Stratigraphic hierarchy and three‐dimensional evolution of an exhumed submarine slope channel system

Submarine slope channel systems have complicated three‐dimensional geometries and facies distributions, which are challenging to resolve using subsurface data. Outcrop analogues can provide sub‐seismic‐scale detail, although most exhumed systems only afford two‐dimensional constraints on the depositional architecture. A rare example of an accessible fine‐grained slope channel complex set situated in a tectonically quiescent basin that offers seismic‐scale, down‐dip and across‐strike exposures is the Klein Hangklip area, Tanqua‐Karoo Basin, South Africa. This study investigates the three‐dimensional architecture of this channel complex set to characterise the stratigraphic evolution of a submarine channel‐fill and the implications this has for both sediment transport to the deep‐oceans and reservoir quality distribution. Correlated sedimentary logs and mapping of key surfaces across a 3 km2 area reveal that: (i) the oldest channel elements in channel complexes infill relatively deep channel cuts and have low aspect‐ratios. Later channel elements are bound by comparatively flat erosion surfaces and have high aspect‐ratios; (ii) facies changes across depositional strike are consistent and predictable; conversely, facies change in successive down depositional dip positions indicating longitudinal variability in depositional processes; (iii) stratigraphic architecture is consistent and predictable at seismic‐scale both down‐dip and across‐strike in three‐dimensions; (iv) channel‐base‐deposits exhibit spatial heterogeneity on one to hundreds of metres length‐scales, which can inhibit accurate recognition and interpretations drawn from one‐dimensional or limited two‐dimensional datasets; and (v) channel‐base‐deposit character is linked to sediment bypass magnitude and longevity, which suggests that time‐partitioning is biased towards conduit excavation and maintenance rather than the fill‐phase. The data provide insights into the stratigraphic evolution and architecture of slope channel‐fills on fine‐grained continental margins and can be utilised to improve predictions derived from lower resolution and one‐dimensional well data

Epistasis not needed to explain low dN/dS

An important question in molecular evolution is whether an amino acid that occurs at a given position makes an independent contribution to fitness, or whether its effect depends on the state of other loci in the organism's genome, a phenomenon known as epistasis. In a recent letter to Nature, Breen et al. (2012) argued that epistasis must be "pervasive throughout protein evolution" because the observed ratio between the per-site rates of non-synonymous and synonymous substitutions (dN/dS) is much lower than would be expected in the absence of epistasis. However, when calculating the expected dN/dS ratio in the absence of epistasis, Breen et al. assumed that all amino acids observed in a protein alignment at any particular position have equal fitness. Here, we relax this unrealistic assumption and show that any dN/dS value can in principle be achieved at a site, without epistasis. Furthermore, for all nuclear and chloroplast genes in the Breen et al. dataset, we show that the observed dN/dS values and the observed patterns of amino acid diversity at each site are jointly consistent with a non-epistatic model of protein evolution.Comment: This manuscript is in response to "Epistasis as the primary factor in molecular evolution" by Breen et al. Nature 490, 535-538 (2012

Published and not fully published double-blind, randomised, controlled trials with oral naratriptan in the treatment of migraine: a review based on the GSK Trial Register

Naratriptan 2.5 mg is now an over-the-counter drug in Germany. This should increase the interest in drug. The GSK Trial Register was searched for published and unpublished double-blind, randomised, controlled trials (RCTs) concerning the use of naratriptan in migraine. Only 7 of 17 RCTs are published in full. Naratriptan 2.5 mg is superior to placebo for acute migraine treatment in 6 RCTs, but inferior to sumatriptan 100 mg and rizatriptan 10 mg in one RCT each. This dose of naratriptan has no more adverse events than placebo. Naratriptan 1 mg b.i.d. has some effect in the short-term prophylactic treatment of menstruation-associated migraine in 3 RCTs. In 2 RCTs, naratriptan 2.5 mg was equivalent to naproxen sodium 375 mg for migraine-related quality of life. Naratriptan 2.5 mg (34% preference) was superior to naproxen sodium 500 mg (25% preference). Naratriptan 2.5 mg is better than placebo in the acute treatment of migraine. The adverse effect profile of naratriptan 2.5 mg is similar to that of placebo. The efficacy of naratriptan 2.5 mg versus NSAIDs is not sufficiently investigated. Naratriptan, when available OTC is a reasonable second or third choice on the step care ladder in the acute treatment of migraine

Photo-antagonism of the GABAA receptor

Neurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility and function at inhibitory synapses is derived indirectly from using recombinant receptors, antibody-tagged native receptors and pharmacological treatments. Here we describe the use of a set of research tools that can irreversibly bind to and affect the function of recombinant and neuronal GABAA receptors following ultraviolet photoactivation. These compounds are based on the competitive antagonist gabazine and incorporate a variety of photoactive groups. By using site-directed mutagenesis and ligand-docking studies, they reveal new areas of the GABA binding site at the interface between receptor β and α subunits. These compounds enable the selected inactivation of native GABAA receptor populations providing new insight into the function of inhibitory synapses and extrasynaptic receptors in controlling neuronal excitation

Mixed axial and transverse deep-water systems: The Cretaceous post-rift Lysing Formation, offshore Norway

Deep-water stratigraphic successions from syn- to post-rift stages are an archive of evolving physiographic configurations, and can record axial and transverse sedimentary sources. The healing of topography decreases the influence of syn-rift structures on sedimentation patterns and transport processes over time, which leads to a long-term transition from dominantly axial to transverse dispersal patterns. The Halten and Dønna terraces, offshore mid-Norway, comprise a series of rift-related sub-basins established during the Jurassic, which were infilled with sediments during the Cretaceous. The Cretaceous Lysing Formation developed as slope- and basin-floor fans within a series of weakly confined post-rift sub-basins with some shallow marine deposits interpreted on the basin margins. A deep-water setting is supported by seismic interpretation, and bed type and architectural element analysis in all cored and uncored wells in the area. We document that an axial submarine fan system was active throughout the post-rift stage due to subtle inherited topography from syn-rift structures, which interacted with locally sourced transverse sediment sources. This led to a complicated stratigraphic architecture, with lobe fringe deposits of the axial fan system juxtaposed with channel-fills and channel-lobe transition zone deposits of transverse systems. The refined palaeogeographic reconstruction of the Lysing Formation illustrates how subtle topography can impact sediment routing patterns many millions of years after the end of rifting and can be used for palaeoenvironmental interpretations in other post-rift settings

Influenza pandemic: perception of risk and individual precautions in a general population. Cross sectional study

BACKGROUND: An influenza pandemic may have considerable impact on health and societal functioning. The aim of this study was to explore people's reflections on the consequences of a pandemic. METHODS: Cross-sectional web-based survey of 1,168 Norwegians aged 16–82 years. The main outcome measures were answers to questions about a potential pandemic ("serious influenza epidemic"): statements about personal precautions including stockpiling Tamiflu(®), the perceived number of fatalities, the perceived effects of Tamiflu(®), the sources of information about influenza and trust in public information. RESULTS: While 80% of the respondents stated that they would be "careful about personal hygiene", only a few would stay away from work (2%), or move to an isolated place (4%). While 27% of respondents were uncertain about the number of fatalities during an influenza pandemic, 48% thought it would be lower than the estimate of Norwegian health authorities (0.05%–1%) and only 3% higher. At least half of the respondents thought that Tamiflu(® )might reduce the mortality risk, but less than 1% had personally purchased the drug. The great majority had received their information from the mass media, and only 9% directly from health authorities. Still the majority (65%) trusted information from the authorities, and only 9% reported overt distrust. CONCLUSION: In Norway, considerable proportions of people seem to consider the mortality risk during a pandemic less than health authorities do. Most people seem to be prepared to take some, but not especially disruptive, precautions

Opening a new window to other worlds with spectropolarimetry

A high level of diversity has already been observed among the planets of our own Solar System. As such, one expects extrasolar planets to present a wide range of distinctive features, therefore the characterisation of Earth- and super Earth-like planets is becoming of key importance in scientific research. The SEARCH (Spectropolarimetric Exoplanet AtmospheRe CHaracerisation) mission proposal of this paper represents one possible approach to realising these objectives. The mission goals of SEARCH include the detailed characterisation of a wide variety of exoplanets, ranging from terrestrial planets to gas giants. More specifically, SEARCH will determine atmospheric properties such as cloud coverage, surface pressure and atmospheric composition, and may also be capable of identifying basic surface features. To resolve a planet with a semi major axis of down to 1.4AU and 30pc distant SEARCH will have a mirror system consisting of two segments, with elliptical rim, cut out of a parabolic mirror. This will yield an effective diameter of 9 meters along one axis. A phase mask coronagraph along with an integral spectrograph will be used to overcome the contrast ratio of star to planet light. Such a mission would provide invaluable data on the diversity present in extrasolar planetary systems and much more could be learned from the similarities and differences compared to our own Solar System. This would allow our theories of planetary formation, atmospheric accretion and evolution to be tested, and our understanding of regions such as the outer limit of the Habitable Zone to be further improved.Comment: 23 pages, accepted for publication in Experimental Astronom