Doublet-triplet splitting in fertile left-right symmetric heterotic string vacua

Classification of Left-Right Symmetric (LRS) heterotic-string vacua in the free fermionic formulation, using random generation of generalised GSO (GGSO) projection coefficients, produced phenomenologically viable models with probability $4\times 10^{-11}$. Extracting substantial number of phenomenologically viable models requires modification of the classification method. This is achieved by identifying phenomenologically amenable conditions on the Generalised GSO projection coefficients that are randomly generated at the $SO(10)$ level. Around each of these fertile cores we perform a complete LRS classification, generating viable models with probabilility $1.4\times 10^{-2}$, hence increasing the probability of generating phenomenologically viable models by nine orders of magnitude, and producing some $1.4\times 10^5$ such models. In the process we identify a doublet-triplet selection mechanism that operates in twisted sectors of the string models that break the $SO(10)$ symmetry to the Pati-Salam subgroup. This mechanism therefore operates as well in free fermionic models with Pati-Salam and Standard-like Model $SO(10)$ subgroups.Comment: 30 pages. 1 figure. Published versio

Molecular quadratic nonlinear optical properties of dipolar ruthenium(II) arsine complexes

A series of complex salts in which trans-bis[1,2-phenylenebis(dimethylarsine)]chlororuthenium(II) electron donor groups are connected to pyridyl or pyridinium electron acceptors has been prepared. These chromophores exhibit intense, visible metal-to-ligand charge-transfer (MLCT) absorptions and reversible Ru(III/II) (and also in some cases ligand-based) redox processes. Stark (electroabsorption) spectroscopic studies have been used to determine dipole moment changes for the MLCT excitations. Static first hyperpolarizabilities have been calculated according to the two-state model, allowing the derivation of structure-activity correlations for the molecular quadratic nonlinear optical responses

The DDX6-4E-T interaction mediates translational repression and P-body assembly.

4E-Transporter binds eIF4E via its consensus sequence YXXXXLΦ, shared with eIF4G, and is a nucleocytoplasmic shuttling protein found enriched in P-(rocessing) bodies. 4E-T inhibits general protein synthesis by reducing available eIF4E levels. Recently, we showed that 4E-T bound to mRNA however represses its translation in an eIF4E-independent manner, and contributes to silencing of mRNAs targeted by miRNAs. Here, we address further the mechanism of translational repression by 4E-T by first identifying and delineating the interacting sites of its major partners by mass spectrometry and western blotting, including DDX6, UNR, unrip, PAT1B, LSM14A and CNOT4. Furthermore, we document novel binding between 4E-T partners including UNR-CNOT4 and unrip-LSM14A, altogether suggesting 4E-T nucleates a complex network of RNA-binding protein interactions. In functional assays, we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis. We also show that the DDX6-4E-T interaction mediates miRNA-dependent translational repression and de novo P-body assembly, implying that translational repression and formation of new P-bodies are coupled processes. Altogether these findings considerably extend our understanding of the role of 4E-T in gene regulation, important in development and neurogenesis.BBSRC [BB/J00779X/1 to N.S.]; CNRS PICS (to D.W.); Agence Nationale pour la Recherche [ANR-14-CE09-0013-01ANR to D.W.]; Gates Cambridge Foundation (to A.K.); Fondation Wiener – Anspach of the Université Libre de Bruxelles and the Cambridge Newton Trust (C.V.). Funding for open access charge: BBSRC

Imaging the warped dusty disk wind environment of SU Aurigae with MIRC-X

SU Aurigae is a widely studied T Tauri star and here we present original state-of-the-art interferometric observations with better uv and baseline coverage than previous studies. We aim to investigate the characteristics of the circumstellar material around SU Aur, constrain the disk geometry, composition and inner dust rim structure. The MIRC-X instrument at CHARA is a 6 telescope optical beam combiner offering baselines up to 331 m. We undertook image reconstruction for model-independent analysis, and fitted geometric models such as Gaussian and ring distributions. Additionally, the fitting of radiative transfer models constrains the physical parameters of the disk. Image reconstruction reveals a highly inclined disk with a slight asymmetry consistent with inclination effects obscuring the inner disk rim through absorption of incident star light on the near-side and thermal re-emission/scattering of the far-side. Geometric models find that the underlying brightness distribution is best modelled as a Gaussian with a FWHM of $1.53\pm0.01 \mathrm{mas}$ at an inclination of $56.9\pm0.4^\circ$ and minor axis position angle of $55.9\pm0.5^\circ$. Radiative transfer modelling shows a flared disk with an inner radius at 0.16 au which implies a grain size of $0.14 \mathrm{\mu m}$ assuming astronomical silicates and a scale height of 9.0 au at 100 au. In agreement with literature, only the dusty disk wind successfully accounts for the NIR excess by introducing dust above the mid-plane. Our results confirm and provide better constraints than previous inner disk studies of SU Aurigae. We confirm the presence of a dusty disk wind in the cicumstellar environment, the strength of which is enhanced by a late infall event which also causes very strong misalignments between the inner and outer disks.Comment: arXiv admin note: substantial text overlap with arXiv:2111.06205, arXiv:1905.1190

The Utility of Video Diaries for Organizational Research

This article assesses the utility of video diaries as a method for organization studies. While it is frequently suggested that video-based research methodologies have the capacity to capture new data about the minutiae of complex organizational affairs, as well as offering new forms of dissemination to both academic and professional audiences, little is known about the specific benefits and drawbacks of video diaries. We compare video diaries with two established and “adjacent” methods: traditional diary studies (written or audio) and other video methods. We evaluate each in relation to three key research areas: bodily expressions, identity, and practice studies. Our assessment of video diaries suggests that the approach is best used as a complement to other forms of research and is particularly suited to capturing plurivocal, asynchronous accounts of organizational phenomena. We use illustrations from an empirical research project to exemplify our claims before concluding with five points of advice for researchers wishing to employ this method

Pentacyanoiron(II) as an Electron Donor Group for Nonlinear Optics: Medium-Responsive Properties and Comparisons with Related Pentaammineruthenium(II) Complexes

In this article, we describe a series of complex salts in which electron-rich {Fe^(II)(CN)_5}^(3-) centers are coordinated to pyridyl ligands with electron-accepting N-methyl/aryl-pyridinium substituents. These compounds have been characterized by using various techniques including electronic absorption spectroscopy and cyclic voltammetry. Molecular quadratic nonlinear optical (NLO) responses have been determined by using hyper-Rayleigh scattering (HRS) at 1064 nm, and also via Stark (electroabsorption) spectroscopic studies on the intense, visible d → π* metal-to-ligand charge-transfer (MLCT) bands. The relatively large static first hyperpolarizabilities, β_0, increase markedly on moving from aqueous to methanol solutions, accompanied by large red-shifts in the MLCT transitions. Acidification of aqueous solutions allows reversible switching of the linear and NLO properties, as shown via both HRS and Stark experiments. Time-dependent density functional theory and finite field calculations using a polarizable continuum model yield relatively good agreement with the experimental results and confirm the large decrease in β0 on protonation. The Stark-derived β0 values are generally larger for related {Ru^(II)(NH_3)_5}^(2+) complexes than for their {Fe^(II)(CN)_5}^(3-) analogues, consistent with the HRS data in water. However, the HRS data in methanol show that the stronger solvatochromism of the Fe^(II) complexes causes their NLO responses to surpass those of their Ru^(II) counterparts upon changing the solvent medium

Who's been framed? Framing effects are reduced in financial gambles made for others

Background: Decisions made on behalf of other people are sometimes more rational than those made for oneself. In this study we used a monetary gambling task to ask if the framing effect in decision-making is reduced in surrogate decision-making. Methods: Participants made a series of choices between a predetermined sure option and a risky gambling option of winning a proportion of an initial stake. Trials were presented as either a gain or a loss relative to that initial stake. In half of the trials participants made choices to earn money for themselves and in the other half they earned money for another participant. Framing effects were measured as risk seeking in loss frames and risk aversion in gain frames. Results: Significant framing effects were observed both in trials in which participants earned money for themselves and those in which they earned money for another person; however, these framing effects were significantly reduced when making decisions for another person. It appears that the reduced emotional involvement when the decision-maker is not affected by the outcome of the decision thus lessens the framing effect without eradicating it altogether. Conclusions: This suggests that the deviation from rational choices in decision-making can be significantly reduced when the emotional impact on the decision maker is lessened. These results are discussed in relation to Somatic Distortion Theory