Simulation of sea-state sequences

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The present PhD study, in its first part, uses artificial neural networks (ANNs), an optimization technique called simulated annealing, and statistics to simulate the significant wave height (Hs) and mean zero-up-crossing period ( ) of 3-hourly sea-states of a location in the North East Pacific using a proposed distribution called hepta-parameter spline distribution for the conditional distribution of Hs or given some inputs. Two different seven- network sets of ANNs for the simulation and prediction of Hs and were trained using 20-year observed Hs’s and ’s. The preceding Hs’s and ’s were the most important inputs given to the networks, but the starting day of the simulated period was also necessary. However, the code replaced the day with the corresponding time and the season. The networks were trained by a simulated annealing algorithm and the outputs of the two sets of networks were used for calculating the parameters of the probability density function (pdf) of the proposed hepta-parameter distribution. After the calculation of the seven parameters of the pdf from the network outputs, the Hs and of the future sea-state is predicted by generating random numbers from the corresponding pdf. In another part of the thesis, vertical piles have been studied with the goal of identifying the range of sea-states suitable for the safe pile driving operation. Pile configuration including the non-linear foundation and the gap between the pile and the pile sleeve shims were modeled using the finite elements analysis facilities within ABAQUS. Dynamic analyses of the system for a sea-state characterized by Hs and and modeled as a combination of several wave components were performed. A table of safe and unsafe sea-states was generated by repeating the analysis for various sea-states. If the prediction for a particular sea-state is repeated N times of which n times prove to be safe, then it could be said that the predicted sea-state is safe with the probability of 100(n/N). The last part of the thesis deals with the Hs return values. The return value is a widely used measure of wave extremes having an important role in determining the design wave used in the design of maritime structures. In this part, Hs return value was calculated demonstrating another application of the above simulation of future 3-hourly Hs’s. The maxima method for calculating return values was applied in such a way that avoids the conventional need for unrealistic assumptions. The significant wave height return value has also been calculated using the convolution concept from a model presented by Anderson et al. (2001)

Solution to IDA-PBC PDEs by Pfaffian Differential Equations

Finding the general solution of partial differential equations (PDEs) is essential for controller design in some methods. Interconnection and damping assignment passivity based control (IDA-PBC) is one of such methods in which the solution to corresponding PDEs is needed to apply it in practice. In this paper, such PDEs are transformed to corresponding Pfaffian differential equations. Furthermore, it is shown that upon satisfaction of the integrability condition, the solution to the corresponding third order Pfaffian differential equation may be obtained quite easily. The method is applied to the PDEs of IDA-PBC in some benchmark problems such as Magnetic levitation system, Pendubot and underactuated cable driven robot to verify its applicability

Difficulties of Diagnosing Alzheimer's Disease: The Application of Clinical Decision Support Systems

Introduction: Alzheimer's disease is one of the most common causes of dementia, which gradually causes cognitive impairment. Diagnosis of Alzheimer's disease is a complicated process performed through several tests and examinations. Design and development of Clinical Decision Support System (CDSS) could be an appropriate approach for eliminating the existing difficulties of diagnosing Alzheimer's disease. Materials and Methods: This study reviews the current problems in the diagnosis of Alzheimer's disease with an approach to the application of CDSS. The study reviewed the articles published from 1990 to 2016. The articles were identified by searching electronic databases such as PubMed, Google Scholar, Science Direct. Considering the relevance of articles with the objectives of the study, 29 papers were selected. According to the performed investigations, various reasons cause difficulty in Alzheimer's diagnosis. Results: The complexity of diagnostic process and  the similarity of Alzheimer's disease with other causes of dementia are the most important of them. The results of studies about the application of CDSSs on Alzheimer's disease diagnosis indicated that the implementation of these systems could help to eliminate the existing difficulties in the diagnosis of Alzheimer's disease. Conclusion: Developing CDSSs based on diagnostic guidelines could be regarded as one of the possible approaches towards early and accurate diagnosis of Alzheimer's disease. Applying of computer-interpretable guideline (CIG) models such as GLIF, PROforma, Asbru, and EON can help to design CDSS with the capability of minimizing the burden of diagnostic problems with Alzheimer's disease

Neural network based simulation of sea-state sequences

The present PhD study, in its first part, uses artificial neural networks (ANNs), an optimization technique called simulated annealing, and statistics to simulate the significant wave height (Hs) and mean zero-up-crossing period ( ) of 3-hourly sea-states of a location in the North East Pacific using a proposed distribution called hepta-parameter spline distribution for the conditional distribution of Hs or given some inputs. Two different seven- network sets of ANNs for the simulation and prediction of Hs and were trained using 20-year observed Hs’s and ’s. The preceding Hs’s and ’s were the most important inputs given to the networks, but the starting day of the simulated period was also necessary. However, the code replaced the day with the corresponding time and the season. The networks were trained by a simulated annealing algorithm and the outputs of the two sets of networks were used for calculating the parameters of the probability density function (pdf) of the proposed hepta-parameter distribution. After the calculation of the seven parameters of the pdf from the network outputs, the Hs and of the future sea-state is predicted by generating random numbers from the corresponding pdf. In another part of the thesis, vertical piles have been studied with the goal of identifying the range of sea-states suitable for the safe pile driving operation. Pile configuration including the non-linear foundation and the gap between the pile and the pile sleeve shims were modeled using the finite elements analysis facilities within ABAQUS. Dynamic analyses of the system for a sea-state characterized by Hs and and modeled as a combination of several wave components were performed. A table of safe and unsafe sea-states was generated by repeating the analysis for various sea-states. If the prediction for a particular sea-state is repeated N times of which n times prove to be safe, then it could be said that the predicted sea-state is safe with the probability of 100(n/N)%. The last part of the thesis deals with the Hs return values. The return value is a widely used measure of wave extremes having an important role in determining the design wave used in the design of maritime structures. In this part, Hs return value was calculated demonstrating another application of the above simulation of future 3-hourly Hs’s. The maxima method for calculating return values was applied in such a way that avoids the conventional need for unrealistic assumptions. The significant wave height return value has also been calculated using the convolution concept from a model presented by Anderson et al. (2001).EThOS - Electronic Theses Online ServiceGBUnited Kingdo

The mathematical relationship among normal patellar dimensions, to find the pre-diseased patellar thickness in different populations

Whether resurfacing or not resurfacing the patella during total knee arthroplasty (TKA) still is a challenge to orthopedic surgeons. A significant reason for this controversy is the far from perfect outcomes of both techniques, resulting from inadequate knowledge of normal patellar dimensions in a diseased one. The primary purpose of the current study is to find the pre-diseased patellar dimensions and the ethnic differences in patellar dimensions. We measured the patella\u27s dimensions on 927 normal young adult knee MRIs from seven different ethnicities. Besides comparing the dimensions between sexes, ages, and sides, we analyzed the differences among ethnic groups. The average thickness was 25.12±2.33 mm; the average width was 44.57±4.32 mm, the average articular surface length was 32.69±3.75 mm, with significant gender, age, and ethnic differences. There were also significant differences in dimensions among ethnic groups, except for between the Indians and Far Eastern Asians and between the Arabs and North Africans. We could also find a robust mathematical relationship between the patella\u27s width, length, and thickness. The ethnic differences in patellar dimensions found in this study can help optimize surgical technique and implant designs for patellar resurfacing. The mathematical equation will help the surgeons find the normal, pre-diseased patella thickness to prevent over-or understuffing during the patellar resurfacing

Induction of antitumor immunity through xenoplacental immunization

Historically cancer vaccines have yielded suboptimal clinical results. We have developed a novel strategy for eliciting antitumor immunity based upon homology between neoplastic tissue and the developing placenta. Placenta formation shares several key processes with neoplasia, namely: angiogenesis, activation of matrix metalloproteases, and active suppression of immune function. Immune responses against xenoantigens are well known to break self-tolerance. Utilizing xenogeneic placental protein extracts as a vaccine, we have successfully induced anti-tumor immunity against B16 melanoma in C57/BL6 mice, whereas control xenogeneic extracts and B16 tumor extracts where ineffective, or actually promoted tumor growth, respectively. Furthermore, dendritic cells were able to prime tumor immunity when pulsed with the placental xenoantigens. While vaccination-induced tumor regression was abolished in mice depleted of CD4 T cells, both CD4 and CD8 cells were needed to adoptively transfer immunity to naïve mice. Supporting the role of CD8 cells in controlling tumor growth are findings that only freshly isolated CD8 cells from immunized mice were capable of inducing tumor cell caspases-3 activation ex vivo. These data suggest feasibility of using xenogeneic placental preparations as a multivalent vaccine potently targeting not just tumor antigens, but processes that are essential for tumor maintenance of malignant potential