197 research outputs found
ํ๊ทผ๋ ์๋์ ์ ํ ๊ธฐ๋ฅ์ฃผ์ ๋ฏผ์กฑ์ง์ ์์ : ์ค๊ตญ ๋ฏผ์กฑ์ง์ ํฉ๊ธ๊ธฐ๋ก๋ถํฐ์ ๊ตํ
์ด ๊ธ์ ํ์๊ฐ ๋น๊ต๋ฌธํ์ฐ๊ตฌ์ ์ฝ๋กํค์์์ ๋ฐํํ The Worth of Postwar Functionalist Ethnography in the Postmodern Age: Lessons from the Golden Age of China Ethnography๋ฅผ ๋ฒ์ญํ ๊ฒ์ด๋ค.1957๋
๋ฒ ๋ฅด๋๋ฅด ๊ฐ๋ฆฐ(Bemard Gallin)๊ณผ ๋ฆฌํ ๊ฐ๋ฆฐ(Rita Gallin)์ ์ ์ฑ(ๆฐ่) ๋ง์์์ ํ์ง์กฐ์ฌ๋ฅผ ์ํํ๊ธฐ ์ํด ์ฐฝํ(ๅฝฐๅ)ํ์ ๋์ฐฉํ๊ณ (Gallin 1966: 4-5), ์๋ ์ธํ(Arthur Wolf)์ ๋ง์ ๋ฆฌ ์ธํ(Margery Wolf)๋ ์์์์กฐ์ฐ(ไธ่ฅฟๅจ) ๋ง์์ ์ฐ๊ตฌํ๊ธฐ ์ํด ํ์ดํ์ด(ๅฐๅ)ํ์ ๋์ฐฉํ๋ค(Wolf 1968: vii). ์ค๊ตญ ๋ฏผ์กฑ์ง์ ํฉ๊ธ๊ธฐ๊ฐ ์์๋ ์์ ์ ์ด์ ๊ฐ์ด ๊ธฐ๋ก์ ๋ช
์๋์ด ์๋ ๋ฐ๋ฉด, ๊ทธ๊ฒ์ด ๋๋ ์์ ์ ๋ถ๋ช
์น๊ฐ ์๋ค. ์ค๊ตญ ๊ณผํ์(์์ง ์ค๊ตญ ์ฌํ๊ณผํ์์ผ๋ก ๋๋์ง ์์๋)์ด ์ผ๋จ์ ์๊ตฌ ์ฌํ๊ณผํ์๋ค์๊ฒ ์ค๊ตญ ๋์ด์ ๋ํ ์คํ์ ์ธ ํ์ง ์กฐ์ฌ๋ฅผ ํ๊ฐํด ์ฃผ์๋ค๋ ๊ณต์ ๋ฐํ๋ฅผ ํ ๋๋ก ๊ทธ ์๊ธฐ ๋ฅผ ๋๋ต 1978๋
๋ง ๊ฒฝ์ผ๋ก ์ถ์ ํ ์ ์๋ค.
๊ทธ ๋น์๋ ๋๋ง์ด ์ ์น์ ์ผ๋ก๋ฟ๋ง ์๋๋ผ ์ธ๋ฅํ์ ์ผ๋ก๋ ์ค๊ตญ์ ๋์ ํ๋ ์๊ธฐ์๋ค. ์ค๊ตญ ๋ณธํ ๋ก๋ถํฐ ์ถ์ถ๋นํ ์ธ๊ตญ ์ธ๋ฅํ๊ณผ๋ค(๋๋ค์๊ฐ ๋ฏธ๊ตญ์ธ์ด์๋)์ ์ฐจ์ ์ฑ
์ผ๋ก ๋๋ง์ผ๋ก ์ฎ๊ฒจ๊ฐ๋ค. ๋น์ ๋๋ง์๋ ์ค๊ตญ ๋ฌธํ๊ฐ ๊ณ์ํด์ ๋ฒ์ฐฝํ๊ณ ์์์ ๋ฟ ์๋๋ผ ๊ณต์ฐ์ฃผ์์๋ค์ ์นจํ๋ ์กด์ฌํ์ง ์์๊ธฐ ๋๋ฌธ์ด๋ค.
ํฉ๊ธ๊ธฐ์ ๋๋ง์ ๋ฏผ์กฑ์ง๋ค์ ๋๋ง์ด ์ค๊ตญ์ผ๋ก ๊ฐ์ฃผ๋์๋ ๋น์์ ์ ์น์ ์ํฉ๊ณผ ์ง์ ์ ์ธ ๊ด๋ จ์ด ์๋ ์ผ๋ จ์ ํธ๊ฒฌ์ ๋ด๊ณ ์๋๋ฐ, ์ด๋ฌํ ํธ๊ฒฌ์ 80๋
๋์ 90๋
๋์ ๋ถ์์ ํ ํ๋ช
์ ๊ฑฐ์น๊ธฐ ์ด์ ์ ์ธ๋ฅํ์ ์ด๋ก ์ ๋ถ์๊ธฐ์ ๋ฐ์ ํ๊ฒ ๊ด๋ จ๋์ด ์๋ ๊ฒ์ด ๋ถ๋ช
ํ๋ค. ์ด๋ฌํ ํธ๊ฒฌ์๋ ๋ฌธํ์ ์ด์ฒด์ฑ์ด๋ผ๋ ์ด๋
๊ณผ ์ ์์ฃผ์(adaptationism), ๊ณต์์ฃผ์(synchronicism) ๋ฑ์ด ํฌํจ๋๋ค. ๋๋ ์ด๋ค ํธ๊ฒฌ๋ค๊ณผ ์ด๋ฌํ ํธ๊ฒฌ๋ค์ ๋นํ์ ๊ด์ ์ผ๋ก ๋ฐ์ ์ํจ ๋ฏผ์กฑ์ง๋ค์ ์ฃผ์ ๋ก ๋ค๋ฃจ์ด ๋ณด๋ ค
๊ณ ํ๋ค. ํฉ๊ธ๊ธฐ์ ๋ฏผ์กฑ์ง๋ค์ ๋น๋ํ๊ธฐ ์ํด์ ์ด ๊ธ์ ์ฐ๋ ๊ฒ์ ์๋๋ค. ํ๋ฌผ๋ฉฐ ์ด๋ค ๋ฏผ์กฑ์ง๋ฅผ ์ค๊ตญ ๊ณต์ฐ๋น์ด ์์ ์ญ์ฌ์ ๊ณผ์ค์ด๋ผ๊ณ ๋ถ๋ ๋ ๊ฒ์ผ๋ก ์น๋ถํ๊ธฐ ์ํด์๋ ๋๋์ฑ ์๋๋ค. ๋๋ ์คํ๋ ค ๊ฑด์ค์ ์ธ ์ธ ๊ฐ์ง ์ง๋ฌธ์ ๋์ง๊ณ ์ ํ๋ค. ์ฒซ์งธ, ํฉ๊ธ๊ธฐ์ ์ธ๋ฅํ์๋ค์ด ๋๋ง์ ๊ดํ ๊ธ์ ์ฐ๋ ๊ณผ์ ์์ ๋ฌด์์ด ํฌํจ๋๊ณ ๋ฌด์์ด ๋ฐฐ์ ๋์๋๊ฐ? ์ด๋ฌํ ๋ฐฐ์ ์ ํฌํจ์ ์ ํ์ด ์ญ์ฌ์ ๋ณํ์ ์ฐ์์ ๊ดํ ๊ธฐ์ ๊ณผ ํด์์ ๊ฐ๋ฅ์ฑ์ ์ด๋ค ์ํฅ์ ๋ฏธ์น๋๊ฐ? ๋์งธ, ํน์ ํ ์ ํ์ ๊ฐ์ ์ด
๋ ํธ๊ฒฌ๊ณผ ๊ด๋ จ์์ผ ๋ณผ ๋ ํฉ๊ธ๊ธฐ ๋ฏผ์กฑ์ง๋ค์ ์ด๋ก ์ ๋ฌธ์ ๋ค์ ๊ทธ๊ฒ๋ค์ ์ดํดํ๊ณ ๋ค๋ฃจ๋ ์ฐ๋ฆฌ๋ค ์์ ์ ๊ฐ๋ฅ์ฑ์ ์ด๋ค ์์ผ๋ก ์ ์ฝํ๋๊ฐ? ๋ง์ง๋ง์ผ๋ก, ์ด๋ฌํ ๋ฏผ์กฑ์ง๋ค์ ํํ ์ค๊ตญ์ ์ธ ๊ฒ์ผ๋ก ์ธ๊ธ๋๋ ์ํธ ์ฐ๊ด๋ ๋ฌธํ์ ๋ณ์ดํ๋ค์ ๋งฅ๋ฝ ์์์ ๋๋ง ๋ฌธํ์ ๋ํด ์ด๋ค ์์ฌ์ ์ ์ ๊ณตํ๋๊ฐ
Design and development of the second generation Mars Habitat
The second generation of Mars Habitat is to be utilized as an advanced permanent base for 20 crew members to live on Mars for a period of 6-12 months. It is designed to be a self-contained environment accommodating five main facilities: living, working, service, medical, and a greenhouse. The objective of the design is to create a comfortable, safe, living environment. Hexamars-2 and Lavapolis-2 are two different concepts for the advanced Mars Habitat. The design team assumes there will be an initial habitat located near or on the site from earlier missions that satisfies the requirement for a short-term habitation for the crew to use while constructing Hexamars-2 or Lavapolis-2. Prefabricated structures and materials will be shipped to the site before the long-term crew members arrive. Partial construction and preparation for the long-term habitat will be done by crew members or robotics from a previous mission. The construction of the long-term base will occur in phases. Hexamars-2 consists of six sphere-shaped inflatable modules that will be partially buried below the Martian surface. The construction of each sphere will occur in ten steps. Shape charges will be used to create the crater in which the spherical structure will be placed. The interior core will be unloaded and put into place followed by the exterior structure. The foundation will be filled, the interior bladder will be inflated, floor-to-floor joists connected, and sand pockets filled. Finally, the life support system and interior partitions are put in place. Each sphere consists of three levels of which the lower level will be safe haven. Particular attention is given to structural support, the dominance of internal pressure, the process of construction, and human factors
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Neuropsychological Test Performance in African-American and White Patients with Alzheimer's Disease
Little information exists on the performance of black versus white patients with Alzheimer's disease on neuropsychological tests for dementia.In this study, we compared performance on the CERAD (Consortium to Establish a Registry for Alzheimer's Disease) neuropsychological battery between white (n equals 830) and black (n equals 158) patients with Alzheimer's disease enrolled in the CERAD study at 23 university medical centers in the United States. The black patients were older, had fewer years of formal education, and were more impaired in their activities of daily living than were the white patients. After controlling for these characteristics and for duration of the disease and severity of dementia, there were differences in the performance of black and white patients on several of the cognitive measures. Black patients scored lower than whites on tests of visual naming and constructional praxis and on the Mini-Mental State Examination. There were no statistical differences in performance on tests of fluency and word list memory. These findings suggest that cultural or experiential differences may modify performance on specific neuropsychological tests. These factors, in addition to age and educational background, should be considered when interpreting performance on neuropsychological tests in elderly black patients with dementia
Dynamic contrast-enhanced magnetic resonance imaging of tumor-induced lymph flow.
The growth of metastatic tumors in mice can result in markedly increased lymph flow through tumor-draining lymph nodes (LNs), which is associated with LN lymphangiogenesis. A dynamic magnetic resonance imaging (MRI) assay was developed, which uses low-molecular weight gadolinium contrast agent to label the lymphatic drainage, to visualize and quantify tumor-draining lymph flow in vivo in mice bearing metastatic melanomas. Tumor-bearing mice showed greatly increased lymph flow into and through draining LNs and into the bloodstream. Quantitative analysis established that both the amount and the rate of lymph flow through draining LNs are significantly increased in melanoma-bearing mice. In addition, the rate of appearance of contrast media in the bloodstream was significantly increased in mice bearing melanomas. These results indicate that gadolinium-based contrast-enhanced MRI provides a noninvasive assay for high-resolution spatial identification and mapping of lymphatic drainage and for dynamic measurement of changes in lymph flow associated with cancer or lymphatic dysfunction in mice. Low-molecular weight gadolinium contrast is already used for 1.5-T MRI scanning in humans, which should facilitate translation of this imaging assay
A computational approach to compare regression modelling strategies in prediction research
Pretreatment CD4 Cell Slope and Progression to AIDS or Death in HIV-Infected Patients Initiating Antiretroviral TherapyโThe CASCADE Collaboration: A Collaboration of 23 Cohort Studies
Analyzing data from several thousand cohort study participants, Marcel Wolbers and colleagues find that the rate of CD4 T cell decline is not useful in deciding when to start HIV treatment
Rapid Identification of Emerging Pathogens: Coronavirus
New surveillance approach can analyze >900 polymerase chain reactions per day
Data-driven approach for creating synthetic electronic medical records
<p>Abstract</p> <p>Background</p> <p>New algorithms for disease outbreak detection are being developed to take advantage of full electronic medical records (EMRs) that contain a wealth of patient information. However, due to privacy concerns, even anonymized EMRs cannot be shared among researchers, resulting in great difficulty in comparing the effectiveness of these algorithms. To bridge the gap between novel bio-surveillance algorithms operating on full EMRs and the lack of non-identifiable EMR data, a method for generating complete and synthetic EMRs was developed.</p> <p>Methods</p> <p>This paper describes a novel methodology for generating complete synthetic EMRs both for an outbreak illness of interest (tularemia) and for background records. The method developed has three major steps: 1) synthetic patient identity and basic information generation; 2) identification of care patterns that the synthetic patients would receive based on the information present in real EMR data for similar health problems; 3) adaptation of these care patterns to the synthetic patient population.</p> <p>Results</p> <p>We generated EMRs, including visit records, clinical activity, laboratory orders/results and radiology orders/results for 203 synthetic tularemia outbreak patients. Validation of the records by a medical expert revealed problems in 19% of the records; these were subsequently corrected. We also generated background EMRs for over 3000 patients in the 4-11 yr age group. Validation of those records by a medical expert revealed problems in fewer than 3% of these background patient EMRs and the errors were subsequently rectified.</p> <p>Conclusions</p> <p>A data-driven method was developed for generating fully synthetic EMRs. The method is general and can be applied to any data set that has similar data elements (such as laboratory and radiology orders and results, clinical activity, prescription orders). The pilot synthetic outbreak records were for tularemia but our approach may be adapted to other infectious diseases. The pilot synthetic background records were in the 4-11 year old age group. The adaptations that must be made to the algorithms to produce synthetic background EMRs for other age groups are indicated.</p
Estimating Long-Term Survival of Critically Ill Patients: The PREDICT Model
BACKGROUND: Long-term survival outcome of critically ill patients is important in assessing effectiveness of new treatments and making treatment decisions. We developed a prognostic model for estimation of long-term survival of critically ill patients. METHODOLOGY AND PRINCIPAL FINDINGS: This was a retrospective linked data cohort study involving 11,930 critically ill patients who survived more than 5 days in a university teaching hospital in Western Australia. Older age, male gender, co-morbidities, severe acute illness as measured by Acute Physiology and Chronic Health Evaluation II predicted mortality, and more days of vasopressor or inotropic support, mechanical ventilation, and hemofiltration within the first 5 days of intensive care unit admission were associated with a worse long-term survival up to 15 years after the onset of critical illness. Among these seven pre-selected predictors, age (explained 50% of the variability of the model, hazard ratio [HR] between 80 and 60 years old = 1.95) and co-morbidity (explained 27% of the variability, HR between Charlson co-morbidity index 5 and 0 = 2.15) were the most important determinants. A nomogram based on the pre-selected predictors is provided to allow estimation of the median survival time and also the 1-year, 3-year, 5-year, 10-year, and 15-year survival probabilities for a patient. The discrimination (adjusted c-index = 0.757, 95% confidence interval 0.745-0.769) and calibration of this prognostic model were acceptable. SIGNIFICANCE: Age, gender, co-morbidities, severity of acute illness, and the intensity and duration of intensive care therapy can be used to estimate long-term survival of critically ill patients. Age and co-morbidity are the most important determinants of long-term prognosis of critically ill patients
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ADVANCED RECIPROCATING COMPRESSION TECHNOLOGY (ARCT)
The U.S. natural gas pipeline industry is facing the twin challenges of increased flexibility and capacity expansion. To meet these challenges, the industry requires improved choices in gas compression to address new construction and enhancement of the currently installed infrastructure. The current fleet of installed reciprocating compression is primarily slow-speed integral machines. Most new reciprocating compression is and will be large, high-speed separable units. The major challenges with the fleet of slow-speed integral machines are: limited flexibility and a large range in performance. In an attempt to increase flexibility, many operators are choosing to single-act cylinders, which are causing reduced reliability and integrity. While the best performing units in the fleet exhibit thermal efficiencies between 90% and 92%, the low performers are running down to 50% with the mean at about 80%. The major cause for this large disparity is due to installation losses in the pulsation control system. In the better performers, the losses are about evenly split between installation losses and valve losses. The major challenges for high-speed machines are: cylinder nozzle pulsations, mechanical vibrations due to cylinder stretch, short valve life, and low thermal performance. To shift nozzle pulsation to higher orders, nozzles are shortened, and to dampen the amplitudes, orifices are added. The shortened nozzles result in mechanical coupling with the cylinder, thereby, causing increased vibration due to the cylinder stretch mode. Valve life is even shorter than for slow speeds and can be on the order of a few months. The thermal efficiency is 10% to 15% lower than slow-speed equipment with the best performance in the 75% to 80% range. The goal of this advanced reciprocating compression program is to develop the technology for both high speed and low speed compression that will expand unit flexibility, increase thermal efficiency, and increase reliability and integrity. Retrofit technologies that address the challenges of slow-speed integral compression are: (1) optimum turndown using a combination of speed and clearance with single-acting operation as a last resort; (2) if single-acting is required, implement infinite length nozzles to address nozzle pulsation and tunable side branch absorbers for 1x lateral pulsations; and (3) advanced valves, either the semi-active plate valve or the passive rotary valve, to extend valve life to three years with half the pressure drop. This next generation of slow-speed compression should attain 95% efficiency, a three-year valve life, and expanded turndown. New equipment technologies that address the challenges of large-horsepower, high-speed compression are: (1) optimum turndown with unit speed; (2) tapered nozzles to effectively reduce nozzle pulsation with half the pressure drop and minimization of mechanical cylinder stretch induced vibrations; (3) tunable side branch absorber or higher-order filter bottle to address lateral piping pulsations over the entire extended speed range with minimal pressure drop; and (4) semi-active plate valves or passive rotary valves to extend valve life with half the pressure drop. This next generation of large-horsepower, high-speed compression should attain 90% efficiency, a two-year valve life, 50% turndown, and less than 0.75 IPS vibration. This program has generated proof-of-concept technologies with the potential to meet these ambitious goals. Full development of these identified technologies is underway. The GMRC has committed to pursue the most promising enabling technologies for their industry
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