How can response art and media choices demystify feelings of helplessness that burden art therapists when reaching a stagnant therapeutic process with the military and veteran populations?

This research paper aims to explore the feelings of helplessness that art therapists can experience when in the beginning of the therapeutic process leads to the gradual and steady accumulation of stagnation with military and veteran populations. As an art therapist-in-training, there was a profound inquisitiveness to fathom and grasp the true meaning behind this subjective and uncanny phenomenon through a heuristic arts-based enquiry. Delivering a discovery to how the feeling of being helpless could bring light to inner and unconscious process, and to find answers on why those feelings were so prominent in the context of this experience. To make sense of the practitioner’s helplessness that arose and to seriously attempt to deepen the understanding of what the impasses truly meant, a total collection of six re created response arts were produced. They referenced themes or moments at which point those feelings ascendancy was at its highest, as they emerged from the apparent immobilization in the art therapeutic process. While assessing the media properties used for those creations and within the timeframe of three weeks, the arts-based research led to an ongoing contemplation procedure and inner dialogues with the six images. This study resulted in facing the “self” head on, as many reflections on the shaping of the trainee’s self-esteem, self-confidence, professional development and dual identities (professional– artist) had shepherded the researcher to take stock of the self-care strategies needed to maintain a healthier life and a more stable practice of the art therapy profession

Encountering competitors reduces clutch size and increases offspring size in a parasitoid with female–female fighting

Understanding the size of clutches produced by only one parent may require a game-theoretic approach: clutch size may affect offspring fitness in terms of future competitive ability. If larger clutches generate smaller offspring and larger adults are more successful in acquiring and retaining resources, clutch size optima should be reduced when the probability of future competitive encounters is higher. We test this using Goniozus nephantidis, a gregarious parasitoid wasp in which the assumption of size-dependent resource acquisition is met via female–female contests for hosts. As predicted, smaller clutches are produced by mothers experiencing competition, due to fewer eggs being matured and to a reduced proportion of matured eggs being laid. As assumed, smaller clutches generate fewer but larger offspring. We believe this is the first direct evidence for pre-ovipositional and game-theoretic clutch size adjustment in response to an intergenerational fitness effect when clutches are produced by a single individual

Indentation modulus and Young\u27s modulus of Cu‐Cr‐Zr alloy at macro‐scale level

In this communication the first experimental results of indentation modulus and Young’s modulus (tensile modulus) of seven samples of Cu-Cr-Zr alloy (chemical composition: 1%Cr, 0.06%Zr, rest Cu), in the macro-scale range at room temperature, are presented and compared. Six Cu-Cr-Zr samples have been aged from different heat treatments for 2 hours in a vacuum furnace at 400C, 480C, 550C, 600C, 650C, 700C, and a single sample is kept as received. In the alloys here investigated, Cr is coherent in the Cu matrix for the as-received condition and the precipitates grow in size up to ~32 nm for the 700C condition. The experimental procedures for the measurement of indentation modulus, by using the primary hardness standard machine at INRIM, and the Young’s modulus, by means of engineering tensile tests at CIRA, are described. Please click Additional Files below to see the full abstract

Characterization of a second open reading frame in genome segment 10 of bluetongue virus

Viruses have often evolved overlapping reading frames in order to maximise their coding capacity. Until recently, the segmented double-stranded (ds) RNA genome of viruses of the Orbivirus genus was thought to be monocistronic but the identification of the bluetongue virus (BTV) NS4 protein changed this assumption. A small open reading frame (ORF) in segment 10, overlapping the NS3 ORF in the +1 position that is maintained in more than 300 strains of the 26 different BTV serotypes and in more of 200 strains of the phylogenetically related African horse sickness (AHSV). In BTV, this ORF (named S10-ORF2 in this study) encodes a putative protein of 50-59 amino acid residues in length and appears to be under a strong positive selection. HA- or GFP-tagged versions of S10-ORF2 expressed from transfected plasmids localised within the nucleoli of transfected cells unless a putative nucleolar localisation signal was mutated S10-ORF2 inhibited gene expression, but not RNA translation, in transient transfection reporter assays. In both mammalian and insect cells, BTV S10-ORF2 deletion mutants (BTV8ΔS10-ORF2) displayed similar replication kinetics to wild type virus. In vivo, S10-ORF2 deletion mutants were pathogenic in mouse models of disease. Although further evidence is required for S10-ORF2 expression during infection, the data presented provide an initial characterisation of this open reading frame

Full thickness epidermal burn from a heating pad on a cesarean incision with silver dressing: a case report

We present a case of a full thickness epidermal burn resulting from an all-natural clay-based heating pad over a cesarean incision silver dressing to bring awareness to the risks associated with nonpharmacologic management of post cesarean pain. There is limited guidance on nonpharmacological management of post cesarean pain. It is important that providers are able to advise their patients about their options, including to be wary of using heating pads on post-cesarean dressings, especially with pain in the early post-partum period

Milestone 3.2 - DiSSCo Digital Maturity Self -Assessment Tool - Design Blueprint

This Milestone 3.2 report for DiSSCo Prepare Work Package 3 Task 3.1 sets out the initial design blueprint for a DiSSCo Digital Maturity Self-Assessment Tool, building on the analyses in the Milestone 3.1 report ‘Improving Digital Capability - Case Studies and Analysis’ (Hardy et al, Dec 2020) and in the Milestone 3.3. Report, including consideration of two existing tools in our sector. This tool is intended to support teams, institutions and national nodes in developing organisational readiness for provision of the DiSSCo services and data, helping them to identify and target areas for improvement. The aim is for this to tie in to future provision of training and support, as well as helping to identify the gaps at aggregate level where that training may be most useful. In addition , we believe there is a case for a platform that can support both this and the related Task 7.3 Policy Tool, such that these or other tools are consistent for users and can interact with one another where relevant, avoiding any duplication. This blueprint is intended for wider discussion among the DiSSCo members, so that tool content can be developed in more detail as part of the Deliverable for this Taskinfo:eu-repo/semantics/publishedVersio

Negative mood induction increases choice of heroin versus food pictures in opiate-dependent individuals: Correlation with self-medication coping motives and subjective reactivity

This is the final version. Available from Frontiers Media via the DOI in this record.Acute growth in negative affect is thought to play a major role in triggering relapse in opiate-dependent individuals. Consistent with this view, three lab studies have demonstrated that negative mood induction increases opiate craving in opiate-dependent individuals. The current study sought to confirm these effects with a behavioral measure of heroin seeking, and test whether the effect is associated with self-reported opiate use to cope with negative affect and subjective reactivity to mood induction. Participants were heroin-dependent individuals engaged with treatment services (n = 47) and control participants (n = 25). Heroin users completed a questionnaire assessing reasons for using heroin: negative affect, social pressure, and cued craving. Baseline heroin choice was measured by preference to enlarge heroin versus food thumbnail pictures in two-alternative forced-choice trials. Negative mood was then induced by depressive statements and music before heroin choice was tested again. Subjective reactivity was indexed by negative and positive mood reported at the pre-induction to post-test timepoints. Heroin users chose heroin images more frequently than controls overall (p = .001) and showed a negative mood-induced increase in heroin choice compared to control participants (interaction p < .05). Mood-induced heroin choice was associated with self-reported heroin use to cope with negative affect (p < .05), but not social pressure (p = .39) or cued craving (p = .52), and with subjective mood reactivity (p = .007). These data suggest that acute negative mood is a trigger for heroin seeking in heroin-dependent individuals, and this effect is pronounced in those who report using heroin to cope with negative affect, and those who show greater subjective reactivity to negative triggers. Interventions should seek to target negative coping motives to build resilience to affective triggers for relapse.Alcohol Research U

KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences.

BACKGROUND: Transposable element-embedded regulatory sequences (TEeRS) and their KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as modulators of gene expression. We aim to characterize the contribution of this system to gene regulation in early human development and germ cells. RESULTS: Here, after studying genes driven by the long terminal repeat (LTR) of endogenous retroviruses, we identify the ape-restricted ZNF676 as the sequence-specific repressor of a subset of contemporary LTR12 integrants responsible for a large fraction of transpochimeric gene transcripts (TcGTs) generated during human early embryogenesis. We go on to reveal that the binding of this KZFP correlates with the epigenetic marking of these TEeRS in the germline, and is crucial to the control of genes involved in ciliogenesis/flagellogenesis, a biological process that dates back to the last common ancestor of eukaryotes. CONCLUSION: These results illustrate how KZFPs and their TE targets contribute to the evolutionary turnover of transcription networks and participate in the transgenerational inheritance of epigenetic traits

Reactogenicity, safety and antibody response, after one and two doses of mRNA-1273 in seronegative and seropositive healthcare workers

SCOPUS: le.jinfo:eu-repo/semantics/publishe