Adams JC

Agathocleous M

Aihara K

Amy S. Findlay

Austin CP

Cayouette M

Cepko CL

Chizu Nakamoto

de Iongh R

Ehrlich D

Elaine Durward

Ewa D. Zakrzewska

Fekete DM

Flanagan JG

Frade JM

Galvez JM

Hansen MJ

Harada H

Harpavat S

Hashimoto T

Holt CE

Hu WY

Isenmann S

Jablonski MM

Jiang Y

Katahira T

Koga A

Kuroda S

Layer PG

Marianne Bronner

Martinez-Morales JR

Masai I

Masaru Nakamoto

Matsuhashi S

Matsuoka H

Matsuyama S

McCabe KL

McLaughlin T

Moore SW

Munemasa Y

Nakamura R

Nelson BR

Oyasu M

Patel A

Prada C

Price J

Rachel RA

Raymond SM

Sato Y

Snow RL

Soh-Leh Kuan

Stiemke MM

Strauss O

Takuma Endo

Wang JT

Watanabe TK

Wetts R

Xiang M

Yee JK

Zhang XM

Zhufeng Ouyang

Molecular Biology of the Cell

English

PubMed

Nakamoto, Chizu

Kuan, Soh Leh

Findlay, Amy S.

Durward, Elaine

Ouyang, Zhufeng

Zakrzewska, Ewa

Endo, Takuma

Nakamoto, Masaru

Aberdeen University Research

A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases.

Bifunctional action of ephrin-B1 as a repellent and attractant to control bidirectional branch extension in dorsal-ventral retinotopic mapping.

Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2.

Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration.

Cell fate determination in the vertebrate retina.

Cellerino A

Cellular determination in the Xenopus retina is independent of lineage and birth date.

Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats.

Differentiation of the vertebrate retina is coordinated by an FGF signaling center.

Disease gene candidates revealed by expression profiling of retinal ganglion cell development.

Distribution of acidic and basic fibroblast growth factors (FGF) in the foetal rat eye: implications for lens development.

Enhanced long-term potentiation in vivo in dentate gyrus of NELL2-deficient mice.

From progenitors to differentiated cells in the vertebrate retina.

Gene expression from transcriptionally disabled retroviral vectors.

Gene silencing in chick embryos with a vector-based small interfering RNA system.

Iannaccone A

Immunocytochemical localization of a neuron-specific thrombospondin1-like protein, NELL2: light and electron microscopic studies in the rat brain.

In vitro guidance of retinal axons by a tectal lamina-specific glycoprotein Nel.

Inhibition of retroviral pathogenesis by RNA interference.

Inverted (displaced) retinal amacrine cells and their embryonic development in the chick.

Kainic acid destroys displaced amacrine cells in post-hatch chicken retina.

Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer.

Lineage in the vertebrate retina.

Lucifer yellow stains displaced amacrine cells of the chicken retina during embryonic development.

Migration and differentiation of neurons in the retina and optic tectum of the chick.

Multipotent precursors can give rise to all major cell types of the frog retina.

NELL2 promotes motor and sensory neuron differentiation and stimulates mitogenesis in DRG in vivo.

Netrins and their receptors. Adv Exp Med Biol 621, 17–31.244 |

Neural map specification by gradients.

New gene, nel, encoding a M(r) 93 K protein with EGF-like repeats is strongly expressed in neural tissues of early stage chick embryos.

New gene, nel, encoding a Mr 91 K protein with EGF-like repeats is strongly expressed in neural tissues of early stage chick embryos.

Overexpression of FGF-2 alters cell fate specification in the developing retina of Xenopus laevis.

Pea3 expression is regulated by FGF signaling in developing retina.

Photoreceptor outer segment development in Xenopus laevis: influence of the pigment epithelium.

Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo.

Restricted neural epidermal growth factor-like like 2 (NELL2) expression during muscle and neuronal differentiation.

Retinal axon response to ephrinas shows a graded, concentration-dependent transition from growth promotion to inhibition.

Rodriguez-Tebar A

Spatial and temporal patterns of neurogenesis in the chick retina.

Spatial learning of mice lacking a neuron-specific epidermal growth factor family protein,

Spatiotemporal features of early neuronogenesis differ in wildtype and albino mouse retina.

Stable integration and conditional expression of electroporated transgenes in chicken embryos.

Structure-function analysis of Nel, a thrombospondin-1-like glycoprotein involved in neural development and functions.

The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.

The development of the pattern of retinal ganglion cells in the chick retina: mechanisms that control differentiation.

The hedgehog-PKA pathway regulates two distinct steps of the differentiation of retinal ganglion cells: the cell-cycle exit of retinoblasts and their neuronal maturation.

The retinal pigment epithelium in visual function.

The retinal pigmented epithelium is required for development and maintenance of the mouse neural retina.

The thrombospondins.

Tracing retinal fiber trajectory with a method of transposon-mediated genomic integration in chick embryo.

Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells.

Transposable element in fish.

VEGF activates divergent intracellular signaling components to regulate retinal progenitor cell proliferation and neuronal differentiation.

Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch.

Yang XJ (2001a). Regulation of retinal ganglion cell production by Sonic hedgehog.

Yang XJ (2001b). Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis.

Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development

For correct functioning of the nervous system, the appropriate number and complement of neuronal cell types must be produced during development. However, the molecular mechanisms that regulate the production of individual classes of neurons are poorly understood. In this study, we investigate the function of the thrombospondin-1–like glycoprotein, Nel (neural epidermal growth factor [EGF]-like), in the generation of retinal ganglion cells (RGCs) in chicks. During eye development, Nel is strongly expressed in the presumptive retinal pigment epithelium and RGCs. Nel overexpression in the developing retina by in ovo electroporation increases the number of RGCs, whereas the number of displaced amacrine cells decreases. Conversely, knockdown of Nel expression by transposon-mediated introduction of RNA interference constructs results in decrease in RGC number and increase in the number of displaced amacrine cells. Modifications of Nel expression levels do not appear to affect proliferation of retinal progenitor cells, but they significantly alter the progression rate of RGC differentiation from the central retina to the periphery. Furthermore, Nel protects RGCs from apoptosis during retinal development. These results indicate that Nel positively regulates RGC production by promoting their differentiation and survival during development.</jats:p

Crossref

For correct functioning of the nervous system, the appropriate number and complement of neuronal cell types must be produced during development. However, the molecular mechanisms that regulate the production of individual classes of neurons are poorly understood. In this study, we investigate the function of the thrombospondin-1–like glycoprotein, Nel (neural epidermal growth factor [EGF]-like), in the generation of retinal ganglion cells (RGCs) in chicks. During eye development, Nel is strongly expressed in the presumptive retinal pigment epithelium and RGCs. Nel overexpression in the developing retina by in ovo electroporation increases the number of RGCs, whereas the number of displaced amacrine cells decreases. Conversely, knockdown of Nel expression by transposon-mediated introduction of RNA interference constructs results in decrease in RGC number and increase in the number of displaced amacrine cells. Modifications of Nel expression levels do not appear to affect proliferation of retinal progenitor cells, but they significantly alter the progression rate of RGC differentiation from the central retina to the periphery. Furthermore, Nel protects RGCs from apoptosis during retinal development. These results indicate that Nel positively regulates RGC production by promoting their differentiation and survival during development

Kuan, Soh-Leh

Findlay, Amy

Zakrewska, Ewa

ValpoScholar

Valparaiso University

http://dx.doi.org/10.1091/mbc.E13-08-0453

Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development

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Aberdeen University Research

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ValpoScholar

Valparaiso University