disease in model systems, associates with rs9376092 in normal myeloid cells. These findings demonstrate that multiple germline variants predispose to MPN and link constitutional differences in MYB expression to disease phenotype
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