Release of mercury from Rocky Mountain forest fires

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95324/1/gbc1338.pd

Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma

Abstract: The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning algorithm to identify cancer genes in individual patients considering all types of damaging alterations simultaneously. Analysing 261 EACs from the OCCAMS Consortium, we discover helper genes that, alongside well-known drivers, promote cancer. We confirm the robustness of our approach in 107 additional EACs. Unlike recurrent alterations of known drivers, these cancer helper genes are rare or patient-specific. However, they converge towards perturbations of well-known cancer processes. Recurrence of the same process perturbations, rather than individual genes, divides EACs into six clusters differing in their molecular and clinical features. Experimentally mimicking the alterations of predicted helper genes in cancer and pre-cancer cells validates their contribution to disease progression, while reverting their alterations reveals EAC acquired dependencies that can be exploited in therapy

Writing settlement after Idle No More: non-indigenous responses in Anglo-Canadian poetry

This article examines the representation of settlement in Canada in the wake of Idle No More in recent Anglo-Canadian literature. It argues that Idle No More engendered a new vocabulary for settler-invader citizens to position themselves in relation to this Indigenous movement, with non-Indigenous Canadians self-identifying as “settlers” and “allies” as a means of both orienting themselves with respect to Indigenous resistance to the settler-invader nation-state and signalling an attempted solidarity with Idle No More that would not lapse into appropriation. Four very different poetic texts by non-Indigenous authors demonstrate this reconsideration of settlement in the wake of Idle No More: Arleen Paré’s Lake of Two Mountains (2014); Rachel Zolf’s Janey’s Arcadia (2014); Rita Wong’s undercurrent (2015); and Shane Rhodes’s X (2013). Although only the latter two of these collections make explicit reference to Idle No More, all four of these texts engage with historical and current colonialisms, relationships to land and water, and relationships between Indigenous peoples and settler-invaders, providing examples of new understandings and representations of (neo)colonial settlement in post-Idle No More Canada

Quiet No More : New Political Activism in Canada and Around the Globe

Spontaneous and creative protest movements have burst onto the political stage in Canada and around the world. Joel D. Harden, an activist, writer, and educator, offers a ground-level account of the most important of these recent expressions of large-scale political engagement, mostly by young people. Based on first-hand accounts from many of the participants and organizers, Harden describes key events and turning-points -- in Canada and beyond -- from the viewpoint of a committed insider

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.

Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior and attention-deficit/hyperactivity disorder, are collectively referred to as externalizing and have shared genetic liability. We applied a multivariate approach that leverages genetic correlations among externalizing traits for genome-wide association analyses. By pooling data from ~1.5 million people, our approach is statistically more powerful than single-trait analyses and identifies more than 500 genetic loci. The loci were enriched for genes expressed in the brain and related to nervous system development. A polygenic score constructed from our results predicts a range of behavioral and medical outcomes that were not part of genome-wide analyses, including traits that until now lacked well-performing polygenic scores, such as opioid use disorder, suicide, HIV infections, criminal convictions and unemployment. Our findings are consistent with the idea that persistent difficulties in self-regulation can be conceptualized as a neurodevelopmental trait with complex and far-reaching social and health correlates

Discordant results between conventional newborn screening and genomic sequencing in the BabySeq Project

Abstract Purpose Newborn screening (NBS) is performed to identify neonates at risk for actionable, severe, early-onset disorders, many of which are genetic. The BabySeq Project randomized neonates to receive conventional NBS or NBS plus exome sequencing (ES) capable of detecting sequence variants that may also diagnose monogenic disease or indicate genetic disease risk. We therefore evaluated how ES and conventional NBS results differ in this population. Methods We compared results of NBS (including hearing screens) and ES for 159 infants in the BabySeq Project. Infants were considered "NBS positive" if any abnormal result was found indicating disease risk and "ES positive" if ES identified a monogenic disease risk or a genetic diagnosis. Results Most infants (132/159, 84%) were NBS and ES negative. Only one infant was positive for the same disorder by both modalities. Nine infants were NBS positive/ES negative, though seven of these were subsequently determined to be false positives. Fifteen infants were ES positive/NBS negative, all of which represented risk of genetic conditions that are not included in NBS programs. No genetic explanation was identified for eight infants referred on the hearing screen. Conclusion These differences highlight the complementarity of information that may be gleaned from NBS and ES in the newborn period