Systematic review of the effects of bisphosphonates on bone density and fracture incidence in childhood acute lymphoblastic leukaemia

Skeletal fragility is a common complication of childhood acute lymphoblastic leukaemia (ALL) but the impact of bisphosphonate therapy on bone mass and fracture is unclear. We aim to conduct a systematic review to evaluate the effects of bisphosphonates on bone mineral density (BMD) and fracture incidence in children with ALL. EMBASE, Medline and the Cochrane Library were thoroughly searched by two researchers. Inclusion criteria was any child under the age of 18 years with a diagnosis of ALL, who had received any bisphosphonate treatment and had serial measurements of bone density performed thereafter. All primary research studies of any study design, excluding case reports, were included. Ten full text papers were identified with two exclusively meeting the inclusion criteria. Both studies administered bisphosphonates to children receiving maintenance chemotherapy for varying durations. Bone density was assessed at regular intervals by dual x-ray absorptiometry (DXA). The majority of participants had an improvement in bone density at the end of each study. However, no size adjustment of DXA data was performed. Limited information on fracture occurrence was provided by one study but did not include routine screening for vertebral fractures. This systematic review identified that there is insufficient evidence to support routine use of prophylactic bisphosphonate therapy in childhood ALL for prevention of fracture and improvement of bone mass. Future well-designed clinical trials in those at highest risk of fractures in ALL are now needed

Fictitious fluxes in doped antiferromagnets

In a tight binding model of charged spin-1/2 electrons on a square lattice, a fully polarized ferromagnetic spin configuration generates an apparent U(1) flux given by $2\pi$ times the skyrmion charge density of the ferromagnetic order parameter. We show here that for an antiferromagnet, there are two ``fictitious'' magnetic fields, one staggered and one unstaggered. The staggered topological flux per unit cell can be varied between $-\pi\le\Phi\le\pi$ with a negligible change in the value of the effective nearest neighbor coupling constant whereas the magnitude of the unstaggered flux is strongly coupled to the magnitude of the second neighbor effective coupling.Comment: RevTeX, 5 pages including 4 figure

Brane decay of a (4+n)-dimensional rotating black hole: spin-0 particles

In this work, we study the `scalar channel' of the emission of Hawking radiation from a (4+n)-dimensional, rotating black hole on the brane. We numerically solve both the radial and angular part of the equation of motion for the scalar field, and determine the exact values of the absorption probability and of the spheroidal harmonics, respectively. With these, we calculate the particle, energy and angular momentum emission rates, as well as the angular variation in the flux and power spectra -- a distinctive feature of emission during the spin-down phase of the life of the produced black hole. Our analysis is free from any approximations, with our results being valid for arbitrarily large values of the energy of the emitted particle, angular momentum of the black hole and dimensionality of spacetime. We finally compute the total emissivities for the number of particles, energy and angular momentum and compare their relative behaviour for different values of the parameters of the theory.Comment: 24 pages, 13 figure

Semiclassical Trace Formulas for Noninteracting Identical Particles

We extend the Gutzwiller trace formula to systems of noninteracting identical particles. The standard relation for isolated orbits does not apply since the energy of each particle is separately conserved causing the periodic orbits to occur in continuous families. The identical nature of the particles also introduces discrete permutational symmetries. We exploit the formalism of Creagh and Littlejohn [Phys. Rev. A 44, 836 (1991)], who have studied semiclassical dynamics in the presence of continuous symmetries, to derive many-body trace formulas for the full and symmetry-reduced densities of states. Numerical studies of the three-particle cardioid billiard are used to explicitly illustrate and test the results of the theory.Comment: 29 pages, 11 figures, submitted to PR

Exact asymptotics of the freezing transition of a logarithmically correlated random energy model

We consider a logarithmically correlated random energy model, namely a model for directed polymers on a Cayley tree, which was introduced by Derrida and Spohn. We prove asymptotic properties of a generating function of the partition function of the model by studying a discrete time analogy of the KPP-equation - thus translating Bramson's work on the KPP-equation into a discrete time case. We also discuss connections to extreme value statistics of a branching random walk and a rescaled multiplicative cascade measure beyond the critical point

Brane Decay of a (4+n)-Dimensional Rotating Black Hole. II: spin-1 particles

The present works complements and expands a previous one, focused on the emission of scalar fields by a (4+n)-dimensional rotating black hole on the brane, by studying the emission of gauge fields on the brane from a similar black hole. A comprehensive analysis of the particle, energy and angular momentum emission rates is undertaken, for arbitrary angular momentum of the black hole and dimensionality of spacetime. Our analysis reveals the existence of a number of distinct features associated with the emission of spin-1 fields from a rotating black hole on the brane, such as the behaviour and magnitude of the different emission rates, the angular distribution of particles and energy, the relative enhancement compared to the scalar fields, and the magnitude of the superradiance effect. Apart from their theoretical interest, these features can comprise clear signatures of the emission of Hawking radiation from a brane-world black hole during its spin-down phase upon successful detection of this effect during an experiment.Comment: 35 pages, 19 figures, Latex fil

Brane Decay of a (4+n)-Dimensional Rotating Black Hole. III: spin-1/2 particles

In this work, we have continued the study of the Hawking radiation on the brane from a higher-dimensional rotating black hole by investigating the emission of fermionic modes. A comprehensive analysis is performed that leads to the particle, power and angular momentum emission rates, and sheds light on their dependence on fundamental parameters of the theory, such as the spacetime dimension and angular momentum of the black hole. In addition, the angular distribution of the emitted modes, in terms of the number of particles and energy, is thoroughly studied. Our results are valid for arbitrary values of the energy of the emitted particles, dimension of spacetime and angular momentum of the black hole, and complement previous results on the emission of brane-localised scalars and gauge bosons.Comment: Latex file, JHEP style, 34 pages, 16 figures Energy range in plots increased, minor changes, version published in JHE

A reanalysis of the luminosities of clusters of galaxies in the EMSS sample with 0.3 < z < 0.6

The X-ray luminosities of the Einstein Extended Medium Sensitivity Survey (EMSS) clusters of galaxies with redshifts 0.3<z<0.6 are remeasured using ROSAT PSPC data. It is found that the new luminosities are on average 1.18 +/- 0.08 times higher than previously measured but that this ratio depends strongly on the X-ray core radii we measure. For the clusters with small core radii, in general we confirm the EMSS luminosities, but for clusters with core radii >250 kpc (the constant value assumed in the EMSS), the new luminosities are 2.2 +/- 0.15 times the previous measurements. The X-ray luminosity function (XLF) at 0.3<z<0.6 is recalculated and is found to be consistent with the local XLF. The constraints on the updated properties of the 0.3<z<0.6 EMSS sample, including a comparison with the number of clusters predicted from local XLFs, indicate that the space density of luminous, massive clusters has either not evolved or has increased by a small factor ~2 since z=0.4. The implications of this result are discussed in terms of constraints on the cosmological parameter Omega_0.Comment: 12 pages, 7 figures. Accepted for publication in MNRA

Radiative Corrections to One-Photon Decays of Hydrogenic Ions

Radiative corrections to the decay rate of n=2 states of hydrogenic ions are calculated. The transitions considered are the M1 decay of the 2s state to the ground state and the E1(M2) decays of the $2p_{1/2}$ and $2p_{3/2}$ states to the ground state. The radiative corrections start in order $\alpha (Z \alpha)^2$, but the method used sums all orders of $Z\alpha$. The leading $\alpha (Z\alpha)^2$ correction for the E1 decays is calculated and compared with the exact result. The extension of the calculational method to parity nonconserving transitions in neutral atoms is discussed.Comment: 22 pages, 2 figure