Theoretical survey of tidal-charged black holes at the LHC

We analyse a family of brane-world black holes which solve the effective four-dimensional Einstein equations for a wide range of parameters related to the unknown bulk/brane physics. We first constrain the parameters using known experimental bounds and, for the allowed cases, perform a numerical analysis of their time evolution, which includes accretion through the Earth. The study is aimed at predicting the typical behavior one can expect if such black holes were produced at the LHC. Most notably, we find that, under no circumstances, would the black holes reach the (hazardous) regime of Bondi accretion. Nonetheless, the possibility remains that black holes live long enough to escape from the accelerator (and even from the Earth's gravitational field) and result in missing energy from the detectors.Comment: RevTeX4, 12 pages, 4 figures, 5 tables, minor changes to match the accepted version in JHE

Impaired Axonal Transport in Motor Neurons Correlates with Clinical Prion Disease

Prion diseases are fatal neurodegenerative disorders causing motor dysfunctions, dementia and neuropathological changes such as spongiosis, astroglyosis and neuronal loss. The chain of events leading to the clinical disease and the role of distinct brain areas are still poorly understood. The role of nervous system integrity and axonal properties in prion pathology are still elusive. There is no evidence of both the functional axonal impairments in vivo and their connection with prion disease. We studied the functional axonal impairments in motor neurons at the onset of clinical prion disease using the combination of tracing as a functional assay for axonal transport with immunohistochemistry experiments. Well-established and novel confocal and ultramicroscopy techniques were used to image and quantify labeled neurons. Despite profound differences in the incubation times, 30% to 45% of neurons in the red nucleus of different mouse lines showed axonal transport impairments at the disease onset bilaterally after intracerebral prion inoculation and unilaterally—after inoculation into the right sciatic nerve. Up to 94% of motor cortex neurons also demonstrated transport defects upon analysis by alternative imaging methods. Our data connect axonal transport impairments with disease symptoms for different prion strains and inoculation routes and establish further insight on the development of prion pathology in vivo. The alterations in localization of the proteins involved in the retrograde axonal transport allow us to propose a mechanism of transport disruption, which involves Rab7-mediated cargo attachment to the dynein-dynactin pathway. These findings suggest novel targets for therapeutic and diagnostic approaches in the early stages of prion disease

Black Hole Evaporation and Compact Extra Dimensions

We study the evaporation of black holes in space-times with extra dimensions of size L. We first obtain a description which interpolates between the expected behaviors of very large and very small black holes and then show that the luminosity is greatly damped when the horizon shrinks towards L from a larger value. Analogously, black holes born with an initial size smaller than L are almost stable. This effect is due to the dependence of both the Hawking temperature and the grey-body factor of a black hole on the dimensionality of space. Although the picture of what happens when the horizon becomes of size L is still incomplete, we argue that there occurs a (first order) phase transition, possibly signaled by an outburst of energy which leaves a quasi-stable remnant.Comment: RevTeX, 13 pages, 6 figures include

Matrix Theory Description of Schwarzschild Black Holes in the Regime N >> S

We study the description of Schwarzschild black holes, of entropy S, within matrix theory in the regime $N \ge S \gg 1$. We obtain the most general matrix theory equation of state by requiring that black holes admit a description within this theory. It has a recognisable form in various cases. In some cases a D dimensional black hole can plausibly be thought of as a $\tilde{D} = D + 1$ dimensional black hole, described by another auxiliary matrix theory, but in its $\tilde{N} \sim S$ regime. We find what appears to be a matrix theory generalisation to higher dynamical branes of the normalisation of dynamical string tension, seen in other contexts. We discuss a further possible generalisation of the matrix theory equation of state. In a special case, it is governed by $N^3$ dynamical degrees of freedom.Comment: 22 pages. Latex fil

Holography and trace anomaly: what is the fate of (brane-world) black holes?

The holographic principle relates (classical) gravitational waves in the bulk to quantum fluctuations and the Weyl anomaly of a conformal field theory on the boundary (the brane). One can thus argue that linear perturbations in the bulk of static black holes located on the brane be related to the Hawking flux and that (brane-world) black holes are therefore unstable. We try to gain some information on such instability from established knowledge of the Hawking radiation on the brane. In this context, the well-known trace anomaly is used as a measure of both the validity of the holographic picture and of the instability for several proposed static brane metrics. In light of the above analysis, we finally consider a time-dependent metric as the (approximate) representation of the late stage of evaporating black holes which is characterized by decreasing Hawking temperature, in qualitative agreement with what is required by energy conservation.Comment: 11 pages, 2 figures, a few comments and references added, accepted for publication in Phys. Rev.

Brane-world black holes and the scale of gravity

A particle in four dimensions should behave like a classical black hole if the horizon radius is larger than the Compton wavelength or, equivalently, if its degeneracy (measured by entropy in units of the Planck scale) is large. For spherically symmetric black holes in 4 + d dimensions, both arguments again lead to a mass threshold MC and degeneracy scale Mdeg of the order of the fundamental scale of gravity MG. In the brane-world, deviations from the Schwarzschild metric induced by bulk effects alter the horizon radius and effective four-dimensional Euclidean action in such a way that MC \simeq Mdeg might be either larger or smaller than MG. This opens up the possibility that black holes exist with a mass smaller than MG and might be produced at the LHC even if M>10 TeV, whereas effects due to bulk graviton exchanges remain undetectable because suppressed by inverse powers of MG. Conversely, even if black holes are not found at the LHC, it is still possible that MC>MG and MG \simeq 1TeV.Comment: 4 pages, no figur

Quantum state preparation and macroscopic entanglement in gravitational-wave detectors

Long-baseline laser-interferometer gravitational-wave detectors are operating at a factor of 10 (in amplitude) above the standard quantum limit (SQL) within a broad frequency band. Such a low classical noise budget has already allowed the creation of a controlled 2.7 kg macroscopic oscillator with an effective eigenfrequency of 150 Hz and an occupation number of 200. This result, along with the prospect for further improvements, heralds the new possibility of experimentally probing macroscopic quantum mechanics (MQM) - quantum mechanical behavior of objects in the realm of everyday experience - using gravitational-wave detectors. In this paper, we provide the mathematical foundation for the first step of a MQM experiment: the preparation of a macroscopic test mass into a nearly minimum-Heisenberg-limited Gaussian quantum state, which is possible if the interferometer's classical noise beats the SQL in a broad frequency band. Our formalism, based on Wiener filtering, allows a straightforward conversion from the classical noise budget of a laser interferometer, in terms of noise spectra, into the strategy for quantum state preparation, and the quality of the prepared state. Using this formalism, we consider how Gaussian entanglement can be built among two macroscopic test masses, and the performance of the planned Advanced LIGO interferometers in quantum-state preparation

Searching for a Stochastic Background of Gravitational Waves with LIGO

The Laser Interferometer Gravitational-wave Observatory (LIGO) has performed the fourth science run, S4, with significantly improved interferometer sensitivities with respect to previous runs. Using data acquired during this science run, we place a limit on the amplitude of a stochastic background of gravitational waves. For a frequency independent spectrum, the new limit is $\Omega_{\rm GW} < 6.5 \times 10^{-5}$. This is currently the most sensitive result in the frequency range 51-150 Hz, with a factor of 13 improvement over the previous LIGO result. We discuss complementarity of the new result with other constraints on a stochastic background of gravitational waves, and we investigate implications of the new result for different models of this background.Comment: 37 pages, 16 figure

The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis

Arf assembles a complex containing Miz1, heterochromatin, and histone H3K3 to block expression of genes involved in cell adhesion and signal transduction. The resulting blockade of cell–cell and cell–matrix interactions facilitates elimination of cells carrying oncogenic mutations