An Investigation of Real-Time Active Noise Control for 10 kV Substation Noise Suppression

Substation noise is a crucial factor that influences residents’ quality of life, especially in the densely residential areas. Despite small- and medium-sized transformer facilities having relatively low noise levels, due to their proximity to residential areas, they generate considerable annoyance, rendering them a focal point among environmental noise complaints. The predominant noise emitted by these facilities falls within the medium- and low-frequency spectrum range, and the conventional passive noise reduction techniques exhibit limited efficacy in attenuating such low-frequency noise. This study develops a real-time active noise control (ANC) system based on a digital signal processor, TMS320F28335, and various ANC methods, including Filtered-X Least Mean Squares (FxLMS), Normalized Filter-X Least Mean Squares (FxNLMS), and variable step-size FxLMS (VS-FxLMS), are evaluated for the low-frequency noise reduction. In addition, the substation noises at a residential community are measured, analyzed, and used as noise source together with a series of sinusoidal waves for evaluation of the ANC algorithms. Results show the ANC system are effective in attenuating most low-frequency noises (within 600 Hz) and the average noise reduction for the substation noises has achieved by more than 12 dB

Biodegradable Metal Complex-Gated Organosilica for Dually Enhanced Chemodynamic Therapy through GSH Depletions and NIR Light-Triggered Photothermal Effects

Hollow silica spheres have been widely studied for drug delivery because of their excellent biosecurity and high porosity. However, difficulties with degradation in the tumor microenvironment (TME) and premature leaking during drug delivery limit their clinical applications. To alleviate these problems, herein, hollow organosilica spheres (HOS) were initially prepared using a “selective etching strategy” and loaded with a photothermal drug: new indocyanine green (IR820). Then, the Cu2+–tannic acid complex (Cu-TA) was deposited on the surface of the HOS, and a new nanoplatform named HOS@IR820@Cu-TA (HICT) was finally obtained. The deposition of Cu-TA can gate the pores of HOS completely to prevent the leakage of IR820 and significantly enhance the loading capacity of HOS. Once in the mildly acidic TME, the HOS and outer Cu-TA decompose quickly in response, resulting in the release of Cu2+ and IR820. The released Cu2+ can react with the endogenous glutathione (GSH) to consume it and produce Cu+, leading to the enhanced production of highly toxic ·OH through a Fenton-like reaction due to the overexpressed H2O2 in the TME. Meanwhile, the ·OH generation was remarkably enhanced by the NIR light-responsive photothermal effect of IR820. These collective properties of HICT enable it to be a smart nanomedicine for dually enhanced chemodynamic therapy through GSH depletions and NIR light-triggered photothermal effects

Comprehensive assessment of 11 de novo HiFi assemblers on complex eukaryotic genomes and metagenomes.

Pacific Biosciences (PacBio) HiFi sequencing technology generates long reads (>10 kbp) with very high accuracy (<0.01% sequencing error). Although several de novo assembly tools are available for HiFi reads, there are no comprehensive studies on the evaluation of these assemblers. We evaluated the performance of 11 de novo HiFi assemblers on (1) real data for three eukaryotic genomes; (2) 34 synthetic data sets with different ploidy, sequencing coverage levels, heterozygosity rates, and sequencing error rates; (3) one real metagenomic data set; and (4) five synthetic metagenomic data sets with different composition abundance and heterozygosity rates. The 11 assemblers were evaluated using quality assessment tool (QUAST) and benchmarking universal single-copy ortholog (BUSCO). We also used several additional criteria, namely, completion rate, single-copy completion rate, duplicated completion rate, average proportion of largest category, average distance difference, quality value, run-time, and memory utilization. Results show that hifiasm and hifiasm-meta should be the first choice for assembling eukaryotic genomes and metagenomes with HiFi data. We performed a comprehensive benchmarking study of commonly used assemblers on complex eukaryotic genomes and metagenomes. Our study will help the research community to choose the most appropriate assembler for their data and identify possible improvements in assembly algorithms