Nueva forma de entender las pruebas de condición física en relación con la salud

El objetivo de este trabajo es mostrar una nueva forma de entender la evaluación de la “condición física en relación con la salud”, para evitar la inactividad y el sedentarismo. Los antecedentes se encuentran en las baterías de test utilizadas desde 1976 hasta la actualidad. Se utiliza el concepto de salud de la OMS. Se analizan pruebas con criterios de funcionalidad, economía, validez, fiabilidad y especificidad. Se eligen las siguientes pruebas y se calculan los umbrales: UKK Walk test (P75), 6” en sprint test 20 m (P75), 19 repeticiones en Chair Stand Test(P25), 11 repeticiones Arm Curl Test (P25), -10,5 cm Back Scratch Test (P25), -17,5 cm en Chair Sit and Reach Test. Se propugna la elaboración de una batería de test universal e inclusiva y elaborar percentiles mundiales ayudados por el big dataThe aim of this research was to propose a new way of understanding health-related physical fitness assessment in order to prevent inactivity and sedentarism. The background lies in the test batteries used from 1976 to the present. WHO's health concept was used. Tests were analysed based on functionality, economy, validity, reliability and specificity criteria. The following tests were chosen and the thresholds were calculated: 1,425s in the UKK walk test (P75), 6s in the 20-m sprint test (P75), 19 repetitions in the chair stand test (P25), 11 repetitions in the arm curl test (P25), -10.5cm in the back scratch test (P25), -17.5cm in the chair sit-and-reach test (P25). It was proposed that a universal and inclusive test battery be developed and the percentiles for the world population are determined with the help of big dat

Universal Features of Holographic Anomalies

We study the mechanism by which gravitational actions reproduce the trace anomalies of the holographically related conformal field theories. Two universal features emerge: a) the ratios of type B trace anomalies in any even dimension are independent of the gravitational action, being uniquely determined by the underlying algebraic structure b) the normalization of the type A and the overall normalization of the type B anomalies are given by action dependent expressions with the dimension dependence completely fixed.Comment: 17 pages, harvma

D3-branes on the Coulomb branch and instantons

The relative coefficients of higher derivative interactions of the IIB effective action of the form C^4, (D F_5)^4, F_5^8, ... (where C is the Weyl tensor and F_5 is the five-form field strength) are motivated by supersymmetry arguments. It is shown that the classical supergravity solution for N parallel D3-branes is unaltered by this combination of terms. The non-vanishing of \zeroC^2 in this background (where \zero C is the background value of the Weyl tensor) leads to effective O(1/alpha') interactions, such as C^2 and Lambda^8 (where Lambda is the dilatino). These contain D-instanton contributions in addition to tree and one-loop terms. The near horizon limit of the N D3-brane system describes a multi-AdS_5xS^5 geometry that is dual to \calN=4 SU(N) Yang-Mills theory spontaneously broken to S(U(M_1)x...xU(M_r)). Here, the N D3-branes are grouped into r coincident bunches with M_r in each group, with M_r/N = m_r fixed as N goes to infinity. The boundary correlation function of eight Lambda's is constructed explicitly. The second part of the paper considers effects of a constrained instanton in this large-N Yang-Mills theory by an extension of the analysis of Dorey, Hollowood and Khoze of the one-instanton measure at finite N. This makes precise the correspondence with the supergravity D-instanton measure at leading order in the 1/N expansion. However, the duality between instanton-induced correlation functions in Yang-Mills theory and the dual supergravity is somewhat obscured by complications relating to the structure of constrained instantons.Comment: 30 pages, JHEP style. Typos corrected and minor clarifications adde

Low energy effective action on a self-gravitating D-brane

Recently the study of braneworld on the self-gravitating D-brane has been initiated and derived the gravitational equation on the brane by holographic and geometrical projection methods. Surprisingly, in common with these two methods, the matter on the brane cannot be the source of the gravity on the brane at leading order. In this paper we will propose the low energy effective action on the D-brane coupled with gravity which derives the same results.Comment: 8 pages, minor corrections, accepted for publication in Physical Review

Peroxisome proliferator-activated receptor-β activation restores the high glucose-induced impairment of insulin signaling in endothelial cells

BACKGROUND AND PURPOSE: PPARβ enhances insulin sensitivity in adipocytes and skeletal muscle cells, but its effects on insulin signalling in endothelial cells are not known. We analysed the effects of the PPARβ/δ (PPARβ) agonists, GW0742 and L165041, on impaired insulin signalling induced by high glucose in HUVECs and aortic and mesenteric arteries from diabetic rats. EXPERIMENTAL APPROACH: Insulin-stimulated NO production, Akt-Ser(473) and eNOS-Ser(1177) phosphorylation, and reactive oxygen species (ROS) production were studied in HUVECs incubated in low- or high-glucose medium. Insulin-stimulated relaxations and protein phosphorylation in vessels from streptozotocin (STZ)-induced diabetic rats were also analysed. KEY RESULTS: HUVECs incubated in high-glucose medium showed a significant reduction in insulin-stimulated production of NO. High glucose also reduced insulin-induced Akt-Ser(473) and eNOS-Ser(1177) phosphorylation, increased IRS-1-Ser(636) and ERK1/2-Thr(183)-Tyr(185) phosphorylation and increased ROS production. The co-incubation with the PPARβ agonists GW0742 or L165041 prevented all these effects induced by high glucose. In turn, the effects induced by the agonists were suppressed when HUVEC were also incubated with the PPARβ antagonist GSK0660, the pyruvate dehydrogenase kinase (PDK)4 inhibitor dichloroacetate or after knockdown of both PPARβ and PDK4 with siRNA. The ERK1/2 inhibitor PD98059, ROS scavenger catalase, inhibitor of complex II thenoyltrifluoroacetone or uncoupler of oxidative phosphorylation, carbonyl cyanide m-chlorophenylhydrazone, also prevented glucose-induced insulin resistance. In STZ diabetic rats, oral GW0742 also improved insulin signalling and the impaired NO-mediated vascular relaxation. CONCLUSION AND IMPLICATIONS: PPARβ activation in vitro and in vivo restores the endothelial function, preserving the insulin-Akt-eNOS pathway impaired by high glucose, at least in part, through PDK4 activation

(Sub)mm Interferometry Applications in Star Formation Research

This contribution gives an overview about various applications of (sub)mm interferometry in star formation research. The topics covered are molecular outflows, accretion disks, fragmentation and chemical properties of low- and high-mass star-forming regions. A short outlook on the capabilities of ALMA is given as well.Comment: 20 pages, 7 figures, in proceedings to "2nd European School on Jets from Young Star: High Angular Resolution Observations". A high-resolution version of the paper can be found at http://www.mpia.de/homes/beuther/papers.htm

Brane World Dynamics and Conformal Bulk Fields

In the Randall-Sundrum scenario we investigate the dynamics of a spherically symmetric 3-brane world when matter fields are present in the bulk. To analyze the 5-dimensional Einstein equations we employ a global conformal transformation whose factor characterizes the $Z_2$ symmetric warp. We find a new set of exact dynamical collapse solutions which localize gravity in the vicinity of the brane for a stress-energy tensor of conformal weight -4 and a warp factor that depends only on the coordinate of the fifth dimension. Geometries which describe the dynamics of inhomogeneous dust and generalized dark radiation on the brane are shown to belong to this set. The conditions for singular or globally regular behavior and the static marginally bound limits are discussed for these examples. Also explicitly demonstrated is complete consistency with the effective point of view of a 4-dimensional observer who is confined to the brane and makes the same assumptions about the bulk degrees of freedom.Comment: 26 pages, latex, no figures. Minor revisions. Some references added. Revised version to appear in Phys. Rev.

Dark Radiation Dynamics on the Brane

We investigate the dynamics of a spherically symmetric vaccum on a Randall and Sundrum 3-brane world. Under certain natural conditions, the effective Einstein equations on the brane form a closed system for spherically symmetric dark radiation. We determine exact dynamical and inhomogeneous solutions, which are shown to depend on the brane cosmological constant, on the dark radiation tidal charge and on its initial energy configuration. We identify the conditions defining these solutions as singular or as globally regular. Finally, we discuss the confinement of gravity to the vicinity of the brane and show that a phase transition to a regime where gravity is not bound to the brane may occur at short distances during the collapse of positive dark energy density on a realistic de Sitter brane.Comment: 26 pages, LaTeX, 11 EPS figures. Two references added with some adjustments to the text. Version to appear in Phys. Rev.

Clinical phenotypes of acute heart failure based on signs and symptoms of perfusion and congestion at emergency department presentation and their relationship with patient management and outcomes

Objective To compare the clinical characteristics and outcomes of patients with acute heart failure (AHF) according to clinical profiles based on congestion and perfusion determined in the emergency department (ED). Methods and results Overall, 11 261 unselected AHF patients from 41 Spanish EDs were classified according to perfusion (normoperfusion = warm; hypoperfusion = cold) and congestion (not = dry; yes = wet). Baseline and decompensation characteristics were recorded as were the main wards to which patients were admitted. The primary outcome was 1-year all-cause mortality; secondary outcomes were need for hospitalisation during the index AHF event, in-hospital all-cause mortality, prolonged hospitalisation, 7-day post-discharge ED revisit for AHF and 30-day post-discharge rehospitalisation for AHF. A total of 8558 patients (76.0%) were warm+ wet, 1929 (17.1%) cold+ wet, 675 (6.0%) warm+ dry, and 99 (0.9%) cold+ dry; hypoperfused (cold) patients were more frequently admitted to intensive care units and geriatrics departments, and warm+ wet patients were discharged home without admission. The four phenotypes differed in most of the baseline and decompensation characteristics. The 1-year mortality was 30.8%, and compared to warm+ dry, the adjusted hazard ratios were significantly increased for cold+ wet (1.660; 95% confidence interval 1.400-1.968) and cold+ dry (1.672; 95% confidence interval 1.189-2.351). Hypoperfused (cold) phenotypes also showed higher rates of index episode hospitalisation and in-hospital mortality, while congestive (wet) phenotypes had a higher risk of prolonged hospitalisation but decreased risk of rehospitalisation. No differences were observed among phenotypes in ED revisit risk. Conclusions Bedside clinical evaluation of congestion and perfusion of AHF patients upon ED arrival and classification according to phenotypic profiles proposed by the latest European Society of Cardiology guidelines provide useful complementary information and help to rapidly predict patient outcomes shortly after ED patient arrival

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research