Evaluation of moire techniques for wind tunnel metrology

The development of a moire technique suitable for the analysis of object deflections in a cryogenically cooled, transonic wind tunnel is described. The operating environment for the wind tunnel has a temperature range of 77 to 3390 k, pressure to 91390 Kgs/sq m, and noise to 150 dB SPL. Efforts were made to accomplish the following: to demonstrate projection moire as it would be used to study structural deflections; to use optical processing to multiply the sensitivity of the moire; and to investigate a system design based on the requirements of the wind tunnel geometry

Perceptions of healthy eating and physical activity in an ethnically diverse sample of young children and their parents: the DEAL prevention of obesity study

Background: Ethnicity is a consistent correlate of obesity; however, little is known about the perceptions and beliefs that may influence engagement with obesity prevention programmes among ethnic minority children. Barriers to (and facilitators of) healthy lifestyles were examined in the qualitative arm of the London (UK) DiEt and Active Living (DEAL) study. Methods: Children aged 8–13 years and their parents, from diverse ethnic groups, were recruited through schools and through places of worship. Thirteen focus group sessions were held with 70 children (n = 39 girls) and eight focus groups and five interviews with 43 parents (n = 34 mothers). Results: Across ethnic groups, dislike of school meals, lack of knowledge of physical activity guidelines for children and negativity towards physical education at school among girls, potentially hindered healthy living. Issues relating to families' wider neighbourhoods (e.g. fast food outlets; lack of safety) illustrated child and parental concerns that environments could thwart intentions for healthy eating and activity. By contrast, there was general awareness of key dietary messages and an emphasis on dietary variety and balance. For ethnic minorities, places of worship were key focal points for social support. Discourse around the retention of traditional practices, family roles and responsibilities, and religion highlighted both potential facilitators (e.g. the importance of family meals) and barriers (reliance on convenience stores for traditional foods). Socio-economic circumstances intersected with key themes, within and between ethnic groups. Conclusions: Several barriers to (and facilitators of) healthy lifestyles were common across ethnic groups. Diversity of cultural frameworks not only were more nuanced, but also shaped lifestyles for minority children.</p

Strategies to improve retention in randomised trials: a Cochrane systematic review and meta-analysis

Objective: To quantify the effect of strategies to improve retention in randomised trials.&lt;p&gt;&lt;/p&gt; Design: Systematic review and meta-analysis.&lt;p&gt;&lt;/p&gt; Data sources Sources searched: MEDLINE, EMBASE, PsycINFO, DARE, CENTRAL, CINAHL, C2-SPECTR, ERIC, PreMEDLINE, Cochrane Methodology Register, Current Controlled Trials metaRegister, WHO trials platform, Society for Clinical Trials (SCT) conference proceedings and a survey of all UK clinical trial research units.&lt;p&gt;&lt;/p&gt; Review: methods Included trials were randomised evaluations of strategies to improve retention embedded within host randomised trials. The primary outcome was retention of trial participants. Data from trials were pooled using the fixed-effect model. Subgroup analyses were used to explore the heterogeneity and to determine whether there were any differences in effect by the type of strategy.&lt;p&gt;&lt;/p&gt; Results: 38 retention trials were identified. Six broad types of strategies were evaluated. Strategies that increased postal questionnaire responses were: adding, that is, giving a monetary incentive (RR 1.18; 95% CI 1.09 to 1.28) and higher valued incentives (RR 1.12; 95% CI 1.04 to 1.22). Offering a monetary incentive, that is, an incentive given on receipt of a completed questionnaire, also increased electronic questionnaire response (RR 1.25; 95% CI 1.14 to 1.38). The evidence for shorter questionnaires (RR 1.04; 95% CI 1.00 to 1.08) and questionnaires relevant to the disease/condition (RR 1.07; 95% CI 1.01 to 1.14) is less clear. On the basis of the results of single trials, the following strategies appeared effective at increasing questionnaire response: recorded delivery of questionnaires (RR 2.08; 95% CI 1.11 to 3.87); a ‘package’ of postal communication strategies (RR 1.43; 95% CI 1.22 to 1.67) and an open trial design (RR 1.37; 95% CI 1.16 to 1.63). There is no good evidence that the following strategies impact on trial response/retention: adding a non-monetary incentive (RR=1.00; 95% CI 0.98 to 1.02); offering a non-monetary incentive (RR=0.99; 95% CI 0.95 to 1.03); ‘enhanced’ letters (RR=1.01; 95% CI 0.97 to 1.05); monetary incentives compared with offering prize draw entry (RR=1.04; 95% CI 0.91 to 1.19); priority postal delivery (RR=1.02; 95% CI 0.95 to 1.09); behavioural motivational strategies (RR=1.08; 95% CI 0.93 to 1.24); additional reminders to participants (RR=1.03; 95% CI 0.99 to 1.06) and questionnaire question order (RR=1.00, 0.97 to 1.02). Also based on single trials, these strategies do not appear effective: a telephone survey compared with a monetary incentive plus questionnaire (RR=1.08; 95% CI 0.94 to 1.24); offering a charity donation (RR=1.02, 95% CI 0.78 to 1.32); sending sites reminders (RR=0.96; 95% CI 0.83 to 1.11); sending questionnaires early (RR=1.10; 95% CI 0.96 to 1.26); longer and clearer questionnaires (RR=1.01, 0.95 to 1.07) and participant case management by trial assistants (RR=1.00; 95% CI 0.97 to 1.04).&lt;p&gt;&lt;/p&gt; Conclusions: Most of the trials evaluated questionnaire response rather than ways to improve participants return to site for follow-up. Monetary incentives and offers of monetary incentives increase postal and electronic questionnaire response. Some strategies need further evaluation. Application of these results would depend on trial context and follow-up procedures.&lt;p&gt;&lt;/p&gt

Constraints on the Growth and Spin of the Supermassive Black Hole in M32 From High Cadence Visible Light Observations

We present 1-second cadence observations of M32 (NGC221) with the CHIMERA instrument at the Hale 200-inch telescope of the Palomar Observatory. Using field stars as a baseline for relative photometry, we are able to construct a light curve of the nucleus in the g-prime and r-prime band with 1sigma=36 milli-mag photometric stability. We derive a temporal power spectrum for the nucleus and find no evidence for a time-variable signal above the noise as would be expected if the nuclear black hole were accreting gas. Thus, we are unable to constrain the spin of the black hole although future work will use this powerful instrument to target more actively accreting black holes. Given the black hole mass of (2.5+/-0.5)*10^6 Msun inferred from stellar kinematics, the absence of a contribution from a nuclear time-variable signal places an upper limit on the accretion rate which is 4.6*10^{-8} of the Eddington rate, a factor of two more stringent than past upper limits from HST. The low mass of the black hole despite the high stellar density suggests that the gas liberated by stellar interactions was primarily at early cosmic times when the low-mass black hole had a small Eddington luminosity. This is at least partly driven by a top-heavy stellar initial mass function at early cosmic times which is an efficient producer of stellar mass black holes. The implication is that supermassive black holes likely arise from seeds formed through the coalescence of 3-100 Msun mass black holes that then accrete gas produced through stellar interaction processes.Comment: 8 pages, 3 figures, submitted to the Astrophysical Journal, comments welcom

High Energy Neutrinos and Photons from Curvature Pions in Magnetars

We discuss the relevance of the curvature radiation of pions in strongly magnetized pulsars or magnetars, and their implications for the production of TeV energy neutrinos detectable by cubic kilometer scale detectors, as well as high energy photons.Comment: 19 pages, 4 figures, to appear in JCA

Exploring childhood obesity prevention among diverse ethnic groups in schools and places of worship: recruitment, acceptability and feasibility of data collection and intervention components

Small-scale, detailed exploration of the recruitment, assessment, and evaluation processes of obesity intervention among minority ethnic children. The study took place in schools and places of worship during 2008-2010 in London, UK. Measures included 3-day food diaries, 24 hour dietary recalls, the Youth Physical Activity Questionnaire, accelerometry, and diet and physical activity self-efficacy questionnaires. Potential intervention components were evaluated via observation, questionnaires, and focus group discussions. Schools and places of worship that reflected the ethnic and religious diversity of inner city London populations (Hindus, Muslims and Christians) were targeted. Telephone invitations to 12 schools achieved recruitment of five schools (42% response); 181 invitations to 94 places of worship, recruited eight organisations (9%). Multi-strategy approaches were required to build relationships with faith organisations. Sixty-five children aged 8-13 years participated in the testing of measures. High completion rates were achieved for 24 hour recalls, diet and PA self-efficacy questionnaires (ranging from 89% to 100%), with more consistent quality in schools. Dietary assessment highlighted inadequacies in composition data for minority ethnic foods. Intervention sessions were tested among 155 children in all five schools, and 33 children in a church, temple and mosque. Evaluation coverage was more consistent in these places of worship than in schools. Schools may logistically be more straightforward settings for delivery of interventions but, despite complex issues (engagement strategies; cultural foodways), places of worship provide opportunities for effective reach of children, families and communities. We suggest community based participatory research between researchers, schools and community organisations to harness culturally-specific support

Use of strategies to improve retention in primary care randomised trials: a qualitative study with in-depth interviews

Objective To explore the strategies used to improve retention in primary care randomised trials.&lt;p&gt;&lt;/p&gt; Design Qualitative in-depth interviews and thematic analysis.&lt;p&gt;&lt;/p&gt; Participants 29 UK primary care chief and principal investigators, trial managers and research nurses.&lt;p&gt;&lt;/p&gt; Methods In-depth face-to-face interviews.&lt;p&gt;&lt;/p&gt; Results Primary care researchers use incentive and communication strategies to improve retention in trials, but were unsure of their effect. Small monetary incentives were used to increase response to postal questionnaires. Non-monetary incentives were used although there was scepticism about the impact of these on retention. Nurses routinely used telephone communication to encourage participants to return for trial follow-up. Trial managers used first class post, shorter questionnaires and improved questionnaire designs with the aim of improving questionnaire response. Interviewees thought an open trial design could lead to biased results and were negative about using behavioural strategies to improve retention. There was consensus among the interviewees that effective communication and rapport with participants, participant altruism, respect for participant's time, flexibility of trial personnel and appointment schedules and trial information improve retention. Interviewees noted particular challenges with retention in mental health trials and those involving teenagers.&lt;p&gt;&lt;/p&gt; Conclusions The findings of this qualitative study have allowed us to reflect on research practice around retention and highlight a gap between such practice and current evidence. Interviewees describe acting from experience without evidence from the literature, which supports the use of small monetary incentives to improve the questionnaire response. No such evidence exists for non-monetary incentives or first class post, use of which may need reconsideration. An exploration of barriers and facilitators to retention in other research contexts may be justified.&lt;p&gt;&lt;/p&gt

Improving the economic value of photographic screening for optical coherence tomography-detectable macular oedema : a prospective, multicentre, UK study

Peer reviewedPublisher PD

The Contribution of Blazars to the Extragalactic Diffuse Gamma-ray Background and Their Future Spatial Resolution

We examine the constraints on the luminosity-dependent density evolution model for the evolution of blazars given the observed spectrum of the diffuse gamma-ray background (DGRB), blazar source-count distribution, and the blazar spectral energy distribution sequence model, which relates the observed the blazar spectrum to its luminosity. We show that the DGRB observed by the Large Area Telescope (LAT) aboard the Fermi Gamma Ray Space Telescope can be produced entirely by gamma-ray emission from blazars and nonblazar active galactic nuclei, and that our blazar evolution model is consistent with and constrained by the spectrum of the DGRB and flux source-count distribution function of blazars observed by Fermi-LAT. Our results are consistent with previous work that used EGRET spectral data to forecast the Fermi-LAT DGRB. The model includes only three free parameters, and forecasts that >~ 95% of the flux from blazars will be resolved into point sources by Fermi-LAT with 5 years of observation, with a corresponding reduction of the flux in the DGRB by a factor of ~2 to 3 (95% confidence level), which has implications for the Fermi-LAT's sensitivity to dark matter annihilation photons.Comment: 13 pages, 7 figures; v3: minor changes, matches version to appear in Phys. Rev.